Nutritional Epigenomics, Second Edition, a volume in the Translational Epigenetics, offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health, and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.
This new edition has been fully updated to reflect current research in the field. All-new and revised chapters consider the social and physical environments associated with DNA methylation, the relationship between nutritional epigenomics and inflammation, chromatin modifications and non-coding RNAs, as well as the epigenetic influence of food bioactives in metabolic disease and cancer, empowering researchers to employ nutritional epigenomics approaches in new, field-driving studies and applications.
1. Section 1. Introduction - p. S1 2. Chapter 1. Introduction to nutritional epigenomics - p. 3 3. Section 2. Epigenetic regulators - p. S2 4. Chapter 2. DNA methylation and chromatin modifications-updates based on chromatin modifiers - p. 13 5. Chapter 3. Small noncoding RNAs as epigenetic regulators—updates based on our understanding of other noncoding RNAs - p. 37 6. Section 3. Epigenomic regulation of disease - p. S3 7. Chapter 4. The impact of race and ethnicity on the social epigenomic regulation of disease - p. 51 8. Chapter 5. The epigenomic impact of methylation in metabolic dysfunction and cancer - p. 67 9. Chapter 6. The role of DNA/RNA methylation on neurocognitive dysfunctions - p. 85 10. Chapter 7. Histone acylation in the epigenomic regulation of insulin action and metabolic disease - p. 101 11. Chapter 8. Cancer and noncoding RNAs - p. 119 12. Section 4. Nutrition, epigenetics, and transgenerational inheritance - p. S4 13. Chapter 9. Race in the social-epigenomic regulation during early development - p. 137 14. Chapter 10. Maternal nutrition, epigenetic programming, and metabolic diseases - p. 155 15. Chapter 11. Epigenetic inheritance of metabolic signals - p. 171 16. Chapter 12. The paternal diet regulates the offspring epigenome and health - p. 193 17. Section 5. Nutritional epigenomics and the circadian clock - p. S5 18. Chapter 13. The interplay between diet, epigenetics, and the circadian clock - p. 205 19. Chapter 14. Epigenetic regulation of the fetal circadian clock: Implications for nutritional programming of circadian and metabolic function - p. 213 20. Chapter 15. The role of the microbiome in the regulation of the circadian clock and metabolism - p. 233 21. Section 6. Caloric restriction and exercise in the epigenomic regulation of aging and disease - p. S6 22. Chapter 16. Epigenomic reprogramming of caloric restriction on aging - p. 253 23. Chapter 17. Dietary restriction in the epigenomic regulation of cardiovascular diseases - p. 271 24. Chapter 18. Epigenomic adaptations of exercise in the control of metabolic disease and cancer - p. 291 25. Section 7. Macro- and micronutrients as epigenomic regulators of health and disease - p. S7 26. Chapter 19. B vitamins and one-carbon metabolism: Impacts on the epigenome during development - p. 321 27. Chapter 20. Food bioactives in the epigenomic regulation of metabolic disease - p. 341 28. Chapter 21. Histone-modifying proteins in the epigenetic effects of dietary polyphenols in cancer - p. 361 29. Chapter 22. Regulation of noncoding RNAs by phytochemicals for cancer therapy - p. 391 30. Chapter 23. Short-chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and disease - p. 401 31. Section 8. Conclusion: Diet, epigenetics, and the microbiome - p. S8 32. Chapter 24. Diet-gut microbiome interactions and the regulation of the epigenome - p. 421 33. Chapter 25. Gut dysbiosis and its epigenomic impact on disease - p. 431 34. Chapter 26. The gut–brain–epigenetic axis in brain health - p. 445 35. Index - p. 473
Nutritional Epigenomics, Second Edition, a volume in the Translational Epigenetics, offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health, and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders. Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.
This new edition has been fully updated to reflect current research in the field. All-new and revised chapters consider the social and physical environments associated with DNA methylation, the relationship between nutritional epigenomics and inflammation, chromatin modifications and non-coding RNAs, as well as the epigenetic influence of food bioactives in metabolic disease and cancer, empowering researchers to employ nutritional epigenomics approaches in new, field-driving studies and applications.
1. Section 1. Introduction - p. S1 2. Chapter 1. Introduction to nutritional epigenomics - p. 3 3. Section 2. Epigenetic regulators - p. S2 4. Chapter 2. DNA methylation and chromatin modifications-updates based on chromatin modifiers - p. 13 5. Chapter 3. Small noncoding RNAs as epigenetic regulators—updates based on our understanding of other noncoding RNAs - p. 37 6. Section 3. Epigenomic regulation of disease - p. S3 7. Chapter 4. The impact of race and ethnicity on the social epigenomic regulation of disease - p. 51 8. Chapter 5. The epigenomic impact of methylation in metabolic dysfunction and cancer - p. 67 9. Chapter 6. The role of DNA/RNA methylation on neurocognitive dysfunctions - p. 85 10. Chapter 7. Histone acylation in the epigenomic regulation of insulin action and metabolic disease - p. 101 11. Chapter 8. Cancer and noncoding RNAs - p. 119 12. Section 4. Nutrition, epigenetics, and transgenerational inheritance - p. S4 13. Chapter 9. Race in the social-epigenomic regulation during early development - p. 137 14. Chapter 10. Maternal nutrition, epigenetic programming, and metabolic diseases - p. 155 15. Chapter 11. Epigenetic inheritance of metabolic signals - p. 171 16. Chapter 12. The paternal diet regulates the offspring epigenome and health - p. 193 17. Section 5. Nutritional epigenomics and the circadian clock - p. S5 18. Chapter 13. The interplay between diet, epigenetics, and the circadian clock - p. 205 19. Chapter 14. Epigenetic regulation of the fetal circadian clock: Implications for nutritional programming of circadian and metabolic function - p. 213 20. Chapter 15. The role of the microbiome in the regulation of the circadian clock and metabolism - p. 233 21. Section 6. Caloric restriction and exercise in the epigenomic regulation of aging and disease - p. S6 22. Chapter 16. Epigenomic reprogramming of caloric restriction on aging - p. 253 23. Chapter 17. Dietary restriction in the epigenomic regulation of cardiovascular diseases - p. 271 24. Chapter 18. Epigenomic adaptations of exercise in the control of metabolic disease and cancer - p. 291 25. Section 7. Macro- and micronutrients as epigenomic regulators of health and disease - p. S7 26. Chapter 19. B vitamins and one-carbon metabolism: Impacts on the epigenome during development - p. 321 27. Chapter 20. Food bioactives in the epigenomic regulation of metabolic disease - p. 341 28. Chapter 21. Histone-modifying proteins in the epigenetic effects of dietary polyphenols in cancer - p. 361 29. Chapter 22. Regulation of noncoding RNAs by phytochemicals for cancer therapy - p. 391 30. Chapter 23. Short-chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and disease - p. 401 31. Section 8. Conclusion: Diet, epigenetics, and the microbiome - p. S8 32. Chapter 24. Diet-gut microbiome interactions and the regulation of the epigenome - p. 421 33. Chapter 25. Gut dysbiosis and its epigenomic impact on disease - p. 431 34. Chapter 26. The gut–brain–epigenetic axis in brain health - p. 445 35. Index - p. 473
