This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include—but are not limited to— Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xv 7. Preface - p. xvii 8. Overview of Myeloproliferative Neoplasms: History, Pathogenesis, Diagnostic Criteria, and Complications - p. 159 9. Epidemiology of the Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms - p. 177 10. The Role of Megakaryocytes in Myelofibrosis - p. 191 11. The Microenvironment in Myeloproliferative Neoplasms - p. 205 12. Genetics of Myeloproliferative Neoplasms - p. 217 13. Epigenetic Dysregulation of Myeloproliferative Neoplasms - p. 237 14. Murine Modeling of Myeloproliferative Neoplasms - p. 253 15. Important Pathologic Considerations for Establishing the Diagnosis of Myelofibrosis - p. 267 16. Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology - p. 279 17. Unmet Need in Essential Thrombocythemia and Polycythemia Vera - p. 295 18. Thrombotic, Vascular, and Bleeding Complications of the Myeloproliferative Neoplasms - p. 305 19. Accelerated and Blast Phase Myeloproliferative Neoplasms - p. 325 20. Traipsing Through Muddy Waters: A Critical Review of the Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes - p. 337 21. Current Clinical Investigations in Myelofibrosis - p. 353 22. Quality of Life in Myeloproliferative Neoplasms: Symptoms and Management Implications - p. 375 23. Application of Stem Cell Therapy in Myelofibrosis - p. 391 24. Immunotherapy and Immunomodulation in Myeloproliferative Neoplasms - p. 409 25. Advancing Effective Clinical Trial Designs for Myelofibrosis - p. 431
This issue of Hematology/Oncology Clinics, guest edited by Drs. Ronald Hoffman, Ross Levine, John Mascarenhas, and Raajit Rampal, is dedicated to Myeloproliferative Neoplasms. This issue is one of six selected each year by the series consulting editors, Drs. George P. Canellos and Edward J. Benz. Topics in this issue include—but are not limited to— Overview of pathophysiology and potential drug targets, The role of the megakaryocyte, Epigenetics, Genetics, Novel technologies for understanding MPN biology, Important pathology considerations, Current Clinical investigations, Quality of life, Application of stem cell therapy, Immunotherapy approaches, Clinical unmet needs in ET/PV, Accelerated and blast phase MPNs, Epidemiology, Thrombotic and hemorrhagic complications, Murine modeling, The microenvironment in MPNs, MDS/MPN overlap syndrome, and Advancing effective clinical trial designs.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. ii 5. Contributors - p. iii 6. Forthcoming Issues - p. xv 7. Preface - p. xvii 8. Overview of Myeloproliferative Neoplasms: History, Pathogenesis, Diagnostic Criteria, and Complications - p. 159 9. Epidemiology of the Philadelphia Chromosome-Negative Classical Myeloproliferative Neoplasms - p. 177 10. The Role of Megakaryocytes in Myelofibrosis - p. 191 11. The Microenvironment in Myeloproliferative Neoplasms - p. 205 12. Genetics of Myeloproliferative Neoplasms - p. 217 13. Epigenetic Dysregulation of Myeloproliferative Neoplasms - p. 237 14. Murine Modeling of Myeloproliferative Neoplasms - p. 253 15. Important Pathologic Considerations for Establishing the Diagnosis of Myelofibrosis - p. 267 16. Application of Single-Cell Approaches to Study Myeloproliferative Neoplasm Biology - p. 279 17. Unmet Need in Essential Thrombocythemia and Polycythemia Vera - p. 295 18. Thrombotic, Vascular, and Bleeding Complications of the Myeloproliferative Neoplasms - p. 305 19. Accelerated and Blast Phase Myeloproliferative Neoplasms - p. 325 20. Traipsing Through Muddy Waters: A Critical Review of the Myelodysplastic Syndrome/Myeloproliferative Neoplasm (MDS/MPN) Overlap Syndromes - p. 337 21. Current Clinical Investigations in Myelofibrosis - p. 353 22. Quality of Life in Myeloproliferative Neoplasms: Symptoms and Management Implications - p. 375 23. Application of Stem Cell Therapy in Myelofibrosis - p. 391 24. Immunotherapy and Immunomodulation in Myeloproliferative Neoplasms - p. 409 25. Advancing Effective Clinical Trial Designs for Myelofibrosis - p. 431
