Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs.
With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of pharmacology, biochemistry, cell and molecular biology, chemistry, immunology, neurobiology, immunology, nutrition sciences, drug development and the clinical management of both acute and chronic diseases.
1. Introduction and Overview - p. xv 2. Chapter 1: A Concise History of the Discovery of Mammalian Nitric Oxide (Nitrogen Monoxide) Biogenesis - p. xxii 3. Chapter 2: An Integrated View of the Chemical Biology of NO, CO, H2S, and O2 - p. 7 4. Chapter 3: Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review - p. 21 5. Chapter 4: S-Nitrosothiols and Nitric Oxide Biology - p. 44 6. Chapter 5: Cooperative Interactions Between NO and H2S: Chemistry, Biology, Physiology, Pathophysiology - p. 56 7. Chapter 6: Heme Protein Metabolism of NO and Nitrite - p. 83 8. Chapter 7: Cross-Regulation Between iNOS/NO and Wnt/β-Catenin Signaling Pathways - p. 96 9. Chapter 8: Regulation and Physiological Functions of NO-Sensitive Guanylyl Cyclase - p. 105 10. Chapter 9: Uncoupling of eNOS in Cardiovascular Disease - p. 116 11. Chapter 10: Synthesis, Actions, and Perspectives of Nitric Oxide in Photosynthetic Organisms - p. 124 12. Chapter 11: Mitochondria and Nitric Oxide - p. 136 13. Chapter 12: Nitric Oxide Formation From Inorganic Nitrate - p. 156 14. Chapter 13: Biochemistry of Molybdopterin Nitrate/Nitrite Reductases - p. 171 15. Chapter 14: NOS, NO, and the Red Cell - p. 184 16. Chapter 15: Update on Nitrite Reduction in Ischemic Disease: Mechanisms and Clinical Translation - p. 194 17. Chapter 16: Electrophilic Nitro-Fatty Acids: Nitric Oxide and Nitrite-Derived Metabolic and Inflammatory Signaling Mediators - p. 211 18. Chapter 17: Regulation of Redox Signaling by a Nitrated Nucleotide and Reactive Cysteine Persulfides - p. 229 19. Chapter 18: Diffusional Control of Nitric Oxide in the Vessel Wall - p. 235 20. Chapter 19: Asymmetric-Dimethylarginine - p. 246 21. Chapter 20: Mechanisms of Epigenetic Regulation by Nitric Oxide - p. 254 22. Chapter 21: Peroxynitrite Formation and Detection in Living Cells - p. 270 23. Chapter 22: Nitric Oxide in Sepsis and Hemorrhagic Shock: Beneficial or Detrimental? - p. 288 24. Chapter 23: NO Signaling Defects in Hypertension - p. 300 25. Chapter 24: Nitric Oxide Regulation of Cardiovascular Physiology and Pathophysiology - p. 311 26. Chapter 25: Inhaled Nitric Oxide—Current Practice and Future Potential Uses and Development - p. 338 27. Chapter 26: The Defective Arginine-Nitric Oxide Pathway in Sickle Cell Disease - p. 353 28. Chapter 27: Aberrant Nitric Oxide Signaling Contributes to Protein Misfolding in Neurodegenerative Diseases via S-Nitrosylation and Tyrosine Nitration - p. 371 29. Chapter 28: NO in Cancer—Carcinogenesis, Metastasis, and Therapy - p. 384 30. Index - p. 402
Nitric Oxide: Biology and Pathobiology, Third Edition, provides information on nitric oxide, a signaling molecule of key importance for the cardiovascular system that regulates blood pressure and blood flow to different organs.
With recent links to the role of nitric oxide in the expression of healthy benefits of controlled diet and aerobic exercise, and the reactions of nitric oxide that can impact cell signaling, this book provides a comprehensive resource during a time when increased research attention is being paid across the fields of pharmacology, biochemistry, cell and molecular biology, chemistry, immunology, neurobiology, immunology, nutrition sciences, drug development and the clinical management of both acute and chronic diseases.
1. Introduction and Overview - p. xv 2. Chapter 1: A Concise History of the Discovery of Mammalian Nitric Oxide (Nitrogen Monoxide) Biogenesis - p. xxii 3. Chapter 2: An Integrated View of the Chemical Biology of NO, CO, H2S, and O2 - p. 7 4. Chapter 3: Detection of Nitric Oxide and Peroxynitrite in Biological Systems: A State-of-the-Art Review - p. 21 5. Chapter 4: S-Nitrosothiols and Nitric Oxide Biology - p. 44 6. Chapter 5: Cooperative Interactions Between NO and H2S: Chemistry, Biology, Physiology, Pathophysiology - p. 56 7. Chapter 6: Heme Protein Metabolism of NO and Nitrite - p. 83 8. Chapter 7: Cross-Regulation Between iNOS/NO and Wnt/β-Catenin Signaling Pathways - p. 96 9. Chapter 8: Regulation and Physiological Functions of NO-Sensitive Guanylyl Cyclase - p. 105 10. Chapter 9: Uncoupling of eNOS in Cardiovascular Disease - p. 116 11. Chapter 10: Synthesis, Actions, and Perspectives of Nitric Oxide in Photosynthetic Organisms - p. 124 12. Chapter 11: Mitochondria and Nitric Oxide - p. 136 13. Chapter 12: Nitric Oxide Formation From Inorganic Nitrate - p. 156 14. Chapter 13: Biochemistry of Molybdopterin Nitrate/Nitrite Reductases - p. 171 15. Chapter 14: NOS, NO, and the Red Cell - p. 184 16. Chapter 15: Update on Nitrite Reduction in Ischemic Disease: Mechanisms and Clinical Translation - p. 194 17. Chapter 16: Electrophilic Nitro-Fatty Acids: Nitric Oxide and Nitrite-Derived Metabolic and Inflammatory Signaling Mediators - p. 211 18. Chapter 17: Regulation of Redox Signaling by a Nitrated Nucleotide and Reactive Cysteine Persulfides - p. 229 19. Chapter 18: Diffusional Control of Nitric Oxide in the Vessel Wall - p. 235 20. Chapter 19: Asymmetric-Dimethylarginine - p. 246 21. Chapter 20: Mechanisms of Epigenetic Regulation by Nitric Oxide - p. 254 22. Chapter 21: Peroxynitrite Formation and Detection in Living Cells - p. 270 23. Chapter 22: Nitric Oxide in Sepsis and Hemorrhagic Shock: Beneficial or Detrimental? - p. 288 24. Chapter 23: NO Signaling Defects in Hypertension - p. 300 25. Chapter 24: Nitric Oxide Regulation of Cardiovascular Physiology and Pathophysiology - p. 311 26. Chapter 25: Inhaled Nitric Oxide—Current Practice and Future Potential Uses and Development - p. 338 27. Chapter 26: The Defective Arginine-Nitric Oxide Pathway in Sickle Cell Disease - p. 353 28. Chapter 27: Aberrant Nitric Oxide Signaling Contributes to Protein Misfolding in Neurodegenerative Diseases via S-Nitrosylation and Tyrosine Nitration - p. 371 29. Chapter 28: NO in Cancer—Carcinogenesis, Metastasis, and Therapy - p. 384 30. Index - p. 402
