Nucleic Acids: A Natural Target for Newly Designed Metal Chelate Based Drugs discusses how human diseases are becoming more costly to treat, along with updates on the resistance offered by disease-causing agents. The abundance of drugs in the market has provided great relief to patients, but side effects can destroy the immune system of the body. Patients need to boost their immune system, and at the same time cover expenses incurred to cure disease. Thus, a paradigm shift is needed to design a drug molecule with low cost and easy availability.
Metal complexes can be a great example of such a shift, as metal ions are components of biological molecules and can achieve good binding capability to specific targets while not allowing them to damage healthy cell system. Therefore, in this book, a comprehensive compilation of recent data is provided, including the structural elucidation of metal complexes by advanced techniques and the binding pattern of metal complexes with specific targets.
1. Nucleic Acids - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. List of contributors - p. ix 8. Abbreviations - p. xi 9. Chapter 1 Zinc complexes - p. 1 10. Chapter 2 Ruthenium complexes - p. 43 11. Chapter 3 Nucleic acid interactions of copper complexes - p. 95 12. Chapter 4 Recent advances in iron complexes and their interaction with nucleic acids - p. 145 13. Chapter 5 Manganese complexes - p. 189 14. Index - p. 227
Nucleic Acids: A Natural Target for Newly Designed Metal Chelate Based Drugs discusses how human diseases are becoming more costly to treat, along with updates on the resistance offered by disease-causing agents. The abundance of drugs in the market has provided great relief to patients, but side effects can destroy the immune system of the body. Patients need to boost their immune system, and at the same time cover expenses incurred to cure disease. Thus, a paradigm shift is needed to design a drug molecule with low cost and easy availability.
Metal complexes can be a great example of such a shift, as metal ions are components of biological molecules and can achieve good binding capability to specific targets while not allowing them to damage healthy cell system. Therefore, in this book, a comprehensive compilation of recent data is provided, including the structural elucidation of metal complexes by advanced techniques and the binding pattern of metal complexes with specific targets.
1. Nucleic Acids - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. iv 6. Dedication - p. v 7. List of contributors - p. ix 8. Abbreviations - p. xi 9. Chapter 1 Zinc complexes - p. 1 10. Chapter 2 Ruthenium complexes - p. 43 11. Chapter 3 Nucleic acid interactions of copper complexes - p. 95 12. Chapter 4 Recent advances in iron complexes and their interaction with nucleic acids - p. 145 13. Chapter 5 Manganese complexes - p. 189 14. Index - p. 227
