Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases.
Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Dedication - p. page_v 6. Contributors - p. page_xvii 7. Foreword - p. page_xxiii 8. Preface - p. page_xxv 9. Part I: Oxidative stress and neurological diseases - p. page_xxvi 10. Chapter 1: The role of reactive oxygen species in the pathogenic pathways of depression - p. page_xxvi 11. Chapter 2: The relationship between the blood-brain barrier, degenerative neuropathy, and oxidative stress - p. page_16 12. Chapter 3: Neuroinflammatory processes and oxidative stress - p. page_32 13. Chapter 4: Neuroinflammation and oxidative stress in the aging brain: Linking in metabolism, stem cells, proteostasis, and stress adaptation - p. page_47 14. Chapter 5: Neuroblastoma and oxidative stress: From pathogenesis to in vitro models of neurodegeneration - p. page_65 15. Chapter 6: Oxidative stress in epileptogenesis: Febrile seizures, chemoconvulsant pilocarpine, and electrical stimulation - p. page_79 16. Chapter 7: DJ-1 in astrocytic neuroprotection to oxidative stress - p. page_94 17. Chapter 8: Oxidative stress markers in seizures and epilepsy: Methods and applications to models - p. page_108 18. Part II: Antioxidants and neurological diseases - p. page_122 19. Chapter 9: Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants - p. page_122 20. Chapter 10: Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil - p. page_141 21. Chapter 11: Aromatic plants: A source of compounds with antioxidant and neuroprotective effects - p. page_154 22. Chapter 12: The elderly, use of antioxidants and memory - p. page_173 23. Chapter 13: Aspidosperma pyrifolium Mart. antioxidants features and neuronal tissues - p. page_188 24. Chapter 14: Berberine neuroprotection and antioxidant activity - p. page_198 25. Chapter 15: Carnosic acid and carnosol: Neuroprotection and the mitochondria - p. page_216 26. Chapter 16: Coconut oil and antioxidative neuroprotection - p. page_230 27. Chapter 17: Antioxidant effects of Curcuma longa and its active constituent, curcumin, for the therapy of neurological disorders - p. page_247 28. Chapter 18: Neuroprotective mechanisms of Ginkgo biloba against oxidative stress - p. page_269 29. Chapter 19: Morinda citrifolia Linn. (Noni) fruit, antioxidant effects, and neuroprotection - p. page_290 30. Chapter 20: Naringin and naringenin in neuroprotection and oxidative stress - p. page_307 31. Chapter 21: Nigella sativa L. and thymoquinone as neuroprotective antioxidants - p. page_323 32. Chapter 22: Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol - p. page_341 33. Chapter 23: The role of saffron and its main components on oxidative stress in neurological diseases: A review - p. page_357 34. Chapter 24: Sulforaphane and its modulation of brain redox status: The mitochondria as a target - p. page_375 35. Chapter 25: Recommended resources for oxidative stress and dietary antioxidants in neurological diseases - p. page_391 36. Index - p. page_399
Oxidative Stress and Dietary Antioxidants in Neurological Diseases provides an overview of oxidative stress in neurological diseases and associated conditions, including behavioral aspects and the potentially therapeutic usage of natural antioxidants in the diet. The processes within the science of oxidative stress are described in concert with other processes, such as apoptosis, cell signaling, and receptor mediated responses. This approach recognizes that diseases are often multifactorial and oxidative stress is a single component of this. The book examines basic processes of oxidative stress—from molecular biology to whole organs—relative to cellular defense systems, and across a range of neurological diseases.
Sections discuss antioxidants in foods, including plants and components of the diet, examining the underlying mechanisms associated with therapeutic potential and clinical applications. Although some of this material is exploratory or preclinical, it can provide the framework for further in-depth analysis or studies via well-designed clinical trials or the analysis of pathways, mechanisms, and components in order to devise new therapeutic strategies. Very often oxidative stress is a feature of neurological disease and associated conditions which either centers on or around molecular and cellular processes. Oxidative stress can also arise due to nutritional imbalance during a spectrum of timeframes before the onset of disease or during its development.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. Dedication - p. page_v 6. Contributors - p. page_xvii 7. Foreword - p. page_xxiii 8. Preface - p. page_xxv 9. Part I: Oxidative stress and neurological diseases - p. page_xxvi 10. Chapter 1: The role of reactive oxygen species in the pathogenic pathways of depression - p. page_xxvi 11. Chapter 2: The relationship between the blood-brain barrier, degenerative neuropathy, and oxidative stress - p. page_16 12. Chapter 3: Neuroinflammatory processes and oxidative stress - p. page_32 13. Chapter 4: Neuroinflammation and oxidative stress in the aging brain: Linking in metabolism, stem cells, proteostasis, and stress adaptation - p. page_47 14. Chapter 5: Neuroblastoma and oxidative stress: From pathogenesis to in vitro models of neurodegeneration - p. page_65 15. Chapter 6: Oxidative stress in epileptogenesis: Febrile seizures, chemoconvulsant pilocarpine, and electrical stimulation - p. page_79 16. Chapter 7: DJ-1 in astrocytic neuroprotection to oxidative stress - p. page_94 17. Chapter 8: Oxidative stress markers in seizures and epilepsy: Methods and applications to models - p. page_108 18. Part II: Antioxidants and neurological diseases - p. page_122 19. Chapter 9: Antioxidant therapy, oxidative stress, and blood-brain barrier: The road of dietary antioxidants - p. page_122 20. Chapter 10: Antioxidant and neuroprotective properties of Mediterranean oils: Argan oil, olive oil, and milk thistle seed oil - p. page_141 21. Chapter 11: Aromatic plants: A source of compounds with antioxidant and neuroprotective effects - p. page_154 22. Chapter 12: The elderly, use of antioxidants and memory - p. page_173 23. Chapter 13: Aspidosperma pyrifolium Mart. antioxidants features and neuronal tissues - p. page_188 24. Chapter 14: Berberine neuroprotection and antioxidant activity - p. page_198 25. Chapter 15: Carnosic acid and carnosol: Neuroprotection and the mitochondria - p. page_216 26. Chapter 16: Coconut oil and antioxidative neuroprotection - p. page_230 27. Chapter 17: Antioxidant effects of Curcuma longa and its active constituent, curcumin, for the therapy of neurological disorders - p. page_247 28. Chapter 18: Neuroprotective mechanisms of Ginkgo biloba against oxidative stress - p. page_269 29. Chapter 19: Morinda citrifolia Linn. (Noni) fruit, antioxidant effects, and neuroprotection - p. page_290 30. Chapter 20: Naringin and naringenin in neuroprotection and oxidative stress - p. page_307 31. Chapter 21: Nigella sativa L. and thymoquinone as neuroprotective antioxidants - p. page_323 32. Chapter 22: Dietary antioxidants, epigenetics, and brain aging: A focus on resveratrol - p. page_341 33. Chapter 23: The role of saffron and its main components on oxidative stress in neurological diseases: A review - p. page_357 34. Chapter 24: Sulforaphane and its modulation of brain redox status: The mitochondria as a target - p. page_375 35. Chapter 25: Recommended resources for oxidative stress and dietary antioxidants in neurological diseases - p. page_391 36. Index - p. page_399
