Nanotherapeutics for Treating Neurodegenerative Disorders is a comprehensive guide to the cutting edge field of nanotherapeutics. This book reviews the complex landscape of neurodegenerative disorders, outlining the nuances of treatment strategies and the imperative role of nanotechnology in revolutionizing therapeutic interventions. From explaining the transport mechanisms of the blood–brain barrier to unveiling the therapeutic potential of stem cell-derived nanocarriers, each chapter offers invaluable insights into the diverse array of nanotherapeutic approaches, helping to reshape the landscape of neurological healthcare. This book provides a comprehensive resource for clinicians, researchers, and students in the fields of neurology and nanotherapeutics.
• Reviews the complexities of treatment strategies and the transformative role of nanotechnology in reshap ing therapeutic interventions
• Offers a diverse array of insights, providing readers with invaluable knowledge across a spectrum of nano therapeutic approaches
• Provides current updates on advanced target-based nanotherapeutics
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Contents - p. v 5. Contributors - p. ix 6. Preface - p. xiii 7. Acknowledgments - p. xv 8. Chapter 1 Concepts, types, and treatment strategies for neurodegenerative disorders - p. 1 9. Chapter 2 Mechanisms of transport across the blood–brain barrier - p. 33 10. Chapter 3 Need for nanotherapeutics to combat neurodegenerative disorders - p. 49 11. Chapter 4 Nanotechnology-mediated drug delivery for addressing protein aggregation - p. 81 12. Chapter 5 Nanocarriers focusing on synuclein misfolding as a therapeutic target - p. 103 13. Chapter 6 Therapeutic potential of stem cells-derived nanocarriers in neurological disorders - p. 127 14. Chapter 7 Emphasizing mitochondrial dysfunction and autophagy in the treatment of neurological disorders - p. 145 15. Chapter 8 Nanocarrier-assisted delivery of drug(s)/genetic material for the targeted treatment of neurodegenerative disease - p. 167 16. Chapter 9 Nanotherapeutics targeting neuroinflammation - p. 185 17. Chapter 10 Nanocarriers mediated DNA repair mechanism against neurological disorders - p. 215 18. Chapter 11 Nanotherapy for targeted inhibition of protein kinase R-like endoplasmic reticulum kinase: Unraveling stress-induced endoplasmic reticulum kinase - p. 239 19. Chapter 12 Nanotechnological and molecular strategies for targeted modulation of microglia in neurodegenerative diseases1 - p. 263 20. Chapter 13 Nanocarriers unveiling ferroptosis as a potential therapeutic target - p. 293 21. Chapter 14 Proteostasis maintenance through nanotechnology: Mitigating protein misfolding, mitochondrial impairment, and oxidative stress - p. 319 22. Chapter 15 Modulation of Hippo signaling pathway dysregulation through nanotechnology for neurodegenerative disorders - p. 365 23. Chapter 16 Nanocarriers modulating fibrinolytic pathways for the treatment of various neurological disorders - p. 387 24. Chapter 17 Targeting glial cells through nanotherapeutic strategies in neurological disorders - p. 415 25. Chapter 18 Oligodendrocytes as an emerging therapeutic targets in neurological disorders - p. 451 26. Index - p. 485
Nanotherapeutics for Treating Neurodegenerative Disorders is a comprehensive guide to the cutting edge field of nanotherapeutics. This book reviews the complex landscape of neurodegenerative disorders, outlining the nuances of treatment strategies and the imperative role of nanotechnology in revolutionizing therapeutic interventions. From explaining the transport mechanisms of the blood–brain barrier to unveiling the therapeutic potential of stem cell-derived nanocarriers, each chapter offers invaluable insights into the diverse array of nanotherapeutic approaches, helping to reshape the landscape of neurological healthcare. This book provides a comprehensive resource for clinicians, researchers, and students in the fields of neurology and nanotherapeutics.
• Reviews the complexities of treatment strategies and the transformative role of nanotechnology in reshap ing therapeutic interventions
• Offers a diverse array of insights, providing readers with invaluable knowledge across a spectrum of nano therapeutic approaches
• Provides current updates on advanced target-based nanotherapeutics
1. Cover image - p. c 2. Title page - p. iii 3. Copyright - p. iv 4. Contents - p. v 5. Contributors - p. ix 6. Preface - p. xiii 7. Acknowledgments - p. xv 8. Chapter 1 Concepts, types, and treatment strategies for neurodegenerative disorders - p. 1 9. Chapter 2 Mechanisms of transport across the blood–brain barrier - p. 33 10. Chapter 3 Need for nanotherapeutics to combat neurodegenerative disorders - p. 49 11. Chapter 4 Nanotechnology-mediated drug delivery for addressing protein aggregation - p. 81 12. Chapter 5 Nanocarriers focusing on synuclein misfolding as a therapeutic target - p. 103 13. Chapter 6 Therapeutic potential of stem cells-derived nanocarriers in neurological disorders - p. 127 14. Chapter 7 Emphasizing mitochondrial dysfunction and autophagy in the treatment of neurological disorders - p. 145 15. Chapter 8 Nanocarrier-assisted delivery of drug(s)/genetic material for the targeted treatment of neurodegenerative disease - p. 167 16. Chapter 9 Nanotherapeutics targeting neuroinflammation - p. 185 17. Chapter 10 Nanocarriers mediated DNA repair mechanism against neurological disorders - p. 215 18. Chapter 11 Nanotherapy for targeted inhibition of protein kinase R-like endoplasmic reticulum kinase: Unraveling stress-induced endoplasmic reticulum kinase - p. 239 19. Chapter 12 Nanotechnological and molecular strategies for targeted modulation of microglia in neurodegenerative diseases1 - p. 263 20. Chapter 13 Nanocarriers unveiling ferroptosis as a potential therapeutic target - p. 293 21. Chapter 14 Proteostasis maintenance through nanotechnology: Mitigating protein misfolding, mitochondrial impairment, and oxidative stress - p. 319 22. Chapter 15 Modulation of Hippo signaling pathway dysregulation through nanotechnology for neurodegenerative disorders - p. 365 23. Chapter 16 Nanocarriers modulating fibrinolytic pathways for the treatment of various neurological disorders - p. 387 24. Chapter 17 Targeting glial cells through nanotherapeutic strategies in neurological disorders - p. 415 25. Chapter 18 Oligodendrocytes as an emerging therapeutic targets in neurological disorders - p. 451 26. Index - p. 485
