Middleton's Allergy
1. Cover image - p. i 2. Title Page - p. i 3. Table of Contents - p. i 4. Copyright - p. iv 5. Foreword - p. viii 6. Preface - p. ix 7. List of Contributors - p. x 8. Assessments - p. xx 9. Section A Basic Sciences Underlying Allergy and Immunology - p. xx 10. 1 Innate Immunity - p. 1 11. 2 Adaptive Immunity - p. 20 12. 3 Immunoglobulin Structure and Function - p. 30 13. 4 Immune Tolerance - p. 44 14. 5 Cytokines in Allergic Inflammation - p. 65 15. 6 Cellular Adhesion in Inflammation - p. 81 16. 7 Chemokines - p. 95 17. 8 The Complement System - p. 110 18. 9 Lipid Mediators of Hypersensitivity and Inflammation - p. 132 19. 10 Molecular Biology and Genetic Engineering - p. 154 20. 11 Biology of Lymphocytes - p. 176 21. 12 Innate Lymphoid Cells - p. 191 22. 13 Antigen-Presenting Dendritic Cells - p. 202 23. 14 Biology of Mast Cells and Their Mediators - p. 215 24. 15 Biology of Basophils - p. 243 25. 16 Biology of Eosinophils - p. 255 26. 17 Biology of Neutrophils - p. 267 27. 18 Biology of Monocytes and Macrophages - p. 278 28. 19 Airway Epithelial Cells - p. 287 29. 20 Airway Smooth Muscle in Asthma - p. 301 30. 21 Pathophysiology of Allergic Inflammation - p. 313 31. 22 Genetics and Epigenetics in Allergic Diseases and Asthma - p. 330 32. 23 Systems Biology - p. 352 33. 24 Immunobiology of IgE and IgE Receptors - p. 362 34. 25 Neuronal Control of Airway Function in Allergy - p. 375 35. Section B Aerobiology and Allergens - p. 385.e1 36. 26 The Structure and Function of Allergens - p. 387 37. 27 Aerobiology of Outdoor Allergens - p. 428 38. 28 Indoor Allergens - p. 451 39. 29 Preparation and Standardization of Allergen Extracts* - p. 467 40. 30 Air Pollution - p. 479 41. 31 Effect of the Food Matrix and Processing on the Allergenic Activity of Foods - p. 500 42. Section C The Skin - p. 508.e1 43. 32 Structure of the Skin and Cutaneous Immunology - p. 509 44. 33 Atopic Dermatitis - p. 530 45. 34 Contact Dermatitis - p. 553 46. 35 Urticaria and Angioedema - p. 562 47. 36 Hereditary Angioedema and Bradykinin-Mediated Angioedema - p. 576 48. 37 Immune Complexes and Allergic Disease - p. 591 49. Section D The Eye - p. 604.e1 50. 38 Allergic and Immunologic Diseases of the Eye - p. 605 51. Section E Respiratory Tract - p. 623.e1 52. 39 The Nose and Control of Nasal Airflow - p. 625 53. 40 Allergic and Nonallergic Rhinitis - p. 636 54. 41 Rhinosinusitis and Nasal Polyps - p. 659 55. 42 Development, Structure and Physiology in Normal Lung and in Asthma - p. 673 56. 43 Respiratory Tract Mucosal Immunology - p. 688 57. 44 Airway Mucus and Mucociliary System - p. 702 58. 45 Epidemiology of Asthma and Allergic Diseases - p. 713 59. 46 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma - p. 745 60. 47 Asthma Pathogenesis - p. 768 61. 48 Mouse Models of Allergic Airways Disease - p. 795 62. 49 Diagnosis of Asthma in Infants and Children - p. 816 63. 50 Management of Asthma in Infants and Children - p. 831 64. 51 Diagnosis of Asthma in Adults - p. 848 65. 52 Management of Asthma in Adolescents and Adults - p. 858 66. 53 Emergency Treatment and Approach to the Patient with Acute Asthma - p. 891 67. 54 Approach to the Patient with Exercise-Induced Bronchoconstriction - p. 907 68. 55 Asthma and Allergic Diseases During Pregnancy - p. 919 69. 56 Occupational Allergy and Asthma - p. 940 70. 57 Pathology of Asthma - p. 956 71. 58 Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma - p. 970 72. 59 Immunologic Nonasthmatic Diseases of the Lung - p. 987 73. 60 Approach to the Patient with Chronic Cough - p. 1005 74. 61 Bronchial and Nasal Challenge Testing - p. 1015 75. 62 Lung Imaging - p. 1039 76. 63 Aerosols and Aerosol Drug Delivery Systems - p. 1050 77. Section F Gastrointestinal Tract - p. 1063.e1 78. 64 Gastrointestinal Mucosal Immunology - p. 1065 79. 65 Eosinophilic Gastrointestinal Disorders - p. 1075 80. Section G Systemic Disease - p. 1085.e1 81. 