Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.
Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.
1. Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page v 7. Preface - p. Page vi 8. List of Illustrations - p. Page vii 9. List of Tables - p. Page viii 10. Chapter 1 : Fundamentals and mechanisms - p. Page viii 11. Chapter 2 : Stimuli-responsive biomaterials for regulation of dynamic cellular responses toward advanced tissue engineering - p. Page 18 12. Chapter 3 : Closer to nature: Recreating extracellular matrix microenvironment with 3D printing - p. Page 38 13. Chapter 4 : Surface modification and its influence on osseointegration of implants - p. Page 81 14. Chapter 5 : Mechanical performance of metallic biomaterials: Fundamentals and mechanisms - p. Page 105 15. Chapter 6 : Mechanobiology regulation - p. Page 124 16. Chapter 7 : Electrical/magnetic stimulation in musculoskeletal tissue engineering and regenerative medicine - p. Page 141 17. Chapter 8 : Cell–biomaterials interactions: Mechanical forces assessment by traction force microscopy - p. Page 176 18. Chapter 9 : Mineralogical characterization of calcium phosphate cements for clinical needs - p. Page 195 19. Chapter 10 : Design of polymeric biomaterials at multiscale - p. Page 214 20. Chapter 11 : Immunomodulatory hydrogels: Design and applications - p. Page 234 21. Chapter 12 : Scaffolding design and structure/function: Focus on electrospinning for tendon engineering - p. Page 258 22. Chapter 13 : Scaffolding design and structure/function: Advanced manufacturing - p. Page 281 23. Chapter 14 : Bioprinting strategy toward realization of structural and functional tissue engineering scaffolds - p. Page 298 24. Chapter 15 : Dynamic models for investigating structure/function of biomaterials: bioreactors - p. Page 327 25. Chapter 16 : Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling - p. Page 365 26. Chapter 17 : In vivo animal models - p. Page 396 27. Chapter 18 : Regulatory and clinical translation - p. Page 426 28. Chapter 19 : Cells–biomaterials structure–function at different length scales - p. Page 459 29. Index - p. Page 500
Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine addresses the key concepts involved in the interactions between cells and biomaterials in the musculoskeletal tissue engineering and regenerative medicine field. The updated developments and challenges of the mechanisms/mechanobiology and structure-function properties of those interactions, as well as emerging technologies underlying tissue-engineered scaffolding, are carefully discussed. Lastly, cell engineering and cell-based therapies, growth factors/drugs properties, vascularization, immunomodulation are also outlined.
Given the large number of musculoskeletal disorders and related injuries that can affect muscles, bones and joints and lead to severe complications of the neuromuscular system, it is imperative to develop new treatment strategies to delay or repair associated diseases and to promote optimal long-term health.
1. Multiscale Cell-Biomaterials Interplay in Musculoskeletal Tissue Engineering and Regenerative Medicine - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Contributors - p. Page v 7. Preface - p. Page vi 8. List of Illustrations - p. Page vii 9. List of Tables - p. Page viii 10. Chapter 1 : Fundamentals and mechanisms - p. Page viii 11. Chapter 2 : Stimuli-responsive biomaterials for regulation of dynamic cellular responses toward advanced tissue engineering - p. Page 18 12. Chapter 3 : Closer to nature: Recreating extracellular matrix microenvironment with 3D printing - p. Page 38 13. Chapter 4 : Surface modification and its influence on osseointegration of implants - p. Page 81 14. Chapter 5 : Mechanical performance of metallic biomaterials: Fundamentals and mechanisms - p. Page 105 15. Chapter 6 : Mechanobiology regulation - p. Page 124 16. Chapter 7 : Electrical/magnetic stimulation in musculoskeletal tissue engineering and regenerative medicine - p. Page 141 17. Chapter 8 : Cell–biomaterials interactions: Mechanical forces assessment by traction force microscopy - p. Page 176 18. Chapter 9 : Mineralogical characterization of calcium phosphate cements for clinical needs - p. Page 195 19. Chapter 10 : Design of polymeric biomaterials at multiscale - p. Page 214 20. Chapter 11 : Immunomodulatory hydrogels: Design and applications - p. Page 234 21. Chapter 12 : Scaffolding design and structure/function: Focus on electrospinning for tendon engineering - p. Page 258 22. Chapter 13 : Scaffolding design and structure/function: Advanced manufacturing - p. Page 281 23. Chapter 14 : Bioprinting strategy toward realization of structural and functional tissue engineering scaffolds - p. Page 298 24. Chapter 15 : Dynamic models for investigating structure/function of biomaterials: bioreactors - p. Page 327 25. Chapter 16 : Role of silk fibroin biomaterials as artificial ECM for 3D in vitro modeling - p. Page 365 26. Chapter 17 : In vivo animal models - p. Page 396 27. Chapter 18 : Regulatory and clinical translation - p. Page 426 28. Chapter 19 : Cells–biomaterials structure–function at different length scales - p. Page 459 29. Index - p. Page 500
