Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation.
By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xi 6. Foreword - p. xv 7. Preface - p. xvii 8. Acknowledgments - p. xix 9. Chapter One. Mutagenesis, Genetic Disorders and Diseases - p. 1 10. Chapter Two. Detection of Mutation in Prokaryotic Cells - p. 35 11. Chapter Three. Detection of Gene Mutation in Cultured Mammalian Cells - p. 49 12. Chapter Four. Chromosomal Aberrations - p. 69 13. Chapter Five. In Vivo Cytogenetic Assays - p. 93 14. Chapter Six. Mutagenicity and Genotoxicity Testing in Environmental Pollution Control - p. 113 15. Chapter Seven. Mutagens in Food - p. 133 16. Chapter Eight. Emerging Computational Methods for Predicting Chemically Induced Mutagenicity - p. 161 17. Chapter Nine. Overview of Nonclinical Aspects for Investigational New Drugs Submission: Regulatory Perspectives - p. 177 18. Chapter Ten. Mutagenicity Testing: Regulatory Guidelines and Current Needs - p. 191 19. Chapter Eleven. Detecting Mutations In Vivo - p. 229 20. Chapter Twelve. An In Vitro Male Germ Cell Assay and Its Application for Detecting Phase Specificity of Genotoxins/Mutagens - p. 251 21. Chapter Thirteen. Fluorescence In Situ Hybridization in Genotoxicity Testing - p. 265 22. Chapter Fourteen. DNA Damage, Repair, and Maintenance of Telomere Length: Role of Nutritional Supplements - p. 287 23. Index - p. 309
Mutagenicity: Assays and Applications presents an extensive examination of the detection, assessment and future of mutagenicity, particularly as it concerns human health and the environment. Chapters focused on specific types of mutagens or testing methods for their detection collectively explore the current state of human and environmental mutagenesis, future perspectives and regulatory needs. The test procedures for measuring mutagenicity, their advantages and limitations are described with practical and procedural detail, along with their presentation and data processing aspects. It is an essential reference covering the breadth and depth of the field of mutagenicity studies and regulation.
By providing both important introductory material and practical assays and applications, this book is useful to graduate students, academic and industry researchers and regulators at various stages of their careers, leading to improved risk assessment and regulation.
1. Cover image - p. i 2. Title page - p. ii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. List of Contributors - p. xi 6. Foreword - p. xv 7. Preface - p. xvii 8. Acknowledgments - p. xix 9. Chapter One. Mutagenesis, Genetic Disorders and Diseases - p. 1 10. Chapter Two. Detection of Mutation in Prokaryotic Cells - p. 35 11. Chapter Three. Detection of Gene Mutation in Cultured Mammalian Cells - p. 49 12. Chapter Four. Chromosomal Aberrations - p. 69 13. Chapter Five. In Vivo Cytogenetic Assays - p. 93 14. Chapter Six. Mutagenicity and Genotoxicity Testing in Environmental Pollution Control - p. 113 15. Chapter Seven. Mutagens in Food - p. 133 16. Chapter Eight. Emerging Computational Methods for Predicting Chemically Induced Mutagenicity - p. 161 17. Chapter Nine. Overview of Nonclinical Aspects for Investigational New Drugs Submission: Regulatory Perspectives - p. 177 18. Chapter Ten. Mutagenicity Testing: Regulatory Guidelines and Current Needs - p. 191 19. Chapter Eleven. Detecting Mutations In Vivo - p. 229 20. Chapter Twelve. An In Vitro Male Germ Cell Assay and Its Application for Detecting Phase Specificity of Genotoxins/Mutagens - p. 251 21. Chapter Thirteen. Fluorescence In Situ Hybridization in Genotoxicity Testing - p. 265 22. Chapter Fourteen. DNA Damage, Repair, and Maintenance of Telomere Length: Role of Nutritional Supplements - p. 287 23. Index - p. 309
