Nitrogen Heterocycles in Cancer Therapy offers an in-depth exploration of the latest nitrogen-containing heterocyclic compounds used in the fight against cancer. Across ten chapters, the book lays a solid foundation in oncology while delving into the design, synthesis, and anticancer mechanisms of these compounds. Drawing from current research, it examines how these molecules are engineered to target cancer cells, and highlights both in-vitro and in-vivo evaluation techniques. Through clear explanations and detailed analysis, the book provides readers with a comprehensive understanding of molecular strategies and promising new agents shaping modern cancer therapy.
In addition to covering the science behind these compounds, the book presents clinical study reports demonstrating their effectiveness across various cancer types. It also discusses the global market impact, pharmacoeconomics, and future directions for drug development. By integrating the latest advancements and practical insights, this work stands out as an invaluable resource for researchers, clinicians, and students seeking to stay at the forefront of innovative cancer treatments.
1. Chapter 1. Introduction to heterocyclic nucleus-based nitrogen-containing anticancer compounds - p. 1 2. Chapter 2. Three and four-member nitrogen-containing heterocyclic compounds as anticancer agents - p. 19 3. Chapter 3. Five membered nitrogen-containing heterocyclic compounds (pyrrole and pyrazole derivatives) as anticancer compounds - p. 37 4. Chapter 4. Six-membered nitrogen-containing heterocyclic compounds (pyridine, pyrimidine, piperidine, and triazine) as anticancer compounds - p. 73 5. Chapter 5. Azoles (triazole and imidazole) scaffolds in anticancer drug design - p. 93 6. Chapter 6. Purine derivatives in cancer therapy - p. 143 7. Chapter 7. REMOVED: Indole scaffolds in anticancer drug discovery - p. 175 8. Chapter 8. Benzimidazole, benzothiazole, and benzoxazole derivatives as potential anticancer agents - p. 191 9. Chapter 9. Quinoline, isoquinoline, and quinoxaline derivatives as promising anticancer agents - p. 205 10. Chapter 10. Miscellaneous fused heterocyclic compounds (β-lactam derivatives, carbazoles, isatin derivatives, pyrrolo-benzodiazepines, pyrido[2,3-d] pyrimidine derivatives) as anticancer compounds - p. 223 11. Index - p. 239
Nitrogen Heterocycles in Cancer Therapy offers an in-depth exploration of the latest nitrogen-containing heterocyclic compounds used in the fight against cancer. Across ten chapters, the book lays a solid foundation in oncology while delving into the design, synthesis, and anticancer mechanisms of these compounds. Drawing from current research, it examines how these molecules are engineered to target cancer cells, and highlights both in-vitro and in-vivo evaluation techniques. Through clear explanations and detailed analysis, the book provides readers with a comprehensive understanding of molecular strategies and promising new agents shaping modern cancer therapy.
In addition to covering the science behind these compounds, the book presents clinical study reports demonstrating their effectiveness across various cancer types. It also discusses the global market impact, pharmacoeconomics, and future directions for drug development. By integrating the latest advancements and practical insights, this work stands out as an invaluable resource for researchers, clinicians, and students seeking to stay at the forefront of innovative cancer treatments.
1. Chapter 1. Introduction to heterocyclic nucleus-based nitrogen-containing anticancer compounds - p. 1 2. Chapter 2. Three and four-member nitrogen-containing heterocyclic compounds as anticancer agents - p. 19 3. Chapter 3. Five membered nitrogen-containing heterocyclic compounds (pyrrole and pyrazole derivatives) as anticancer compounds - p. 37 4. Chapter 4. Six-membered nitrogen-containing heterocyclic compounds (pyridine, pyrimidine, piperidine, and triazine) as anticancer compounds - p. 73 5. Chapter 5. Azoles (triazole and imidazole) scaffolds in anticancer drug design - p. 93 6. Chapter 6. Purine derivatives in cancer therapy - p. 143 7. Chapter 7. REMOVED: Indole scaffolds in anticancer drug discovery - p. 175 8. Chapter 8. Benzimidazole, benzothiazole, and benzoxazole derivatives as potential anticancer agents - p. 191 9. Chapter 9. Quinoline, isoquinoline, and quinoxaline derivatives as promising anticancer agents - p. 205 10. Chapter 10. Miscellaneous fused heterocyclic compounds (β-lactam derivatives, carbazoles, isatin derivatives, pyrrolo-benzodiazepines, pyrido[2,3-d] pyrimidine derivatives) as anticancer compounds - p. 223 11. Index - p. 239