66 Clinical Significance of Immunoglobulin E - p. 1087 82. 67 In Vivo Methods for the Study and Diagnosis of Allergy - p. 1097 83. 68 Approach to the Patient with Recurrent Infections - p. 1111 84. 69 Primary Immunodeficiency Diseases - p. 1123 85. 70 Treatment of Primary Immunodeficiency Diseases - p. 1153 86. 71 HIV Infection and Allergic Disease - p. 1168 87. 72 Laboratory Tests for Allergic and Immunodeficiency Diseases - p. 1181 88. 73 Eosinophilia and Eosinophil-Related Disorders - p. 1197 89. 74 Mastocytosis - p. 1216 90. 75 Anaphylaxis - p. 1228 91. 76 Insect Allergy - p. 1247 92. 77 Drug Allergy - p. 1261 93. 78 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs - p. 1283 94. 79 Reactions to Foods - p. 1294 95. 80 Reactions to Food and Drug Additives - p. 1326 96. 81 Oral Food Challenge Testing - p. 1344 97. 82 Food Allergy Management - p. 1352 98. 83 Adverse Reactions to Vaccines - p. 1371 99. Section H Therapeutics - p. 1390.e1 100. 84 Allergen Control for Prevention and Management of Allergic Diseases - p. 1391 101. 85 Injection Immunotherapy for Inhalant Allergens - p. 1401 102. 86 Sublingual Immunotherapy for Inhalant Allergens - p. 1420 103. 87 Principles of Pharmacotherapeutics - p. 1429 104. 88 Precision Medicine in Allergic Disorders - p. 1441 105. 89 Adherence - p. 1451 106. 90 Anti-Immunoglobulin E Therapy - p. 1460 107. 91 Cytokine-Specific Therapy in Asthma - p. 1472 108. 92 Histamine and Antihistamines - p. 1487 109. 93 Inhaled β2-Agonists - p. 1518 110. 94 Xanthines, Phosphodiesterase Inhibitors, and Chromones - p. 1525 111. 95 Anticholinergic Therapies - p. 1547 112. 96 Glucocorticoids - p. 1561 113. 97 Antileukotriene Therapy in Asthma - p. 1584 114. 98 Unconventional Theories and Unproven Methods in Allergy - p. 1599 115. 99 Complementary and Alternative Medicine - p. 1612 116. Appendix A CD Molecules - p. 1649 117. Index - p. i1
Middleton's Allergy
1. Cover image - p. i 2. Title Page - p. i 3. Table of Contents - p. i 4. Copyright - p. iv 5. Foreword - p. viii 6. Preface - p. ix 7. List of Contributors - p. x 8. Assessments - p. xx 9. Section A Basic Sciences Underlying Allergy and Immunology - p. xx 10. 1 Innate Immunity - p. 1 11. 2 Adaptive Immunity - p. 20 12. 3 Immunoglobulin Structure and Function - p. 30 13. 4 Immune Tolerance - p. 44 14. 5 Cytokines in Allergic Inflammation - p. 65 15. 6 Cellular Adhesion in Inflammation - p. 81 16. 7 Chemokines - p. 95 17. 8 The Complement System - p. 110 18. 9 Lipid Mediators of Hypersensitivity and Inflammation - p. 132 19. 10 Molecular Biology and Genetic Engineering - p. 154 20. 11 Biology of Lymphocytes - p. 176 21. 12 Innate Lymphoid Cells - p. 191 22. 13 Antigen-Presenting Dendritic Cells - p. 202 23. 14 Biology of Mast Cells and Their Mediators - p. 215 24. 15 Biology of Basophils - p. 243 25. 16 Biology of Eosinophils - p. 255 26. 17 Biology of Neutrophils - p. 267 27. 18 Biology of Monocytes and Macrophages - p. 278 28. 19 Airway Epithelial Cells - p. 287 29. 20 Airway Smooth Muscle in Asthma - p. 301 30. 21 Pathophysiology of Allergic Inflammation - p. 313 31. 22 Genetics and Epigenetics in Allergic Diseases and Asthma - p. 330 32. 23 Systems Biology - p. 352 33. 24 Immunobiology of IgE and IgE Receptors - p. 362 34. 25 Neuronal Control of Airway Function in Allergy - p. 375 35. Section B Aerobiology and Allergens - p. 385.e1 36. 26 The Structure and Function of Allergens - p. 387 37. 27 Aerobiology of Outdoor Allergens - p. 428 38. 28 Indoor Allergens - p. 451 39. 29 Preparation and Standardization of Allergen Extracts* - p. 467 40. 30 Air Pollution - p. 479 41. 31 Effect of the Food Matrix and Processing on the Allergenic Activity of Foods - p. 500 42. Section C The Skin - p. 508.e1 43. 32 Structure of the Skin and Cutaneous Immunology - p. 509 44. 33 Atopic Dermatitis - p. 530 45. 34 Contact Dermatitis - p. 553 46. 35 Urticaria and Angioedema - p. 562 47. 