Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Dedication - p. page_v 6. Preface - p. page_xi 7. Chapter 1: Molecular evolution: The origins of interaction - p. page_xii 8. Chapter 2: Thermodynamics of secondary metabolism: The triumph of living systems - p. page_20 9. Chapter 3: Natural products and molecular networks - p. page_38 10. Chapter 4: Chemical evolution: Life as the lab of the universe - p. page_56 11. Chapter 5: Autopoietic symbiogenesis in secondary metabolism - p. page_73 12. Chapter 6: Metabolomics of epigenetics: A history of the integrome - p. page_90 13. Chapter 7: Systems biology, drug development, and clinical outcomes - p. page_107 14. Chapter 8: Toxical autopoiesis - p. page_123 15. Chapter 9: Autocatakinesis systems in drug discovery - p. page_141 16. Chapter 10: Biophysics applications in drug discovery: Working toward a new integrative model - p. page_158 17. Index - p. page_175
Molecular Evolutionary Models in Drug Discovery explores the application of evolutionary molecular models in drug discovery in which secondary metabolites play a fundamental role. Secondary metabolites are not produced in isolation, they are the result of the interaction of genes, metabolism and the environment. The book examines the role of secondary metabolites as leads in drug discovery and on the development of a rational bioprospecting model for new medicines based on the evolution of secondary metabolism. These evolutionary models are part of biological systems and are the most reliable expression of the functioning of living beings.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Dedication - p. page_v 6. Preface - p. page_xi 7. Chapter 1: Molecular evolution: The origins of interaction - p. page_xii 8. Chapter 2: Thermodynamics of secondary metabolism: The triumph of living systems - p. page_20 9. Chapter 3: Natural products and molecular networks - p. page_38 10. Chapter 4: Chemical evolution: Life as the lab of the universe - p. page_56 11. Chapter 5: Autopoietic symbiogenesis in secondary metabolism - p. page_73 12. Chapter 6: Metabolomics of epigenetics: A history of the integrome - p. page_90 13. Chapter 7: Systems biology, drug development, and clinical outcomes - p. page_107 14. Chapter 8: Toxical autopoiesis - p. page_123 15. Chapter 9: Autocatakinesis systems in drug discovery - p. page_141 16. Chapter 10: Biophysics applications in drug discovery: Working toward a new integrative model - p. page_158 17. Index - p. page_175
