Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including:
The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China.
Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries.
This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research.
1. Section I. Introduction - p. xv 2. Chapter 1. Advances and Challenges for Neural Regeneration Research - p. 3 3. 1. Nervous System, Nerve Injury, and Neural Regeneration - p. 3 4. 2. Technological Advances in Neural Regeneration Research - p. 3 5. 3. PNS Regeneration - p. 5 6. 4. CNS Regeneration - p. 6 7. 5. Challenges and Opportunities - p. 9 8. Section II. Neural Regeneration in Lower Vertebrates - p. 17 9. Chapter 2. Functional Regeneration and Remyelination in the Zebrafish Optic Nerve - p. 21 10. 1. Introduction to Zebrafish Optic Nerve Injury (ONI) as a Model for Studying Regeneration and Remyelination - p. 21 11. 2. Time Course of Optic Nerve Regeneration in Adult Zebrafish - p. 21 12. 3. Intrinsic and Extrinsic Mechanisms of Axon Regeneration - p. 24 13. 4. Genetic Manipulation Tools Are Very Useful for Studying Regeneration in Zebrafish - p. 27 14. 5. In vivo Imaging of Nerve Regeneration in Zebrafish Larvae - p. 28 15. 6. Imaging Remyelination in Zebrafish - p. 30 16. 7. Behavior Tests Indexed the Visual Functional Recovery after Optic Nerve Injury - p. 32 17. 8. Future Directions - p. 33 18. 9. Conclusions - p. 33 19. Chapter 3. Central Nerve Regeneration in Reptiles - p. 43 20. Chapter 4. Axon Regeneration in the Lamprey Spinal Cord - p. 57 21. Section III. Neural Regeneration in the Peripheral Nervous System - p. 70 22. Chapter 5. Tissue Engineering in Peripheral Nerve Regeneration - p. 73 23. 1. Introduction - p. 73 24. 2. Nerve Scaffolds - p. 73 25. 3. Support Cells - p. 79 26. 4. Growth Factors - p. 82 27. 5. Clinical Applications - p. 86 28. 6. Concluding Remarks - p. 86 29. Chapter 6. Brachial Plexus Avulsion: A Model for Axonal Regeneration Study - p. 101 30. Chapter 7. Conditions Affecting Accuracy of Peripheral Nerve Reinnervation and Functional Recovery - p. 117 31. Chapter 8. Gonadal Steroids in Regeneration and Repair of Neuromuscular Systems - p. 129 32. Section IV. Neural Regeneration in the CNS - p. 150 33. Chapter 9. Myelin-Associated Inhibitors in Axonal Growth after Central Nervous System Injury - p. 153 34. Chapter 10. The Nogo Receptor Pathway in Central Nervous System Axon Regeneration and Therapeutic Opportunities - p. 171 35. Chapter 11. Astrogliosis and Axonal Regeneration - p. 181 36. Chapter 12. The Intrinsic Determinants of Axon Regeneration in the Central Nervous System - p. 197 37. Chapter 13. Optic Nerve Regeneration in Lower Vertebrates and Mammals: Bridging the Gap - p. 209 38. 1. Introduction - p. 209 39. 2. Cell Viability - p. 209 40. 3. Glial-Derived Inhibitors of Axon Growth - p. 211 41. 4. Control of the Regenerative State by Cell-Intrinsic and Cell-Extrinsic Factors - p. 212 42. 5. Intraocular Inflammation and Oncomodulin - p. 215 43. 6. Cell Signaling Pathways for Axon Regeneration of Retinal Ganglion Cells - p. 217 44. 7. Axon Guidance - p. 218 45. 8. Restoration of Central Visual Circuits and Partial Recovery of Visual Responses in Mammals - p. 219 46. 9. Future Prospects - p. 220 47. Chapter 14. Self-Assembling Peptides Mediate Neural Regeneration - p. 229 48. Chapter 15. Wnt Signaling in Spinal Cord Injury - p. 237 49. Chapter 16. Inflammation and Secondary Damage after Spinal Cord Injury - p. 245 50. Chapter 17. Neuroprotection of Retinal Ganglion Cells in Glaucoma by Blocking LINGO-1 Function or Using a Nogo-66 Receptor Antagonist - p. 263 51. Chapter 18. Axonal Regeneration in the Sensory Dorsal Column Pathway - p. 273 52. Section V. Transplantation-Mediated Neural Regeneration - p. 287 53. Chapter 19. Peripheral Nerve Graft-Mediated Axonal Regeneration - p. 291 54. Chapter 20. Transplantation of Olfactory Ensheathing Cells for Neural Repair - p. 301 55. 