Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. iv 5. Dedication - p. v 6. About the author - p. xi 7. Preface - p. xiii 8. Chapter One: nAChR structure - p. 1 9. Chapter Two: Neuronal nAChR localization, subtype diversity, and evolution - p. 23 10. Chapter Three: Function and pharmacology of neuronal nAChRs - p. 41 11. Chapter Four: Nicotine addiction: The role of specific nAChR subtypes and treatments - p. 71 12. Chapter Five: Disease associations—Alzheimer’s disease, schizophrenia, Parkinson’s disease, autism, and cancer - p. 95 13. Chapter Six: Role of neuronal nAChRs in normal development and plasticity - p. 147 14. Chapter Seven: Developmental, epigenetic, and possible transgenerational effects of smoking and vaping - p. 167 15. Chapter Eight: Expression and function of nonneuronal nAChRs - p. 189 16. Chapter Nine: Regulation of nAChR expression: Posttranscriptional regulation of nAChRs - p. 213 17. Chapter Ten: Nonmammalian models for studying nAChRs; zebrafish, fruit fly, and worm. What have we learned? - p. 235 18. Index - p. 269
Nicotinic Acetylcholine Receptors in Health and Disease provides the latest information Nicotinic acetylcholine receptors (nAChRs), which are involved in numerous diseases, including Alzheimer’s, Parkinson’s, and schizophrenia, and are important potential translational targets for treatment of these diseases, as well as therapy for addiction. This book focuses on the roles and function of nAChRs inside and outside of the nervous system, with an emphasis on translational implications and future prospects for the treatment of numerous disorders. This greater understanding of the basic neurobiology and clinical roles of nAChRs provides important insights for future clinical treatments of many major disorders.
1. Cover image - p. i 2. Title page - p. i 3. Table of Contents - p. i 4. Copyright - p. iv 5. Dedication - p. v 6. About the author - p. xi 7. Preface - p. xiii 8. Chapter One: nAChR structure - p. 1 9. Chapter Two: Neuronal nAChR localization, subtype diversity, and evolution - p. 23 10. Chapter Three: Function and pharmacology of neuronal nAChRs - p. 41 11. Chapter Four: Nicotine addiction: The role of specific nAChR subtypes and treatments - p. 71 12. Chapter Five: Disease associations—Alzheimer’s disease, schizophrenia, Parkinson’s disease, autism, and cancer - p. 95 13. Chapter Six: Role of neuronal nAChRs in normal development and plasticity - p. 147 14. Chapter Seven: Developmental, epigenetic, and possible transgenerational effects of smoking and vaping - p. 167 15. Chapter Eight: Expression and function of nonneuronal nAChRs - p. 189 16. Chapter Nine: Regulation of nAChR expression: Posttranscriptional regulation of nAChRs - p. 213 17. Chapter Ten: Nonmammalian models for studying nAChRs; zebrafish, fruit fly, and worm. What have we learned? - p. 235 18. Index - p. 269