36 Hereditary Angioedema and Bradykinin-Mediated Angioedema - p. 576 48. 37 Immune Complexes and Allergic Disease - p. 591 49. Section D The Eye - p. 604.e1 50. 38 Allergic and Immunologic Diseases of the Eye - p. 605 51. Section E Respiratory Tract - p. 623.e1 52. 39 The Nose and Control of Nasal Airflow - p. 625 53. 40 Allergic and Nonallergic Rhinitis - p. 636 54. 41 Rhinosinusitis and Nasal Polyps - p. 659 55. 42 Development, Structure and Physiology in Normal Lung and in Asthma - p. 673 56. 43 Respiratory Tract Mucosal Immunology - p. 688 57. 44 Airway Mucus and Mucociliary System - p. 702 58. 45 Epidemiology of Asthma and Allergic Diseases - p. 713 59. 46 Ontogeny of Immune Development and Its Relationship to Allergic Diseases and Asthma - p. 745 60. 47 Asthma Pathogenesis - p. 768 61. 48 Mouse Models of Allergic Airways Disease - p. 795 62. 49 Diagnosis of Asthma in Infants and Children - p. 816 63. 50 Management of Asthma in Infants and Children - p. 831 64. 51 Diagnosis of Asthma in Adults - p. 848 65. 52 Management of Asthma in Adolescents and Adults - p. 858 66. 53 Emergency Treatment and Approach to the Patient with Acute Asthma - p. 891 67. 54 Approach to the Patient with Exercise-Induced Bronchoconstriction - p. 907 68. 55 Asthma and Allergic Diseases During Pregnancy - p. 919 69. 56 Occupational Allergy and Asthma - p. 940 70. 57 Pathology of Asthma - p. 956 71. 58 Allergic Bronchopulmonary Aspergillosis, Hypersensitivity Pneumonitis, and Epidemic Thunderstorm Asthma - p. 970 72. 59 Immunologic Nonasthmatic Diseases of the Lung - p. 987 73. 60 Approach to the Patient with Chronic Cough - p. 1005 74. 61 Bronchial and Nasal Challenge Testing - p. 1015 75. 62 Lung Imaging - p. 1039 76. 63 Aerosols and Aerosol Drug Delivery Systems - p. 1050 77. Section F Gastrointestinal Tract - p. 1063.e1 78. 64 Gastrointestinal Mucosal Immunology - p. 1065 79. 65 Eosinophilic Gastrointestinal Disorders - p. 1075 80. Section G Systemic Disease - p. 1085.e1 81. 66 Clinical Significance of Immunoglobulin E - p. 1087 82. 67 In Vivo Methods for the Study and Diagnosis of Allergy - p. 1097 83. 68 Approach to the Patient with Recurrent Infections - p. 1111 84. 69 Primary Immunodeficiency Diseases - p. 1123 85. 70 Treatment of Primary Immunodeficiency Diseases - p. 1153 86. 71 HIV Infection and Allergic Disease - p. 1168 87. 72 Laboratory Tests for Allergic and Immunodeficiency Diseases - p. 1181 88. 73 Eosinophilia and Eosinophil-Related Disorders - p. 1197 89. 74 Mastocytosis - p. 1216 90. 75 Anaphylaxis - p. 1228 91. 76 Insect Allergy - p. 1247 92. 77 Drug Allergy - p. 1261 93. 78 Hypersensitivity to Aspirin and Other Nonsteroidal Antiinflammatory Drugs - p. 1283 94. 79 Reactions to Foods - p. 1294 95. 80 Reactions to Food and Drug Additives - p. 1326 96. 81 Oral Food Challenge Testing - p. 1344 97. 82 Food Allergy Management - p. 1352 98. 83 Adverse Reactions to Vaccines - p. 1371 99. Section H Therapeutics - p. 1390.e1 100. 84 Allergen Control for Prevention and Management of Allergic Diseases - p. 1391 101. 85 Injection Immunotherapy for Inhalant Allergens - p. 1401 102. 86 Sublingual Immunotherapy for Inhalant Allergens - p. 1420 103. 87 Principles of Pharmacotherapeutics - p. 1429 104. 88 Precision Medicine in Allergic Disorders - p. 1441 105. 89 Adherence - p. 1451 106. 90 Anti-Immunoglobulin E Therapy - p. 1460 107. 91 Cytokine-Specific Therapy in Asthma - p. 1472 108. 92 Histamine and Antihistamines - p. 1487 109. 93 Inhaled β2-Agonists - p. 1518 110. 94 Xanthines, Phosphodiesterase Inhibitors, and Chromones - p. 1525 111. 95 Anticholinergic Therapies - p. 1547 112. 96 Glucocorticoids - p. 1561 113. 97 Antileukotriene Therapy in Asthma - p. 1584 114. 98 Unconventional Theories and Unproven Methods in Allergy - p. 1599 115. 99 Complementary and Alternative Medicine - p. 1612 116. Appendix A CD Molecules - p. 1649 117. Index - p. i1
