Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field.
Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research.
1. Chapter 1: Introduction to the Neural Basis of Addiction - p. xii 2. Chapter 2: Animal Models of Addiction - p. 2 3. Chapter 3: Transcriptional and Epigenetic Regulation of Reward Circuitry in Drug Addiction - p. 22 4. Chapter 4: Neural Circuit Plasticity in Addiction - p. 34 5. Chapter 5: Glutamatergic Neuroplasticity in Addiction - p. 60 6. Chapter 6: Fos-Expressing Neuronal Ensembles in Addiction Research - p. 74 7. Chapter 7: Interoceptive Stimulus Effects of Drugs of Abuse - p. 88 8. Chapter 8: Maladaptive Memory Mechanisms in Addiction and Relapse - p. 101 9. Chapter 9: Neural Morphology and Addiction - p. 122 10. Chapter 10: Mechanisms Regulating Compulsive Drug Behaviors - p. 135 11. Chapter 11: Role of Stress-Associated Signaling in Addiction - p. 155 12. Chapter 12: Negative Reinforcement Mechanisms in Addiction - p. 178 13. Chapter 13: Circadian Rhythms and Addiction - p. 188 14. Chapter 14: Role of Oxytocin in Countering Addiction-Associated Behaviors Exacerbated by Stress - p. 212 15. Chapter 15: The Role of Norepinephrine in Drug Addiction: Past, Present, and Future - p. 219 16. Chapter 16: Glial Dysregulation in Addiction - p. 236 17. Chapter 17: Role of the Extracellular Matrix in Addiction - p. 246 18. Chapter 18: Striatal Cell-Type Specific Plasticity in Addiction - p. 258 19. Chapter 19: Harnessing Circuits for the Treatment of Addictive Disorders - p. 269 20. Chapter 20: Conclusions and Future Directions - p. 285 21. Index - p. 289
Neural Mechanisms of Addiction is the only book available that synthesizes the latest research in the field into a single, accessible resource covering all aspects of how addiction develops and persists in the brain. The book summarizes our most recent understanding on the neural mechanisms underlying addiction. It also examines numerous biobehavioral aspects of addiction disorders, such as reinforcement learning, reward, cognitive dysfunction, stress, and sleep and circadian rhythms that are not covered in any other publication. Readers with find the most up-to-date information on which to build a foundation for their future research in this expanding field.
Combining chapters from leading researchers and thought leaders, this book is an indispensable guide for students and investigators engaged in addiction research.
1. Chapter 1: Introduction to the Neural Basis of Addiction - p. xii 2. Chapter 2: Animal Models of Addiction - p. 2 3. Chapter 3: Transcriptional and Epigenetic Regulation of Reward Circuitry in Drug Addiction - p. 22 4. Chapter 4: Neural Circuit Plasticity in Addiction - p. 34 5. Chapter 5: Glutamatergic Neuroplasticity in Addiction - p. 60 6. Chapter 6: Fos-Expressing Neuronal Ensembles in Addiction Research - p. 74 7. Chapter 7: Interoceptive Stimulus Effects of Drugs of Abuse - p. 88 8. Chapter 8: Maladaptive Memory Mechanisms in Addiction and Relapse - p. 101 9. Chapter 9: Neural Morphology and Addiction - p. 122 10. Chapter 10: Mechanisms Regulating Compulsive Drug Behaviors - p. 135 11. Chapter 11: Role of Stress-Associated Signaling in Addiction - p. 155 12. Chapter 12: Negative Reinforcement Mechanisms in Addiction - p. 178 13. Chapter 13: Circadian Rhythms and Addiction - p. 188 14. Chapter 14: Role of Oxytocin in Countering Addiction-Associated Behaviors Exacerbated by Stress - p. 212 15. Chapter 15: The Role of Norepinephrine in Drug Addiction: Past, Present, and Future - p. 219 16. Chapter 16: Glial Dysregulation in Addiction - p. 236 17. Chapter 17: Role of the Extracellular Matrix in Addiction - p. 246 18. Chapter 18: Striatal Cell-Type Specific Plasticity in Addiction - p. 258 19. Chapter 19: Harnessing Circuits for the Treatment of Addictive Disorders - p. 269 20. Chapter 20: Conclusions and Future Directions - p. 285 21. Index - p. 289
