Well organized and highly readable, the National Kidney Foundation Primer on Kidney Diseases has offered clear, comprehensive coverage of adult and pediatric kidney diseases for more than 25 years. The thoroughly revised 8th Edition of this authoritative, practical reference covers every relevant topic in the field, making it an excellent resource for residency, fellowship, clinical practice, and board review. It brings you completely up to date with key topics in this fast-changing field, including ongoing clinical research and changing treatment protocols.
This powerful learning tool and clinical reference is a joint publication of Elsevier and the National Kidney Foundation.
Covers every relevant topic in nephrology—from anatomy, physiology, and pathophysiology to diagnosis and management of kidney disease, to fluid and electrolyte disorders, hypertension, dialysis, and renal transplantation.
Presents complex material in a clear, easy-to-understand manner that is both accessible for residents and fellows and comprehensive enough for practicing nephrologists.
Offers new guidance for management of COVID-19 in the Viral Nephropathies chapter.
Contains two new chapters on Global Kidney Disease, and Conservative Kidney Management (CKM), a palliative care option for treating kidney failure without dialysis.
1. Cover Image - p. i 2. Title Page - p. iii 3. Copyright - p. iv 4. Contributors - p. v 5. Preface - p. xiv 6. Table of Contents - p. xv 7. Part 1 Structure and Function of the Kidney - p. 1 8. Chapter 1 Overview of Kidney Structure and Function - p. 2 9. Chapter 2 Kidney Development - p. 19 10. Chapter 3 Assessment of Kidney Function in Acute and Chronic Settings - p. 26 11. Chapter 4 Urinalysis and Urine Microscopy - p. 33 12. Chapter 5 Hematuria and Proteinuria - p. 43 13. Chapter 6 Imaging of the Kidneys - p. 52 14. Part 2 Acid-Base and Electrolytes - p. 69 15. Chapter 7 Hyponatremia and Hypoosmolar Disorders - p. 70 16. Chapter 8 Hypernatremia and Hyperosmolar Disorders - p. 79 17. Chapter 9 Volume, Edema, and the Clinical Use of Diuretics - p. 88 18. Chapter 10 Disorders of Potassium Metabolism - p. 98 19. Chapter 11 Disorders of Calcium, Phosphorus, and Magnesium Homeostasis - p. 109 20. Chapter 12 Approach to Acid-Base Disorders - p. 123 21. Chapter 13 Metabolic Acidosis - p. 133 22. Chapter 14 Metabolic Alkalosis - p. 147 23. Chapter 15 Respiratory Acidosis and Alkalosis - p. 154 24. Part 3 Glomerular Diseases - p. 163 25. Chapter 16 Glomerular Clinicopathologic Syndromes - p. 164 26. Chapter 17 ANCA-Associated Kidney Disease and Vasculitis - p. 176 27. Chapter 18 Minimal Change Disease - p. 187 28. Chapter 19 Focal Segmental Glomerulosclerosis - p. 193 29. Chapter 20 Membranous Nephropathy - p. 200 30. Chapter 21 Immunoglobulin A Nephropathy and Related Disorders - p. 211 31. Part 4 Kidney in Systemic Diseases - p. 221 32. Chapter 22 Complement-Mediated Glomerulonephritis and Thrombotic Microangiopathy - p. 222 33. Chapter 23 Infection-Related Glomerulonephritis - p. 234 34. Chapter 24 Viral Nephropathies: Human Immunodeficiency Virus, Hepatitis C Virus, Hepatitis B Virus, and SARS-CoV-2 - p. 239 35. Chapter 25 Systemic Lupus Erythematosus and the Kidney - p. 248 36. Chapter 26 Pathogenesis, Pathophysiology, and Treatment of Diabetic Kidney Disease - p. 255 37. Chapter 27 Onconephrology - p. 271 38. Chapter 28 Myeloma, Amyloid, and Other Dysproteinemias - p. 280 39. Chapter 29 Cardiorenal Syndrome - p. 289 40. Chapter 30 Liver Disease, Acute Kidney Dysfunction, and the Hepatorenal Syndrome - p. 295 41. Part 5 Acute Kidney Injury - p. 305 42. Chapter 31 Clinical Approach to the Diagnosis of Acute Kidney Injury - p. 306 43. Chapter 32 Acute Tubular Injury and Acute Tubular