1. Introduction - p. 301 56. 2. Contribution of OECs to Olfactory Axon Regeneration - p. 301 57. 3. Basic Biology of the Regeneration-Promoting Properties of OECs - p. 302 58. 4. OEC-Mediated Transplantation for Neural Repair in Animal Studies - p. 306 59. 5. OEC-Mediated Transplantation in Clinical Trials - p. 311 60. 6. Concluding Remarks - p. 312 61. Chapter 21. Glial Precursor Cell Transplantation-Mediated Regeneration after Spinal Cord Injury Repair - p. 321 62. Chapter 22. Schwann Cell-Mediated Axonal Regeneration in the Central Nervous System - p. 337 63. Chapter 23. Fetal Spinal Cord Transplantation after Spinal Cord Injury: Around and Back Again - p. 351 64. Section VI. Clinical and Translational Research on Neural Regeneration - p. 365 65. Chapter 24. Spinal Cord Injury: Exercise and Clinical Trials - p. 369 66. Chapter 25. Spinal Cord Regeneration - p. 383 67. 1. Introduction - p. 383 68. 2. Axon Growth Inhibitor Theory - p. 383 69. 3. Glial Scar Theory - p. 384 70. 4. Growth Limitation Theory - p. 385 71. 5. Regenerative Therapies - p. 385 72. 6. Cell Transplants - p. 386 73. 7. Combination Therapies - p. 387 74. 8. Recovery Mechanisms - p. 387 75. 9. Rehabilitation - p. 388 76. Chapter 26. Biomarkers for CNS Injury and Regeneration - p. 401 77. Chapter 27. High-Content Screening Applied to Nervous System Injury: Advantages, Challenges, and Proof of Principle - p. 411 78. Index - p. 421
Neural Regeneration provides an overview of cutting-edge knowledge on a broad spectrum of neural regeneration, including:
The contributors to this book are experts in their fields and work at distinguished institutions in the United States, Canada, Australia, and China.
Nervous system injuries, including peripheral nerve injuries, brain and spinal cord injuries, and stroke affect millions of people worldwide every year. As a result of this high incidence of neurological injuries, neural regeneration and repair is becoming a rapidly growing field dedicated to the new discoveries to promote structural and functional recoveries based on neural regeneration. The ultimate goal is to translate the most optimal regenerative strategies to treatments of human nervous system injuries.
This valuable reference book is useful for students, postdoctors, and basic and clinical scientists who are interested in neural regeneration research.
1. Section I. Introduction - p. xv 2. Chapter 1. Advances and Challenges for Neural Regeneration Research - p. 3 3. 1. Nervous System, Nerve Injury, and Neural Regeneration - p. 3 4. 2. Technological Advances in Neural Regeneration Research - p. 3 5. 3. PNS Regeneration - p. 5 6. 4. CNS Regeneration - p. 6 7. 5. Challenges and Opportunities - p. 9 8. Section II. Neural Regeneration in Lower Vertebrates - p. 17 9. Chapter 2. Functional Regeneration and Remyelination in the Zebrafish Optic Nerve - p. 21 10. 1. Introduction to Zebrafish Optic Nerve Injury (ONI) as a Model for Studying Regeneration and Remyelination - p. 21 11. 2. Time Course of Optic Nerve Regeneration in Adult Zebrafish - p. 21 12. 3. Intrinsic and Extrinsic Mechanisms of Axon Regeneration - p. 24 13. 4. Genetic Manipulation Tools Are Very Useful for Studying Regeneration in Zebrafish - p. 27 14. 5. In vivo Imaging of Nerve Regeneration in Zebrafish Larvae - p. 28 15. 6. Imaging Remyelination in Zebrafish - p. 30 16. 7. Behavior Tests Indexed the Visual Functional Recovery after Optic Nerve Injury - p. 32 17. 8. Future Directions - p. 33 18. 9. Conclusions - p. 33 19. Chapter 3. Central Nerve Regeneration in Reptiles - p. 43 20. Chapter 4. Axon Regeneration in the Lamprey Spinal Cord - p. 57 21. Section III. Neural Regeneration in the Peripheral Nervous System - p. 70 22. Chapter 5. Tissue Engineering in Peripheral Nerve Regeneration - p. 73 23. 