Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders.
Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.
1. Section I. Introduction - p. xxiii 2. Chapter 1. Introduction to nutritional epigenomics - p. 3 3. Section II. Epigenetic regulators - p. 10 4. Chapter 2. DNA methylation and chromatin modifications - p. 13 5. Chapter 3. Small non-coding RNAs as epigenetic regulators - p. 37 6. Section III. Epigenomic regulation of disease - p. 47 7. Chapter 4. The impact of race and ethnicity in the social epigenomic regulation of disease - p. 51 8. Chapter 5. The epigenomic impact of methylation in metabolic dysfunction and cancer - p. 67 9. Chapter 6. The role for DNA/RNA methylation on neurocognitive dysfunctions - p. 85 10. Chapter 7. Histone acylation in the epigenomic regulation of insulin action and metabolic disease - p. 101 11. Chapter 8. Cancer and non-coding RNAs - p. 119 12. Section IV. Nutrition, epigenetics and transgenerational inheritance - p. 132 13. Chapter 9. Race in the social-epigenomic regulation of pre- and perinatal development - p. 135 14. Chapter 10. Maternal nutrition, epigenetic programming and metabolic syndrome - p. 153 15. Chapter 11. Epigenetic inheritance of metabolic signals - p. 167 16. Chapter 12. The paternal diet regulates the offspring epigenome and health - p. 191 17. Section V. Nutritional epigenomics and the circadian clock - p. 200 18. Chapter 13. The interplay between diet, epigenetics and the circadian clock - p. 203 19. Chapter 14. Epigenetic regulation of the fetal circadian clock: Implications for nutritional programming of circadian and metabolic function - p. 211 20. Chapter 15. The role for the microbiome in the regulation of the circadian clock and metabolism - p. 231 21. Section VI. Carloric restriction and exercise in the epigenomic regulation of aging and disease - p. 248 22. Chapter 16. Epigenomic reprogramming of caloric restriction on aging - p. 251 23. Chapter 17. Dietary restriction in the epigenomic regulation of cardiovascular diseases - p. 269 24. Chapter 18. Epigenomic adaptations of exercise in the control of metabolic disease and cancer - p. 289 25. Section VII. Macro- and micronutrients as epigenomic regulators of health and disease - p. 316 26. Chapter 19. B-vitamins & one-carbon metabolism: Impacts on the epigenome during development - p. 319 27. Chapter 20. Food bioactives in the epigenomic regulation of metabolic disease - p. 337 28. Chapter 21. Stilbenoids as dietary regulators of the cancer epigenome - p. 353 29. Chapter 22. Regulation of non-coding RNAs by phytochemicals for cancer therapy - p. 371 30. Chapter 23. Short chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and disease - p. 381 31. Section VIII. Diet, epigenetics and the microbiome - p. 397 32. Chapter 24. Diet-microbiome interactions and the regulation of the epigenome - p. 401 33. Chapter 25. Gut dysbiosis and its epigenomic impact on disease - p. 409 34. Chapter 26. Microbiota, the brain and epigenetics - p. 423 35. Index - p. 445
Nutritional Epigenomics offers a comprehensive overview of nutritional epigenomics as a mode of study, along with nutrition’s role in the epigenomic regulation of disease, health and developmental processes. Here, an expert team of international contributors introduces readers to nutritional epigenomic regulators of gene expression, our diet’s role in epigenomic regulation of disease and disease inheritance, caloric restriction and exercise as they relate to recent epigenomic findings, and the influence of nutritional epigenomics over circadian rhythms, aging and longevity, and fetal health and development, among other processes. Disease specific chapters address metabolic disease (obesity and diabetes), cancer, and neurodegeneration, among other disorders.
Diet-gut microbiome interactions in the epigenomic regulation of disease are also discussed, as is the role of micronutrients and milk miRNAs in epigenetic regulation. Finally, chapter authors examine ongoing discussions of race and ethnicity in the social-epigenomic regulation of health and disease.
1. Section I. Introduction - p. xxiii 2. Chapter 1. Introduction to nutritional epigenomics - p. 3 3. Section II. Epigenetic regulators - p. 10 4. Chapter 2. DNA methylation and chromatin modifications - p. 13 5. Chapter 3. Small non-coding RNAs as epigenetic regulators - p. 37 6. Section III. Epigenomic regulation of disease - p. 47 7. Chapter 4. The impact of race and ethnicity in the social epigenomic regulation of disease - p. 51 8. Chapter 5. The epigenomic impact of methylation in metabolic dysfunction and cancer - p. 67 9. Chapter 6. The role for DNA/RNA methylation on neurocognitive dysfunctions - p. 85 10. Chapter 7. Histone acylation in the epigenomic regulation of insulin action and metabolic disease - p. 101 11. Chapter 8. Cancer and non-coding RNAs - p. 119 12. Section IV. Nutrition, epigenetics and transgenerational inheritance - p. 132 13. Chapter 9. Race in the social-epigenomic regulation of pre- and perinatal development - p. 135 14. Chapter 10. Maternal nutrition, epigenetic programming and metabolic syndrome - p. 153 15. Chapter 11. Epigenetic inheritance of metabolic signals - p. 167 16. Chapter 12. The paternal diet regulates the offspring epigenome and health - p. 191 17. Section V. Nutritional epigenomics and the circadian clock - p. 200 18. Chapter 13. The interplay between diet, epigenetics and the circadian clock - p. 203 19. Chapter 14. Epigenetic regulation of the fetal circadian clock: Implications for nutritional programming of circadian and metabolic function - p. 211 20. Chapter 15. The role for the microbiome in the regulation of the circadian clock and metabolism - p. 231 21. Section VI. Carloric restriction and exercise in the epigenomic regulation of aging and disease - p. 248 22. Chapter 16. Epigenomic reprogramming of caloric restriction on aging - p. 251 23. Chapter 17. Dietary restriction in the epigenomic regulation of cardiovascular diseases - p. 269 24. Chapter 18. Epigenomic adaptations of exercise in the control of metabolic disease and cancer - p. 289 25. Section VII. Macro- and micronutrients as epigenomic regulators of health and disease - p. 316 26. Chapter 19. B-vitamins & one-carbon metabolism: Impacts on the epigenome during development - p. 319 27. Chapter 20. Food bioactives in the epigenomic regulation of metabolic disease - p. 337 28. Chapter 21. Stilbenoids as dietary regulators of the cancer epigenome - p. 353 29. Chapter 22. Regulation of non-coding RNAs by phytochemicals for cancer therapy - p. 371 30. Chapter 23. Short chain fatty acids as epigenetic and metabolic regulators of neurocognitive health and disease - p. 381 31. Section VIII. Diet, epigenetics and the microbiome - p. 397 32. Chapter 24. Diet-microbiome interactions and the regulation of the epigenome - p. 401 33. Chapter 25. Gut dysbiosis and its epigenomic impact on disease - p. 409 34. Chapter 26. Microbiota, the brain and epigenetics - p. 423 35. Index - p. 445