Necrosis - p. 317 44. Chapter 33 Acute Interstitial Nephritis - p. 325 45. Part 6 Drugs and the Kidney - p. 331 46. Chapter 34 Kidney Disease Caused by Therapeutic Agents - p. 332 47. Chapter 35 Principles of Drug Therapy in Patients With Decreased Kidney Function - p. 343 48. Part 7 Hereditary Kidney Disease - p. 353 49. Chapter 36 APOL1-Mediated Kidney Disease - p. 354 50. Chapter 37 Genetically Based Kidney Transport Disorders - p. 359 51. Chapter 38 Sickle Cell Nephropathy - p. 368 52. Chapter 39 Polycystic and Other Cystic Kidney Diseases - p. 375 53. Chapter 40 Nephronophthisis and Medullary Cystic Kidney Disease - p. 387 54. Chapter 41 Alport Syndrome and Related Disorders - p. 391 55. Chapter 42 Fabry Disease - p. 396 56. Part 8 Tubulointerstitial Diseases - p. 405 57. Chapter 43 Chronic Tubulointerstitial Disease - p. 406 58. Chapter 44 Obstructive Uropathy - p. 414 59. Chapter 45 Nephrolithiasis - p. 422 60. Part 9 Special Circumstances - p. 431 61. Chapter 46 Kidney Diseases in Infants and Children - p. 432 62. Chapter 47 The Kidney in Pregnancy - p. 440 63. Chapter 48 Management of Kidney Disease in the Elderly - p. 451 64. Chapter 49 Global Kidney Disease - p. 461 65. Part 10 Chronic Kidney Disease - p. 471 66. Chapter 50 Development and Progression of Chronic Kidney Disease - p. 472 67. Chapter 51 Staging and Management of Chronic Kidney Disease - p. 483 68. Chapter 52 Nutrition and Kidney Disease - p. 491 69. Chapter 53 Bone and Mineral Disorders in Chronic Kidney Disease - p. 500 70. Chapter 54 Cardiac Function and Cardiovascular Disease in Chronic Kidney Disease - p. 512 71. Chapter 55 Anemia and Other Hematologic Complications of Chronic Kidney Disease - p. 522 72. Part 11 Treatment of Kidney Failure - p. 533 73. Chapter 56 Hemodialysis and Hemofiltration - p. 534 74. Chapter 57 Peritoneal Dialysis - p. 545 75. Chapter 58 Conservative Kidney Management - p. 560 76. Chapter 59 Selection of Prospective Kidney Transplant Recipients and Donors - p. 568 77. Chapter 60 Posttransplantation Monitoring and Outcomes - p. 580 78. Chapter 61 Immunosuppression in Transplantation - p. 593 79. Chapter 62 Infectious Complications of Kidney Transplantation - p. 605 80. Part 12 Hypertension - p. 611 81. Chapter 63 Pathogenesis of Hypertension - p. 612 82. Chapter 64 Evaluation and Management of Hypertension - p. 618 83. Chapter 65 Secondary Hypertension - p. 633 84. Index - p. 647
Well organized and highly readable, the National Kidney Foundation Primer on Kidney Diseases has offered clear, comprehensive coverage of adult and pediatric kidney diseases for more than 25 years. The thoroughly revised 8th Edition of this authoritative, practical reference covers every relevant topic in the field, making it an excellent resource for residency, fellowship, clinical practice, and board review. It brings you completely up to date with key topics in this fast-changing field, including ongoing clinical research and changing treatment protocols.
This powerful learning tool and clinical reference is a joint publication of Elsevier and the National Kidney Foundation.
Covers every relevant topic in nephrology—from anatomy, physiology, and pathophysiology to diagnosis and management of kidney disease, to fluid and electrolyte disorders, hypertension, dialysis, and renal transplantation.
Presents complex material in a clear, easy-to-understand manner that is both accessible for residents and fellows and comprehensive enough for practicing nephrologists.
Offers new guidance for management of COVID-19 in the Viral Nephropathies chapter.
Contains two new chapters on Global Kidney Disease, and Conservative Kidney Management (CKM), a palliative care option for treating kidney failure without dialysis.
