Pancreatic B Cell Biology in Health and Disease, Volume 360 presents the latest release in this ongoing series on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This new volume includes new chapters on a variety of topics, including Pancreatic Beta Cell Dysfunction in Type 1 Diabetes: The Role of Ifn, Sexual Hormones and Diabetes: The Impact in Pancreatic Beta Cell, Pancreatic Beta Cell Dysfunction in Monogenic Diabetes, The Role of MiRNAs In Beta Cell Function, Pancreatic Beta Cell: How Environmental Endocrine Disruptors Alter Its Function, Enteroviral Infections and Pancreatic Beta Cell Dysfunction, and more.
Final sections cover Long Non-Coding Rna-Regulated Pathways in Pancreatic Beta Cell: Their Role in Diabetes and Pancreatic Beta Cell Biology in Health and Disease.
1. 1 Introduction - p. 2 2. 2 Type I interferons - p. 3 3. 3 Pancreatic β-cell dysfunction in T1D - p. 9 4. 4 Viruses as triggers of IFNα response in β-cells - p. 17 5. 5 Candidate genes and type I IFN signaling pathway - p. 24 6. 6 Type I IFNs in T1D pathogenesis - p. 32 7. 7 Targeting type I IFN production and/or signaling as potential therapeutic approaches - p. 45 8. 8 Concluding remarks - p. 51 9. References - p. 53 10. Chapter Two: Sexual hormones and diabetes: The impact of estradiol in pancreatic β cell - p. 104 11. Chapter Three: Molecular mechanisms of β-cell dysfunction and death in monogenic forms of diabetes - p. 144 12. Abstract - p. 140 13. Abbreviations - p. 141 14. 1 Introduction - p. 142 15. 2 Monogenic forms of diabetes associated with mutations in transcription factors and transcriptional regulators - p. 147 16. 3 Monogenic forms of diabetes associated with impaired glucose metabolism and insulin secretion - p. 177 17. 4 Monogenic forms of diabetes associated with endoplasmic reticulum stress - p. 188 18. 5 Monogenic forms of diabetes associated with mitochondrial dysfunction - p. 203 19. 6 Monogenic forms of diabetes associated with impaired tRNA methylation - p. 207 20. 7 Concluding remarks - p. 210 21. References - p. 211 22. Chapter Four: Role of microRNA in pancreatic beta cell function - p. 257 23. Chapter Five: Physiology of pancreatic β-cells: Ion channels and molecular mechanisms implicated in stimulus-secretion coupling - p. 287 24. Chapter Six: Long non-coding RNA-regulated pathways in pancreatic β cells: Their role in diabetes - p. 325 25. Chapter Seven: Molecular mechanisms of lipotoxicity-induced pancreatic β-cell dysfunction - p. 357
Pancreatic B Cell Biology in Health and Disease, Volume 360 presents the latest release in this ongoing series on the novel and widely studied physiology of pancreatic cells in homeostasis and under pathogenic conditions. This new volume includes new chapters on a variety of topics, including Pancreatic Beta Cell Dysfunction in Type 1 Diabetes: The Role of Ifn, Sexual Hormones and Diabetes: The Impact in Pancreatic Beta Cell, Pancreatic Beta Cell Dysfunction in Monogenic Diabetes, The Role of MiRNAs In Beta Cell Function, Pancreatic Beta Cell: How Environmental Endocrine Disruptors Alter Its Function, Enteroviral Infections and Pancreatic Beta Cell Dysfunction, and more.
Final sections cover Long Non-Coding Rna-Regulated Pathways in Pancreatic Beta Cell: Their Role in Diabetes and Pancreatic Beta Cell Biology in Health and Disease.
1. 1 Introduction - p. 2 2. 2 Type I interferons - p. 3 3. 3 Pancreatic β-cell dysfunction in T1D - p. 9 4. 4 Viruses as triggers of IFNα response in β-cells - p. 17 5. 5 Candidate genes and type I IFN signaling pathway - p. 24 6. 6 Type I IFNs in T1D pathogenesis - p. 32 7. 7 Targeting type I IFN production and/or signaling as potential therapeutic approaches - p. 45 8. 8 Concluding remarks - p. 51 9. References - p. 53 10. Chapter Two: Sexual hormones and diabetes: The impact of estradiol in pancreatic β cell - p. 104 11. Chapter Three: Molecular mechanisms of β-cell dysfunction and death in monogenic forms of diabetes - p. 144 12. Abstract - p. 140 13. Abbreviations - p. 141 14. 1 Introduction - p. 142 15. 2 Monogenic forms of diabetes associated with mutations in transcription factors and transcriptional regulators - p. 147 16. 3 Monogenic forms of diabetes associated with impaired glucose metabolism and insulin secretion - p. 177 17. 4 Monogenic forms of diabetes associated with endoplasmic reticulum stress - p. 188 18. 5 Monogenic forms of diabetes associated with mitochondrial dysfunction - p. 203 19. 6 Monogenic forms of diabetes associated with impaired tRNA methylation - p. 207 20. 7 Concluding remarks - p. 210 21. References - p. 211 22. Chapter Four: Role of microRNA in pancreatic beta cell function - p. 257 23. Chapter Five: Physiology of pancreatic β-cells: Ion channels and molecular mechanisms implicated in stimulus-secretion coupling - p. 287 24. Chapter Six: Long non-coding RNA-regulated pathways in pancreatic β cells: Their role in diabetes - p. 325 25. Chapter Seven: Molecular mechanisms of lipotoxicity-induced pancreatic β-cell dysfunction - p. 357
