New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management provides crucial insights for developing ideal synthetic opioids. It discusses opioid receptor modulators’ structures and mechanisms, and their potential applications in treating pain, misuse, and addiction. This comprehensive resource delves into current research and therapeutic development avenues regarding opioid receptors' structure and function. Sections cover the rationale for developing allosteric modulators, identifying allosteric sites on opioid receptors, and the modulators' modes of action. Readers will gain a thorough understanding of creating ideal synthetic opioids and potential future research.
It also explores pharmacogenomics, precision medicine, and various syndromes and comorbidities linked to opioid use. Lastly, it reviews novel synthetic opioids and the risks of misuse and overdose.
1. Introduction - p. 85 2. Opioid receptor neurobiology - p. 86 3. Neuromodulators of opioid use disorder - p. 88 4. Sex and gender influences on opioid use disorder - p. 98 5. Further considerations and remaining questions - p. 100 6. Chapter 10. Opioid receptor modulator/synthetic opioids and risk of dependency: Responsibility of healthcare workers, manufacturers, and pharmacists - p. 121 7. Chapter 11. Center for disease control and prevention (CDC) guidelines of chronic pain in the adult, including newer guidelines against coprescription with benzodiazepines - p. 129 8. Chapter 12. Commonly prescribed opioids and adjuvants in acute and chronic pain management - p. 135 9. Chapter 13. Opioids in clinical practice: From punitive to partnership - p. 157 10. Introduction - p. 157 11. Fentanyl: The fourth wave - p. 160 12. Opioids in vivo: Use, misuse, abuse, dependence, and disorder - p. 162 13. Treatment of opioid use disorder - p. 165 14. Buprenorphine - p. 170 15. OUD in practice - p. 178 16. Ethical considerations - p. 184 17. Health disparities - p. 184 18. Chapter 14. The role of naltrexone and novel preparations for substance abuse and pain management - p. 193 19. Chapter 15. Palliative care for cancer and considerations for opioid-mediated suppression of natural killer cells - p. 201 20. Chapter 16. Abuse deterrent formulations of opioids and opioid vaccines - p. 205 21. Chapter 17. Opioid detoxification techniques - p. 215 22. Index - p. 221
New Opioid Receptor Modulators and Agonists: Relevance for Pain and Opioid Use Disorder Management provides crucial insights for developing ideal synthetic opioids. It discusses opioid receptor modulators’ structures and mechanisms, and their potential applications in treating pain, misuse, and addiction. This comprehensive resource delves into current research and therapeutic development avenues regarding opioid receptors' structure and function. Sections cover the rationale for developing allosteric modulators, identifying allosteric sites on opioid receptors, and the modulators' modes of action. Readers will gain a thorough understanding of creating ideal synthetic opioids and potential future research.
It also explores pharmacogenomics, precision medicine, and various syndromes and comorbidities linked to opioid use. Lastly, it reviews novel synthetic opioids and the risks of misuse and overdose.
1. Introduction - p. 85 2. Opioid receptor neurobiology - p. 86 3. Neuromodulators of opioid use disorder - p. 88 4. Sex and gender influences on opioid use disorder - p. 98 5. Further considerations and remaining questions - p. 100 6. Chapter 10. Opioid receptor modulator/synthetic opioids and risk of dependency: Responsibility of healthcare workers, manufacturers, and pharmacists - p. 121 7. Chapter 11. Center for disease control and prevention (CDC) guidelines of chronic pain in the adult, including newer guidelines against coprescription with benzodiazepines - p. 129 8. Chapter 12. Commonly prescribed opioids and adjuvants in acute and chronic pain management - p. 135 9. Chapter 13. Opioids in clinical practice: From punitive to partnership - p. 157 10. Introduction - p. 157 11. Fentanyl: The fourth wave - p. 160 12. Opioids in vivo: Use, misuse, abuse, dependence, and disorder - p. 162 13. Treatment of opioid use disorder - p. 165 14. Buprenorphine - p. 170 15. OUD in practice - p. 178 16. Ethical considerations - p. 184 17. Health disparities - p. 184 18. Chapter 14. The role of naltrexone and novel preparations for substance abuse and pain management - p. 193 19. Chapter 15. Palliative care for cancer and considerations for opioid-mediated suppression of natural killer cells - p. 201 20. Chapter 16. Abuse deterrent formulations of opioids and opioid vaccines - p. 205 21. Chapter 17. Opioid detoxification techniques - p. 215 22. Index - p. 221