1. Introduction - p. 73 24. 2. Nerve Scaffolds - p. 73 25. 3. Support Cells - p. 79 26. 4. Growth Factors - p. 82 27. 5. Clinical Applications - p. 86 28. 6. Concluding Remarks - p. 86 29. Chapter 6. Brachial Plexus Avulsion: A Model for Axonal Regeneration Study - p. 101 30. Chapter 7. Conditions Affecting Accuracy of Peripheral Nerve Reinnervation and Functional Recovery - p. 117 31. Chapter 8. Gonadal Steroids in Regeneration and Repair of Neuromuscular Systems - p. 129 32. Section IV. Neural Regeneration in the CNS - p. 150 33. Chapter 9. Myelin-Associated Inhibitors in Axonal Growth after Central Nervous System Injury - p. 153 34. Chapter 10. The Nogo Receptor Pathway in Central Nervous System Axon Regeneration and Therapeutic Opportunities - p. 171 35. Chapter 11. Astrogliosis and Axonal Regeneration - p. 181 36. Chapter 12. The Intrinsic Determinants of Axon Regeneration in the Central Nervous System - p. 197 37. Chapter 13. Optic Nerve Regeneration in Lower Vertebrates and Mammals: Bridging the Gap - p. 209 38. 1. Introduction - p. 209 39. 2. Cell Viability - p. 209 40. 3. Glial-Derived Inhibitors of Axon Growth - p. 211 41. 4. Control of the Regenerative State by Cell-Intrinsic and Cell-Extrinsic Factors - p. 212 42. 5. Intraocular Inflammation and Oncomodulin - p. 215 43. 6. Cell Signaling Pathways for Axon Regeneration of Retinal Ganglion Cells - p. 217 44. 7. Axon Guidance - p. 218 45. 8. Restoration of Central Visual Circuits and Partial Recovery of Visual Responses in Mammals - p. 219 46. 9. Future Prospects - p. 220 47. Chapter 14. Self-Assembling Peptides Mediate Neural Regeneration - p. 229 48. Chapter 15. Wnt Signaling in Spinal Cord Injury - p. 237 49. Chapter 16. Inflammation and Secondary Damage after Spinal Cord Injury - p. 245 50. Chapter 17. Neuroprotection of Retinal Ganglion Cells in Glaucoma by Blocking LINGO-1 Function or Using a Nogo-66 Receptor Antagonist - p. 263 51. Chapter 18. Axonal Regeneration in the Sensory Dorsal Column Pathway - p. 273 52. Section V. Transplantation-Mediated Neural Regeneration - p. 287 53. Chapter 19. Peripheral Nerve Graft-Mediated Axonal Regeneration - p. 291 54. Chapter 20. Transplantation of Olfactory Ensheathing Cells for Neural Repair - p. 301 55. 1. Introduction - p. 301 56. 2. Contribution of OECs to Olfactory Axon Regeneration - p. 301 57. 3. Basic Biology of the Regeneration-Promoting Properties of OECs - p. 302 58. 4. OEC-Mediated Transplantation for Neural Repair in Animal Studies - p. 306 59. 5. OEC-Mediated Transplantation in Clinical Trials - p. 311 60. 6. Concluding Remarks - p. 312 61. Chapter 21. Glial Precursor Cell Transplantation-Mediated Regeneration after Spinal Cord Injury Repair - p. 321 62. Chapter 22. Schwann Cell-Mediated Axonal Regeneration in the Central Nervous System - p. 337 63. Chapter 23. Fetal Spinal Cord Transplantation after Spinal Cord Injury: Around and Back Again - p. 351 64. Section VI. Clinical and Translational Research on Neural Regeneration - p. 365 65. Chapter 24. Spinal Cord Injury: Exercise and Clinical Trials - p. 369 66. Chapter 25. Spinal Cord Regeneration - p. 383 67. 1. Introduction - p. 383 68. 2. Axon Growth Inhibitor Theory - p. 383 69. 3. Glial Scar Theory - p. 384 70. 4. Growth Limitation Theory - p. 385 71. 5. Regenerative Therapies - p. 385 72. 6. Cell Transplants - p. 386 73. 7. Combination Therapies - p. 387 74. 8. Recovery Mechanisms - p. 387 75. 9. Rehabilitation - p. 388 76. Chapter 26. Biomarkers for CNS Injury and Regeneration - p. 401 77. Chapter 27. High-Content Screening Applied to Nervous System Injury: Advantages, Challenges, and Proof of Principle - p. 411 78. Index - p. 421
