Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included.
This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.
1. Mitochondrial Intoxication - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Dedication - p. Page vi 7. Contributors - p. Page vi 8. Preface - p. Page xii 9. Acknowledgments - p. Page xvi 10. List of Illustrations - p. Page xvii 11. List of Tables - p. Page xviii 12. 1 : Mitochondrial physiology: An overview - p. Page xviii 13. 2 : Molecular markers of mitochondrial intoxication - p. Page 18 14. 3 : Drug-induced mitochondrial impairment: Mechanisms and testing systems - p. Page 41 15. 4 : Clinical consequences of drug-induced mitochondrial dysfunction - p. Page 68 16. 5 : Challenges in mitochondrial profiling during pre-clinical studies - p. Page 94 17. 6 : Mitochondrial dysfunction and underlying molecular mechanisms in acrylamide-induced toxicity - p. Page 123 18. 7 : The effects of air pollution toxicants on the mitochondria - p. Page 141 19. 8 : Mitochondrial toxicity of aflatoxin B1 - p. Page 159 20. 9 : The effects of alcohol abuse against the mitochondria: Functional consequences for liver, muscle, and the brain - p. Page 175 21. 10 : The effect of aluminum on mitochondrial dysfunctions - p. Page 192 22. 11 : Discovery of amiodarone mitochondrial toxicity in liver and beyond - p. Page 228 23. 12 : Ammonia - p. Page 245 24. 13 : Mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines - p. Page 264 25. 14 : Mitochondrial intoxication by anthracyclines - p. Page 289 26. 15 : Antidepressants, mood-stabilizing drugs, and mitochondrial functions: For better or for worse - p. Page 315 27. 16 : The effects of HIV and the antiretrovirals on the mitochondria - p. Page 342 28. 17 : The effect of arsenical compounds on mitochondrial metabolism - p. Page 372 29. 18 : Mechanisms of bisphenol A toxicity in mitochondria - p. Page 400 30. 19 : Chemotherapeutic drugs - p. Page 420 31. 20 : Effects of cuprizone on mitochondria - p. Page 432 32. 21 : Effects of Δ9-tetrahydrocannabinol on mitochondria - p. Page 446 33. 22 : Effects of food additives on the mitochondria integrity and functioning - p. Page 466 34. 23 : Mitochondria as a toxicological target for fungicides - p. Page 488 35. 24 : The effects of methylglyoxal on the mitochondria - p. Page 514 36. 25 : The effect of mercury on the mitochondria - p. Page 540 37. 26 : Organohalides - p. Page 551 38. 27 : The effects of organophosphate pesticides on mitochondria - p. Page 579 39. 28 : Mitochondrial oxygen toxicity - p. Page 595 40. 29 : Polychlorinated biphenyls - p. Page 607 41. 30 : The effects of polycyclic aromatic hydrocarbons on mitochondria - p. Page 651 42. 31 : The effects of pyrethroids on the mitochondria - p. Page 678 43. 32 : The effects of sodium nitrate on mitochondria - p. Page 700 44. 33 : Mitochondrial zinc toxicity - p. Page 718 45. Index - p. Page 736
Mitochondrial Intoxication explores the effects toxic molecules can have upon mitochondrial physiology in the human body. Each chapter is dedicated to a specific toxicant, including pollutants, food additives, illicit and pharmaceutical drugs, and heavy metals. This book considers the implications and impact these have upon mitochondria and the diseases that can result from dysfunction and impairment in the human body. Furthermore, the book provides an overview of mitochondrial physiology and assesses the advances and challenges in testing mitochondrial toxicity. Case studies exploring mitochondrial intoxication in pregnancy and in the geriatric population are also included.
This is a comprehensive reference on the main toxicants impacting mitochondria in the human body, and the consequences this can have for health and disease.
1. Mitochondrial Intoxication - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page i 4. Table of Contents - p. Page iv 5. Copyright - p. Page v 6. Dedication - p. Page vi 7. Contributors - p. Page vi 8. Preface - p. Page xii 9. Acknowledgments - p. Page xvi 10. List of Illustrations - p. Page xvii 11. List of Tables - p. Page xviii 12. 1 : Mitochondrial physiology: An overview - p. Page xviii 13. 2 : Molecular markers of mitochondrial intoxication - p. Page 18 14. 3 : Drug-induced mitochondrial impairment: Mechanisms and testing systems - p. Page 41 15. 4 : Clinical consequences of drug-induced mitochondrial dysfunction - p. Page 68 16. 5 : Challenges in mitochondrial profiling during pre-clinical studies - p. Page 94 17. 6 : Mitochondrial dysfunction and underlying molecular mechanisms in acrylamide-induced toxicity - p. Page 123 18. 7 : The effects of air pollution toxicants on the mitochondria - p. Page 141 19. 8 : Mitochondrial toxicity of aflatoxin B1 - p. Page 159 20. 9 : The effects of alcohol abuse against the mitochondria: Functional consequences for liver, muscle, and the brain - p. Page 175 21. 10 : The effect of aluminum on mitochondrial dysfunctions - p. Page 192 22. 11 : Discovery of amiodarone mitochondrial toxicity in liver and beyond - p. Page 228 23. 12 : Ammonia - p. Page 245 24. 13 : Mitochondrial disruption as a contributing factor for the neurotoxicity of amphetamines - p. Page 264 25. 14 : Mitochondrial intoxication by anthracyclines - p. Page 289 26. 15 : Antidepressants, mood-stabilizing drugs, and mitochondrial functions: For better or for worse - p. Page 315 27. 16 : The effects of HIV and the antiretrovirals on the mitochondria - p. Page 342 28. 17 : The effect of arsenical compounds on mitochondrial metabolism - p. Page 372 29. 18 : Mechanisms of bisphenol A toxicity in mitochondria - p. Page 400 30. 19 : Chemotherapeutic drugs - p. Page 420 31. 20 : Effects of cuprizone on mitochondria - p. Page 432 32. 21 : Effects of Δ9-tetrahydrocannabinol on mitochondria - p. Page 446 33. 22 : Effects of food additives on the mitochondria integrity and functioning - p. Page 466 34. 23 : Mitochondria as a toxicological target for fungicides - p. Page 488 35. 24 : The effects of methylglyoxal on the mitochondria - p. Page 514 36. 25 : The effect of mercury on the mitochondria - p. Page 540 37. 26 : Organohalides - p. Page 551 38. 27 : The effects of organophosphate pesticides on mitochondria - p. Page 579 39. 28 : Mitochondrial oxygen toxicity - p. Page 595 40. 29 : Polychlorinated biphenyls - p. Page 607 41. 30 : The effects of polycyclic aromatic hydrocarbons on mitochondria - p. Page 651 42. 31 : The effects of pyrethroids on the mitochondria - p. Page 678 43. 32 : The effects of sodium nitrate on mitochondria - p. Page 700 44. 33 : Mitochondrial zinc toxicity - p. Page 718 45. Index - p. Page 736
