Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention.
This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.
1. Mitophagy in Health and Disease - p. iii 2. Title Page - p. iii 3. Copyright Page - p. iv 4. Table of Contents - p. iv 5. List of contributors - p. xi 6. About the editor - p. xv 7. Preface - p. xvii 8. Chapter 1 PINK1-Parkin quality control mitophagy pathway in Parkinson’s disease - p. 1 9. Chapter 2 Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions - p. 25 10. Chapter 3 Role of AMPK/ULK1 signaling in mitophagy - p. 43 11. Chapter 4 Mitochondrial proteases - p. 71 12. Chapter 5 The mitochondrial unfolded protein response in health and disease - p. 83 13. Chapter 6 Mitochondria-derived vesicles: from quality control to inflammation and extracellular vesicles - p. 103 14. Chapter 7 Molecular regulation of mitochondrial turnover by exercise: tissue adaptation through mitochondrial biogenesis and mitophagy - p. 119 15. Chapter 8 Role of mitophagy and mitochondria in aging and cellular senescence - p. 143 16. Chapter 9 Mitophagy in erythropoiesis - p. 169 17. Chapter 10 The dual role of mitophagy in cancer and its targeting for effective anticancer therapy - p. 187 18. Chapter 11 Mitophagy and neurodegenerative disease - p. 207 19. Chapter 12 The antiaging role of mitophagy - p. 227 20. Chapter 13 Compromised mitophagy in aging and neurodegenerative diseases - p. 243 21. Chapter 14 Mitophagy inducers as potential therapeutic agents - p. 263 22. Chapter 15 Mitochondrial quality control and the microphthalmia/transcription factor E (MiTF/TFE) family - p. 277 23. Chapter 16 Cardioprotection through mitophagy - p. 291 24. Chapter 17 Fasting, mitophagy, and aging - p. 309 25. Chapter 18 Aldehydes, mitophagy, and the pathogenesis of alcohol-associated and metabolic dysfunction-associated steatohepatitis - p. 329 26. Chapter 19 Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis - p. 363 27. Chapter 20 The Sodom and Gomorrah conundrum of yeast mitophagy - p. 381 28. Chapter 21 Sphingolipid metabolism in the regulation of mitophagy: implications in cancer therapy, immune cell function, and neurodegeneration - p. 399 29. Chapter 22 Formation of mitophagosomes - p. 427 30. Chapter 23 Mitophagy in hepatic ischemia/reperfusion - p. 455 31. Index - p. 481
Mitophagy in Health and Disease: Mechanisms, Health Implications, and Therapeutic Opportunities is a complete reference to this key cellular process involved in homeostasis. The book addresses the machinery and mechanisms of mitophagy, including an overview of mito-biogenesis and dynamics and specific types of mitophagy. Other sections cover mitophagy across the human lifespan, from development to aging, discussing the interplay between inflammation and several conditions. The final part covers therapeutic opportunities presented by targeting mitophagy, including inducers and inhibitors, targeting strategies, and studies specific to cardioprotection and neurodegenerative diseases prevention.
This is the ideal reference for cellular and molecular biologists needing a consistent and thorough overview of the subject, as well as research physicians in areas where mitochondria play a key role.
1. Mitophagy in Health and Disease - p. iii 2. Title Page - p. iii 3. Copyright Page - p. iv 4. Table of Contents - p. iv 5. List of contributors - p. xi 6. About the editor - p. xv 7. Preface - p. xvii 8. Chapter 1 PINK1-Parkin quality control mitophagy pathway in Parkinson’s disease - p. 1 9. Chapter 2 Ubiquitin-independent mitophagy: mechanisms and pathophysiological functions - p. 25 10. Chapter 3 Role of AMPK/ULK1 signaling in mitophagy - p. 43 11. Chapter 4 Mitochondrial proteases - p. 71 12. Chapter 5 The mitochondrial unfolded protein response in health and disease - p. 83 13. Chapter 6 Mitochondria-derived vesicles: from quality control to inflammation and extracellular vesicles - p. 103 14. Chapter 7 Molecular regulation of mitochondrial turnover by exercise: tissue adaptation through mitochondrial biogenesis and mitophagy - p. 119 15. Chapter 8 Role of mitophagy and mitochondria in aging and cellular senescence - p. 143 16. Chapter 9 Mitophagy in erythropoiesis - p. 169 17. Chapter 10 The dual role of mitophagy in cancer and its targeting for effective anticancer therapy - p. 187 18. Chapter 11 Mitophagy and neurodegenerative disease - p. 207 19. Chapter 12 The antiaging role of mitophagy - p. 227 20. Chapter 13 Compromised mitophagy in aging and neurodegenerative diseases - p. 243 21. Chapter 14 Mitophagy inducers as potential therapeutic agents - p. 263 22. Chapter 15 Mitochondrial quality control and the microphthalmia/transcription factor E (MiTF/TFE) family - p. 277 23. Chapter 16 Cardioprotection through mitophagy - p. 291 24. Chapter 17 Fasting, mitophagy, and aging - p. 309 25. Chapter 18 Aldehydes, mitophagy, and the pathogenesis of alcohol-associated and metabolic dysfunction-associated steatohepatitis - p. 329 26. Chapter 19 Mitochondrial dynamics and quality control in alcohol-associated liver disease and liver tumorigenesis - p. 363 27. Chapter 20 The Sodom and Gomorrah conundrum of yeast mitophagy - p. 381 28. Chapter 21 Sphingolipid metabolism in the regulation of mitophagy: implications in cancer therapy, immune cell function, and neurodegeneration - p. 399 29. Chapter 22 Formation of mitophagosomes - p. 427 30. Chapter 23 Mitophagy in hepatic ischemia/reperfusion - p. 455 31. Index - p. 481
