Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport.
Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource.
1. Oral Delivery of Therapeutic Peptides and Proteins - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. v 6. List of Contributors - p. xi 7. About the Editors - p. xiii 8. Foreword - p. xv 9. Preface - p. xvii 10. Acknowledgments - p. xix 11. Chapter one Landscape for oral delivery of peptides - p. 1 12. Chapter two Design and synthesis of chemically modified peptides and proteins —critical considerations for oral delivery - p. 51 13. Chapter Three A biopharmaceutics perspective on oral peptide developability and drug delivery - p. 87 14. Chapter four Nanoparticle-assisted oral delivery of small and large peptides - p. 131 15. Chapter five Novel formulation approaches for gastrointestinal targeting: characterization and animal model considerations - p. 167 16. Chapter six CMC Considerations for conventional oral peptide formulations. Scale up and validation - p. 199 17. Chapter seven Clinical translation of oral peptide delivery technologies - p. 225 18. Chapter eight Regulatory aspects of oral peptide delivery - p. 251 19. Index - p. 291
Oral Delivery of Therapeutic Peptides and Proteins provides a complete overview of the journey scientists pursue to attain protein and peptide oral delivery. The book highlights the physiological challenges that must be accounted for in addition to overcoming protease inhibition and acid stability issues that are commonly mentioned in this area of research. Primary topics include formulation technologies being adopted for oral delivery of proteins and peptides, modification of actives to make them more suited for oral delivery, animal models and their shortcomings in assessing oral bioavailability, and in vitro models to simulate drug absorption and transport.
Academics and industry researchers working in formulation development and researchers and advanced students in biotechnology and pharmacy will find this a useful resource.
1. Oral Delivery of Therapeutic Peptides and Proteins - p. i 2. Cover - p. i 3. Title Page - p. iii 4. Copyright - p. iv 5. Table of Contents - p. v 6. List of Contributors - p. xi 7. About the Editors - p. xiii 8. Foreword - p. xv 9. Preface - p. xvii 10. Acknowledgments - p. xix 11. Chapter one Landscape for oral delivery of peptides - p. 1 12. Chapter two Design and synthesis of chemically modified peptides and proteins —critical considerations for oral delivery - p. 51 13. Chapter Three A biopharmaceutics perspective on oral peptide developability and drug delivery - p. 87 14. Chapter four Nanoparticle-assisted oral delivery of small and large peptides - p. 131 15. Chapter five Novel formulation approaches for gastrointestinal targeting: characterization and animal model considerations - p. 167 16. Chapter six CMC Considerations for conventional oral peptide formulations. Scale up and validation - p. 199 17. Chapter seven Clinical translation of oral peptide delivery technologies - p. 225 18. Chapter eight Regulatory aspects of oral peptide delivery - p. 251 19. Index - p. 291
