Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics.
1. Chapter 4. Introduction to mitochondrial antiviral signalling protein in different livestock species - p. 93 2. Chapter 5. Mitogenomics and metabolic disease - p. 119 3. Chapter 6. Mitogenomics and viral disease - p. 143 4. Chapter 7. Mitogenomics and bacterial disease - p. 179 5. Chapter 8. Mitogenomics and parasitic disease - p. 239 6. Chapter 9. Mitogenomics and reproduction - p. 279 7. Chapter 10. Mitogenomics and neurodegenerative disorder - p. 333 8. Chapter 11. Mitogenomics and cancer - p. 349 9. Chapter 12. Numtogenesis and its association to disease - p. 377 10. Chapter 13. Mitochondrial replacement therapy: its prospects - p. 393 11. Chapter 14. Mitochondrial transfer and transplantation - p. 401 12. Chapter 15. Whole mitochondrial genome sequencing and its implication in diseases in animal models - p. 419 13. Chapter 16. Implication of gene editing in mitochondrial repair - p. 445 14. Index - p. 493
Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases all 37 mitochondrial genes and their role in immunity. It describes mitochondrial genetics, organization of mitochondrial genes, and their role in immunity against various disease states in animal models. This title also discusses the role of nuclear genes involved in mitochondrial function, as well as numtogenesis and its role in immune function. It provides a holistic introduction to the study of mitochondrial genomics, or mitogenomics. Co-authored by two experts in mitochondrial determinants of health, early chapters describe the structural organization of mitochondria and mitochondrial genetics using different animal models. Central chapters discuss the role of mitogenomics in metabolic, viral, bacterial, and parasitic diseases, fungal infestations, neurodegenerative disorders, and cancer. The book concludes with the prospects of studying mitochondrial genes using next generation sequencing and the various methodologies for correction of genetic defects in mitochondria. Mitochondrial Genomics and Mitochondrial Dysfunction in Diseases offers a strong foundation for academic researchers, industry scientists, and students interested in disease resistance, immunology, and mitogenomics.
1. Chapter 4. Introduction to mitochondrial antiviral signalling protein in different livestock species - p. 93 2. Chapter 5. Mitogenomics and metabolic disease - p. 119 3. Chapter 6. Mitogenomics and viral disease - p. 143 4. Chapter 7. Mitogenomics and bacterial disease - p. 179 5. Chapter 8. Mitogenomics and parasitic disease - p. 239 6. Chapter 9. Mitogenomics and reproduction - p. 279 7. Chapter 10. Mitogenomics and neurodegenerative disorder - p. 333 8. Chapter 11. Mitogenomics and cancer - p. 349 9. Chapter 12. Numtogenesis and its association to disease - p. 377 10. Chapter 13. Mitochondrial replacement therapy: its prospects - p. 393 11. Chapter 14. Mitochondrial transfer and transplantation - p. 401 12. Chapter 15. Whole mitochondrial genome sequencing and its implication in diseases in animal models - p. 419 13. Chapter 16. Implication of gene editing in mitochondrial repair - p. 445 14. Index - p. 493
