Myasthenia Gravis: Disease, Diagnosis and Management is a comprehensive resource that explores recent advancements in diagnosing and treating Myasthenia Gravis, a rare autoimmune disease affecting the neuromuscular junction. With contributions from global experts, this book addresses the increasing prevalence of Myasthenia Gravis, reflecting the latest in diagnostic techniques and novel therapies such as complement inhibitors and FcRn antagonists. It aims to support healthcare professionals in delivering optimal care through evidence-based insights and patient-centered approaches. The book is divided into several chapters, beginning with an overview of the pathogenesis and immunoregulatory defects in Myasthenia Gravis. Subsequent chapters cover diagnostic methods, non-immunosuppressive treatments, and biological therapies targeting the immune system. Key topics include the role of intravenous immunoglobulin (IVIg) and plasma exchange (PLEX) in severe exacerbations, thymectomy, molecular mechanisms, and the potential of hematopoietic stem cell transplants. The book also delves into precision medicine, AI applications, clinical trial considerations, and novel therapeutics like anti-FcRn antibodies. Management strategies for ocular Myasthenia Gravis, and a holistic view of living with the disease are also discussed. Myasthenia Gravis: Disease, Diagnosis and Management is invaluable for healthcare providers, physicians, immunologists, ophthalmologists, rheumatologists, physical therapists, pharmacists, and translators. It offers a modern guide to understanding and managing Myasthenia Gravis, integrating clinical expertise with the latest research to improve patient outcomes.
1. Chapter 1. Introduction to myasthenia gravis and ocular myasthenia gravis - p. 1 2. Chapter 2. Diagnosis of myasthenia gravis - p. 15 3. Chapter 3. Nonimmunosuppressive treatment of myasthenia gravis - p. 33 4. Chapter 4. Therapeutic mechanisms and clinical impact of monoclonal antibodies in myasthenia gravis treatment - p. 55 5. Chapter 5. Novel immunotherapies for myasthenia gravis - p. 75 6. Chapter 6. Management of myasthenia gravis in severe exacerbation - p. 97 7. Chapter 7. Role of thymectomy in myasthenia gravis - p. 115 8. Chapter 8. Molecular Mechanisms of Myasthenia Gravis - p. 137 9. Chapter 9. Management of myasthenia gravis with hematopoietic stem cell transplant - p. 167 10. Chapter 10. Precision medicine in myasthenia gravis - p. 199 11. Chapter 11. Application of artificial intelligence in management of myasthenia gravis - p. 215 12. Chapter 12. Clinical trials and case studies considerations in myasthenia gravis - p. 231 13. Chapter 13. Antineonatal Fc receptor antibodies-based novel therapeutics - p. 277 14. Chapter 14. Management of ocular myasthenia gravis - p. 309 15. Chapter 15. Living with myasthenia gravis and future perspective - p. 331 16. Index - p. 357
Myasthenia Gravis: Disease, Diagnosis and Management is a comprehensive resource that explores recent advancements in diagnosing and treating Myasthenia Gravis, a rare autoimmune disease affecting the neuromuscular junction. With contributions from global experts, this book addresses the increasing prevalence of Myasthenia Gravis, reflecting the latest in diagnostic techniques and novel therapies such as complement inhibitors and FcRn antagonists. It aims to support healthcare professionals in delivering optimal care through evidence-based insights and patient-centered approaches. The book is divided into several chapters, beginning with an overview of the pathogenesis and immunoregulatory defects in Myasthenia Gravis. Subsequent chapters cover diagnostic methods, non-immunosuppressive treatments, and biological therapies targeting the immune system. Key topics include the role of intravenous immunoglobulin (IVIg) and plasma exchange (PLEX) in severe exacerbations, thymectomy, molecular mechanisms, and the potential of hematopoietic stem cell transplants. The book also delves into precision medicine, AI applications, clinical trial considerations, and novel therapeutics like anti-FcRn antibodies. Management strategies for ocular Myasthenia Gravis, and a holistic view of living with the disease are also discussed. Myasthenia Gravis: Disease, Diagnosis and Management is invaluable for healthcare providers, physicians, immunologists, ophthalmologists, rheumatologists, physical therapists, pharmacists, and translators. It offers a modern guide to understanding and managing Myasthenia Gravis, integrating clinical expertise with the latest research to improve patient outcomes.
1. Chapter 1. Introduction to myasthenia gravis and ocular myasthenia gravis - p. 1 2. Chapter 2. Diagnosis of myasthenia gravis - p. 15 3. Chapter 3. Nonimmunosuppressive treatment of myasthenia gravis - p. 33 4. Chapter 4. Therapeutic mechanisms and clinical impact of monoclonal antibodies in myasthenia gravis treatment - p. 55 5. Chapter 5. Novel immunotherapies for myasthenia gravis - p. 75 6. Chapter 6. Management of myasthenia gravis in severe exacerbation - p. 97 7. Chapter 7. Role of thymectomy in myasthenia gravis - p. 115 8. Chapter 8. Molecular Mechanisms of Myasthenia Gravis - p. 137 9. Chapter 9. Management of myasthenia gravis with hematopoietic stem cell transplant - p. 167 10. Chapter 10. Precision medicine in myasthenia gravis - p. 199 11. Chapter 11. Application of artificial intelligence in management of myasthenia gravis - p. 215 12. Chapter 12. Clinical trials and case studies considerations in myasthenia gravis - p. 231 13. Chapter 13. Antineonatal Fc receptor antibodies-based novel therapeutics - p. 277 14. Chapter 14. Management of ocular myasthenia gravis - p. 309 15. Chapter 15. Living with myasthenia gravis and future perspective - p. 331 16. Index - p. 357
