Neuroglia in the Healthy Nervous System, Part I provides insights into newly emerging developments in neuroglia biology, focusing on the healthy nervous system. Driven by advances in genetics, transcriptomics, electrophysiological, and imaging techniques, this volume bridges the gap between neuroglia basic science and neuroglia clinical research. The book provides an overview of neuroglia biology, highlighting emerging technologies used to unravel the role of neuroglial cells in specific brain functions. The book also discusses strategies using neuroglia as a therapeutic target.
1. Introduction - p. 229 2. Mammalian Animal Models: Mus musculus and Rattus norvegicus - p. 230 3. The Impact of Primary Cell Cultures - p. 231 4. Generation of constitutive knock-out models for in vivo glia research - p. 233 5. Conditional Knock-Out Models: Overcoming Limitations of Constitutive Knock-Outs in Neuroscience Research - p. 235 6. Conditional Knock-Out Models With Temporal Control - p. 240 7. Constitutive and Conditional Expression of Reporter Genes - p. 243 8. The Advantages of Viral Gene Transduction - p. 246 9. Using the Versatility of Zebrafish as a Model System for Studying CNS Development and Glial Physiology - p. 247 10. Exploring Glial Physiology and Disease Susceptibility in Drosophila melanogaster - p. 250 11. Conclusion - p. 251 12. References - p. 252 13. Chapter 15 Single-cell omics and heterogeneity of neuroglial cells - p. 265 14. Chapter 16 Imaging neuroglia - p. 277 15. Index - p. 293
Neuroglia in the Healthy Nervous System, Part I provides insights into newly emerging developments in neuroglia biology, focusing on the healthy nervous system. Driven by advances in genetics, transcriptomics, electrophysiological, and imaging techniques, this volume bridges the gap between neuroglia basic science and neuroglia clinical research. The book provides an overview of neuroglia biology, highlighting emerging technologies used to unravel the role of neuroglial cells in specific brain functions. The book also discusses strategies using neuroglia as a therapeutic target.
1. Introduction - p. 229 2. Mammalian Animal Models: Mus musculus and Rattus norvegicus - p. 230 3. The Impact of Primary Cell Cultures - p. 231 4. Generation of constitutive knock-out models for in vivo glia research - p. 233 5. Conditional Knock-Out Models: Overcoming Limitations of Constitutive Knock-Outs in Neuroscience Research - p. 235 6. Conditional Knock-Out Models With Temporal Control - p. 240 7. Constitutive and Conditional Expression of Reporter Genes - p. 243 8. The Advantages of Viral Gene Transduction - p. 246 9. Using the Versatility of Zebrafish as a Model System for Studying CNS Development and Glial Physiology - p. 247 10. Exploring Glial Physiology and Disease Susceptibility in Drosophila melanogaster - p. 250 11. Conclusion - p. 251 12. References - p. 252 13. Chapter 15 Single-cell omics and heterogeneity of neuroglial cells - p. 265 14. Chapter 16 Imaging neuroglia - p. 277 15. Index - p. 293
