OrthoBiologics provides state-of-the-art knowledge of current biologic therapies for a variety of orthopaedic conditions in a single source. The content is presented in a straightforward manner, including defining all currently available orthobiologic options, discussing processing characteristics and appropriate clinical use, and finally, summarizing clinical applications and outcomes as well as future potential directions.
In addition to covering current approaches and applications, the editors aim for this book to present “best practices” for those practicing and researching orthopaedic pathologies and orthobiologic treatments, including blood and cellular based therapies. The editors are world-renown experts in the field and this book fills a gap in the market.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Dedication - p. v 7. List of contributors - p. xi 8. Preface - p. xv 9. Chapter 1. Autologous blood: platelet-rich plasma and platelet-poor plasma - p. 1 10. Chapter 2. Defining, measuring and optimizing platelet-rich plasma - p. 13 11. Chapter 3. Optimal use of platelet-rich plasma and platelet-poor plasma - p. 23 12. Chapter 4. Where orthobiologics started: what are mesenchymal stem cells? - p. 31 13. Chapter 5. Bone marrow-derived mesenchymal stromal cells - p. 39 14. Chapter 6. Defining, optimizing, and measuring bone marrow aspirate and bone marrow concentrate - p. 47 15. Chapter 7. Optimal clinical use of bone marrow aspirate and bone marrow aspirate concentrate - p. 61 16. Chapter 8. Adipose tissue-derived stromal/stem cells - p. 73 17. Chapter 9. Defining, optimizing, measuring, and utilizing adipose, MFAT, etc. - p. 81 18. Chapter 10. Optimal clinical use of adipose mesenchymal stromal cells - p. 97 19. Chapter 11. Basic science and preclinical evidence for amniotic membrane−derived allografts in orthobiologics - p. 111 20. Chapter 12. Defining, optimizing, and measuring amniotic/placental mesenchymal stem cells - p. 121 21. Chapter 13. Optimal clinical use of amniotic/placental mesenchymal stem cells - p. 129 22. Chapter 14. Synovial mesenchymal stem cells - p. 141 23. Chapter 15. Peripheral blood stem cells - p. 155 24. Chapter 16. Orthobiologics—growth factors and mediators - p. 179 25. Chapter 17. Orthobiologics in the procedure room—who, what, where, when, and how - p. 191 26. Chapter 18. Orthobiologics in the operating room—who, what, where, when, and how - p. 203 27. Chapter 19. The changing regulatory environment: regulations and restrictions - p. 215 28. Chapter 20. Bioscaffolds for osteochondral injuries of the knee - p. 221 29. Chapter 21. Orthobiologics on the horizon - p. 235 30. Chapter 22. Complications associated with orthobiologics - p. 249 31. Index - p. 255
OrthoBiologics provides state-of-the-art knowledge of current biologic therapies for a variety of orthopaedic conditions in a single source. The content is presented in a straightforward manner, including defining all currently available orthobiologic options, discussing processing characteristics and appropriate clinical use, and finally, summarizing clinical applications and outcomes as well as future potential directions.
In addition to covering current approaches and applications, the editors aim for this book to present “best practices” for those practicing and researching orthopaedic pathologies and orthobiologic treatments, including blood and cellular based therapies. The editors are world-renown experts in the field and this book fills a gap in the market.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Dedication - p. v 7. List of contributors - p. xi 8. Preface - p. xv 9. Chapter 1. Autologous blood: platelet-rich plasma and platelet-poor plasma - p. 1 10. Chapter 2. Defining, measuring and optimizing platelet-rich plasma - p. 13 11. Chapter 3. Optimal use of platelet-rich plasma and platelet-poor plasma - p. 23 12. Chapter 4. Where orthobiologics started: what are mesenchymal stem cells? - p. 31 13. Chapter 5. Bone marrow-derived mesenchymal stromal cells - p. 39 14. Chapter 6. Defining, optimizing, and measuring bone marrow aspirate and bone marrow concentrate - p. 47 15. Chapter 7. Optimal clinical use of bone marrow aspirate and bone marrow aspirate concentrate - p. 61 16. Chapter 8. Adipose tissue-derived stromal/stem cells - p. 73 17. Chapter 9. Defining, optimizing, measuring, and utilizing adipose, MFAT, etc. - p. 81 18. Chapter 10. Optimal clinical use of adipose mesenchymal stromal cells - p. 97 19. Chapter 11. Basic science and preclinical evidence for amniotic membrane−derived allografts in orthobiologics - p. 111 20. Chapter 12. Defining, optimizing, and measuring amniotic/placental mesenchymal stem cells - p. 121 21. Chapter 13. Optimal clinical use of amniotic/placental mesenchymal stem cells - p. 129 22. Chapter 14. Synovial mesenchymal stem cells - p. 141 23. Chapter 15. Peripheral blood stem cells - p. 155 24. Chapter 16. Orthobiologics—growth factors and mediators - p. 179 25. Chapter 17. Orthobiologics in the procedure room—who, what, where, when, and how - p. 191 26. Chapter 18. Orthobiologics in the operating room—who, what, where, when, and how - p. 203 27. Chapter 19. The changing regulatory environment: regulations and restrictions - p. 215 28. Chapter 20. Bioscaffolds for osteochondral injuries of the knee - p. 221 29. Chapter 21. Orthobiologics on the horizon - p. 235 30. Chapter 22. Complications associated with orthobiologics - p. 249 31. Index - p. 255
