New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma.
The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment.
1. Chapter 1 : Introduction: A brief outlook into glioblastoma diagnosis and therapeutics - p. Page xiv 2. Chapter 2 : Practice guidelines for the diagnosis of glioblastoma - p. Page 5 3. Chapter 3 : Identification of potential biomarkers in glioblastoma through omics technologies and big data analysis - p. Page 28 4. Chapter 4 : Forging a path to the use of liquid biopsy in the diagnosis of gliomas - p. Page 49 5. Chapter 5 : Secretome analysis of patient-derived glioblastoma cells for potential biomarker identification - p. Page 74 6. Chapter 6 : Newly diagnosed glioblastoma: A review on clinical management - p. Page 93 7. Chapter 7 : Current status in brain glioblastoma imaging (MRI, CT-Scan) - p. Page 118 8. Chapter 8 : Combined PET/MRI in brain glioma imaging - p. Page 150 9. Chapter 9 : New surgical approaches in glioblastoma - p. Page 163 10. Chapter 10 : The role of radiogenomics - p. Page 184 11. Chapter 11 : An overview of molecular targeting of glioblastoma - p. Page 201 12. Chapter 12 : Terpenes: A hope for glioblastoma patients - p. Page 223 13. Chapter 13 : Artificial intelligence to speed up active compounds screening - p. Page 261 14. Chapter 14 : Repurposing drugs in glioblastoma - p. Page 281 15. Chapter 15 : Glioblastoma heterogeneity and resistance: A glance in biology and therapeutic approach - p. Page 302 16. Chapter 16 : Targeting DNA damage response pathways in glioblastoma: From mechanistic insights to advances in the clinic - p. Page 336 17. Chapter 17 : Alkaloids: Their relevance in cancer treatment - p. Page 357 18. Chapter 18 : An overview of current drug delivery strategies for glioblastoma treatment and barriers to progress - p. Page 389 19. Chapter 19 : Nanotechnology-based approaches in glioblastoma treatment: How can the dual blood-brain/tumor barriers be overcome? - p. Page 425 20. Chapter 20 : Non-coding RNAs in glioblastoma at a glance - p. Page 467 21. Chapter 21 : The role of vaccines in glioblastoma—Updated clinical results - p. Page 495 22. Chapter 22 : Dendritic cells and glioblastoma - p. Page 512 23. Chapter 23 : Cancer stem cells in glioblastoma – an update - p. Page 532 24. Chapter 24 : Optimizing the role of immunotherapy for the treatment of glioblastoma - p. Page 550 25. Chapter 25 : The role of exosomes in glioblastoma treatment - p. Page 578 26. Chapter 26 : Theranostic in glioblastoma - p. Page 606 27. Chapter 27 : Potential theranostic targets in glioblastoma - p. Page 628 28. Chapter 28 : Radiopharmaceuticals for molecular imaging and theranostics of glioblastoma - p. Page 657 29. Chapter 29 : Theranostic strategies to potentiate glioblastoma treatment via nanotechnology: The example of gold nanoparticles - p. Page 695 30. Chapter 30 : The effect of glioblastoma microenvironment on therapeutic, diagnostic, or theranostic systems - p. Page 723 31. Index - p. Page 743
New Insights into Glioblastoma: Diagnosis, Therapeutics and Theranostics provides a compendium of recent diagnostic and therapeutic advances in GBM, encompassing a pipeline of compounds and (bio) nanotechnology strategies that have stood out with potential increased antitumoral activity and capability to cross the blood-brain barrier. Issues and challenges related to their translation into the clinical practice and their contribution to the increase in survival rates and well-being of patients are addressed. This is a valuable resource for graduate students, oncologists, cancer researchers and members of the biomedical field who need to learn more on recent developments on the management of glioblastoma.
The book is split in three parts: Diagnosis, focusing on biomarkers and techniques such PET/MRI, infrared thermography, and deep neural networks; Therapeutics, discussing new chemical entities, as natural products and repurposed drugs, and new formulation approaches, as nanotechnology-based and microRNA approaches; and Theranostics, explaining the role of omics, system-based approaches, and glioblastoma microenvironment.
1. Chapter 1 : Introduction: A brief outlook into glioblastoma diagnosis and therapeutics - p. Page xiv 2. Chapter 2 : Practice guidelines for the diagnosis of glioblastoma - p. Page 5 3. Chapter 3 : Identification of potential biomarkers in glioblastoma through omics technologies and big data analysis - p. Page 28 4. Chapter 4 : Forging a path to the use of liquid biopsy in the diagnosis of gliomas - p. Page 49 5. Chapter 5 : Secretome analysis of patient-derived glioblastoma cells for potential biomarker identification - p. Page 74 6. Chapter 6 : Newly diagnosed glioblastoma: A review on clinical management - p. Page 93 7. Chapter 7 : Current status in brain glioblastoma imaging (MRI, CT-Scan) - p. Page 118 8. Chapter 8 : Combined PET/MRI in brain glioma imaging - p. Page 150 9. Chapter 9 : New surgical approaches in glioblastoma - p. Page 163 10. Chapter 10 : The role of radiogenomics - p. Page 184 11. Chapter 11 : An overview of molecular targeting of glioblastoma - p. Page 201 12. Chapter 12 : Terpenes: A hope for glioblastoma patients - p. Page 223 13. Chapter 13 : Artificial intelligence to speed up active compounds screening - p. Page 261 14. Chapter 14 : Repurposing drugs in glioblastoma - p. Page 281 15. Chapter 15 : Glioblastoma heterogeneity and resistance: A glance in biology and therapeutic approach - p. Page 302 16. Chapter 16 : Targeting DNA damage response pathways in glioblastoma: From mechanistic insights to advances in the clinic - p. Page 336 17. Chapter 17 : Alkaloids: Their relevance in cancer treatment - p. Page 357 18. Chapter 18 : An overview of current drug delivery strategies for glioblastoma treatment and barriers to progress - p. Page 389 19. Chapter 19 : Nanotechnology-based approaches in glioblastoma treatment: How can the dual blood-brain/tumor barriers be overcome? - p. Page 425 20. Chapter 20 : Non-coding RNAs in glioblastoma at a glance - p. Page 467 21. Chapter 21 : The role of vaccines in glioblastoma—Updated clinical results - p. Page 495 22. Chapter 22 : Dendritic cells and glioblastoma - p. Page 512 23. Chapter 23 : Cancer stem cells in glioblastoma – an update - p. Page 532 24. Chapter 24 : Optimizing the role of immunotherapy for the treatment of glioblastoma - p. Page 550 25. Chapter 25 : The role of exosomes in glioblastoma treatment - p. Page 578 26. Chapter 26 : Theranostic in glioblastoma - p. Page 606 27. Chapter 27 : Potential theranostic targets in glioblastoma - p. Page 628 28. Chapter 28 : Radiopharmaceuticals for molecular imaging and theranostics of glioblastoma - p. Page 657 29. Chapter 29 : Theranostic strategies to potentiate glioblastoma treatment via nanotechnology: The example of gold nanoparticles - p. Page 695 30. Chapter 30 : The effect of glioblastoma microenvironment on therapeutic, diagnostic, or theranostic systems - p. Page 723 31. Index - p. Page 743