1. Cover Image - p. i 2. Title Page - p. iii 3. Copyright - p. iv 4. Contributors - p. v 5. Preface - p. xiv 6. Table of Contents - p. xv 7. Part 1 Structure and Function of the Kidney - p. 1 8. Chapter 1 Overview of Kidney Structure and Function - p. 2 9. Chapter 2 Kidney Development - p. 19 10. Chapter 3 Assessment of Kidney Function in Acute and Chronic Settings - p. 26 11. Chapter 4 Urinalysis and Urine Microscopy - p. 33 12. Chapter 5 Hematuria and Proteinuria - p. 43 13. Chapter 6 Imaging of the Kidneys - p. 52 14. Part 2 Acid-Base and Electrolytes - p. 69 15. Chapter 7 Hyponatremia and Hypoosmolar Disorders - p. 70 16. Chapter 8 Hypernatremia and Hyperosmolar Disorders - p. 79 17. Chapter 9 Volume, Edema, and the Clinical Use of Diuretics - p. 88 18. Chapter 10 Disorders of Potassium Metabolism - p. 98 19. Chapter 11 Disorders of Calcium, Phosphorus, and Magnesium Homeostasis - p. 109 20. Chapter 12 Approach to Acid-Base Disorders - p. 123 21. Chapter 13 Metabolic Acidosis - p. 133 22. Chapter 14 Metabolic Alkalosis - p. 147 23. Chapter 15 Respiratory Acidosis and Alkalosis - p. 154 24. Part 3 Glomerular Diseases - p. 163 25. Chapter 16 Glomerular Clinicopathologic Syndromes - p. 164 26. Chapter 17 ANCA-Associated Kidney Disease and Vasculitis - p. 176 27. Chapter 18 Minimal Change Disease - p. 187 28. Chapter 19 Focal Segmental Glomerulosclerosis - p. 193 29. Chapter 20 Membranous Nephropathy - p. 200 30. Chapter 21 Immunoglobulin A Nephropathy and Related Disorders - p. 211 31. Part 4 Kidney in Systemic Diseases - p. 221 32. Chapter 22 Complement-Mediated Glomerulonephritis and Thrombotic Microangiopathy - p. 222 33. Chapter 23 Infection-Related Glomerulonephritis - p. 234 34. Chapter 24 Viral Nephropathies: Human Immunodeficiency Virus, Hepatitis C Virus, Hepatitis B Virus, and SARS-CoV-2 - p. 239 35. Chapter 25 Systemic Lupus Erythematosus and the Kidney - p. 248 36. Chapter 26 Pathogenesis, Pathophysiology, and Treatment of Diabetic Kidney Disease - p. 255 37. Chapter 27 Onconephrology - p. 271 38. Chapter 28 Myeloma, Amyloid, and Other Dysproteinemias - p. 280 39. Chapter 29 Cardiorenal Syndrome - p. 289 40. Chapter 30 Liver Disease, Acute Kidney Dysfunction, and the Hepatorenal Syndrome - p. 295 41. Part 5 Acute Kidney Injury - p. 305 42. Chapter 31 Clinical Approach to the Diagnosis of Acute Kidney Injury - p. 306 43. Chapter 32 Acute Tubular Injury and Acute Tubular Necrosis - p. 317 44. Chapter 33 Acute Interstitial Nephritis - p. 325 45. Part 6 Drugs and the Kidney - p. 331 46. Chapter 34 Kidney Disease Caused by Therapeutic Agents - p. 332 47. Chapter 35 Principles of Drug Therapy in Patients With Decreased Kidney Function - p. 343 48. Part 7 Hereditary Kidney Disease - p. 353 49. Chapter 36 APOL1-Mediated Kidney Disease - p. 354 50. Chapter 37 Genetically Based Kidney Transport Disorders - p. 359 51. Chapter 38 Sickle Cell Nephropathy - p. 368 52. Chapter 39 Polycystic and Other Cystic Kidney Diseases - p. 375 53. Chapter 40 Nephronophthisis and Medullary Cystic Kidney Disease - p. 387 54. Chapter 41 Alport Syndrome and Related Disorders - p. 391 55. Chapter 42 Fabry Disease - p. 396 56. Part 8 Tubulointerstitial Diseases - p. 405 57. Chapter 43 Chronic Tubulointerstitial Disease - p. 406 58. Chapter 44 Obstructive Uropathy - p. 414 59. Chapter 45 Nephrolithiasis - p. 422 60. Part 9 Special Circumstances - p. 431 61. Chapter 46 Kidney Diseases in Infants and Children - p. 432 62. Chapter 47 The Kidney in Pregnancy - p. 440 63. Chapter 48 Management of Kidney Disease in the Elderly - p. 451 64. Chapter 49 Global Kidney Disease - p. 461 65. Part 10 Chronic Kidney Disease - p. 471 66. Chapter 50 Development and Progression of Chronic Kidney Disease - p. 472 67. Chapter 51 Staging and Management of Chronic Kidney Disease - p. 483 68. Chapter 52 Nutrition and Kidney Disease - p. 491 69. Chapter 53 Bone and Mineral Disorders in Chronic Kidney Disease - p. 500 70. Chapter 54 Cardiac Function and Cardiovascular Disease in Chronic Kidney Disease - p. 512 71. Chapter 55 Anemia and Other Hematologic Complications of Chronic Kidney Disease - p. 522 72. Part 11 Treatment of Kidney Failure - p. 533 73. Chapter 56 Hemodialysis and Hemofiltration - p. 534 74. Chapter 57 Peritoneal Dialysis - p. 545 75. Chapter 58 Conservative Kidney Management - p. 560 76. Chapter 59 Selection of Prospective Kidney Transplant Recipients and Donors - p. 568 77. Chapter 60 Posttransplantation Monitoring and Outcomes - p. 580 78. Chapter 61 Immunosuppression in Transplantation - p. 593 79. Chapter 62 Infectious Complications of Kidney Transplantation - p. 605 80. Part 12 Hypertension - p. 611 81. Chapter 63 Pathogenesis of Hypertension - p. 612 82. Chapter 64 Evaluation and Management of Hypertension - p. 618 83. Chapter 65 Secondary Hypertension - p. 633 84. Index - p. 647
