Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scientific importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine β-synthase, and Oligomerization of Porphobilinogen Synthase.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface - p. page_xiii 7. Chapter One: Fluorescence microscopy methods for the study of protein oligomerization - p. page_xv 8. Chapter Two: Computational prediction and redesign of aberrant protein oligomerization - p. page_41 9. Chapter Three: Porphobilinogen synthase: An equilibrium of different assemblies in human health - p. page_83 10. Chapter Four: Prediction and targeting of GPCR oligomer interfaces - p. page_104 11. Chapter Five: Integrated structural modeling and super-resolution imaging resolve GPCR oligomers - p. page_149 12. Chapter Six: Exploring functional consequences of GPCR oligomerization requires a different lens - p. page_179 13. Chapter Seven: Continuing challenges in targeting oligomeric GPCR-based drugs - p. page_211 14. Chapter Eight: Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives - p. page_245 15. Chapter Nine: Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action - p. page_277 16. Chapter Ten: Oligomerization of G protein-coupled receptors: Still doubted? - p. page_296 17. Index - p. page_323
Oligomerization in Health and Disease: From Enzymes to G Protein-Coupled Receptors, Volume 169 in the Progress in Molecular Biology and Translational Science series, provides in-depth reviews on topics of exceptional scientific importance. Topics of note in this new release include Computational prediction and re-design of aberrant oligomerization, Oligomerization of G protein-coupled receptors: an historical overview, Prediction and targeting of GPCR oligomer interfaces, GPCR Oligomerization dynamics: Functional consequences, GPCR heteromerization in neuropsychiatric disorders, Structural basis of regulation and oligomerization of human cystathionine β-synthase, and Oligomerization of Porphobilinogen Synthase.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Contributors - p. page_ix 6. Preface - p. page_xiii 7. Chapter One: Fluorescence microscopy methods for the study of protein oligomerization - p. page_xv 8. Chapter Two: Computational prediction and redesign of aberrant protein oligomerization - p. page_41 9. Chapter Three: Porphobilinogen synthase: An equilibrium of different assemblies in human health - p. page_83 10. Chapter Four: Prediction and targeting of GPCR oligomer interfaces - p. page_104 11. Chapter Five: Integrated structural modeling and super-resolution imaging resolve GPCR oligomers - p. page_149 12. Chapter Six: Exploring functional consequences of GPCR oligomerization requires a different lens - p. page_179 13. Chapter Seven: Continuing challenges in targeting oligomeric GPCR-based drugs - p. page_211 14. Chapter Eight: Adenosine A2A-dopamine D2 receptor-receptor interaction in neurons and astrocytes: Evidence and perspectives - p. page_245 15. Chapter Nine: Genetic variants in dopamine receptors influence on heterodimerization in the context of antipsychotic drug action - p. page_277 16. Chapter Ten: Oligomerization of G protein-coupled receptors: Still doubted? - p. page_296 17. Index - p. page_323
