Use the veterinarian’s #1 reference on general pathology and the pathology of organ systems! Pathologic Basis of Veterinary Disease, 7th Edition helps you understand and diagnose diseases of domestic animals by using the latest scientific and medical research. Focusing on dogs, cats horses, cattle, sheep, goats, and pigs, this reference describes and vividly illustrates and explores the pathogeneses of animal diseases, how cells and tissues respond to injury, and the morphology (lesions) of this injury. New to this edition is basic coverage of tumor, inflammatory, and microbial cytology. Edited by veterinary pathologist James F. Zachary and a team of expert veterinary pathologists, this book includes access to an enhanced eBook with every new print purchase, featuring a fully searchable version of the entire text, an image collection, and much more – and available on a variety of devices.
1. Introduction. Fundamentals for Understanding Veterinary Pathology - p. 1 2. Section I. Cellular and Molecular Mechanisms of Disease (General Pathology) - p. P1 3. Introduction - p. 15 4. Chapter 1. Mechanisms and Morphology of Cellular Injury, Adaptation, and Deatha - p. 16 5. Introduction - p. 16 6. Normal Cell - p. 16 7. Causes of Cell Injury - p. 22 8. Irreversible Cell Injury and Cell Death - p. 26 9. Chronic Cell Injury and Cell Adaptations - p. 36 10. Cell Cycle - p. 56 11. Cellular Aging - p. 57 12. Genetic Basis of Diseasek - p. 59 13. Chapter 2. Vascular Disorders and Thrombosisa - p. 74 14. Chapter 3. Inflammation and Healinga - p. 104 15. Introduction - p. 104 16. Evolution of the Current Understanding of Inflammation - p. 104 17. Beneficial and Harmful Aspects of Inflammation - p. 106 18. Acute Inflammation - p. 106 19. Substances Inducing the Acute Inflammatory Response - p. 109 20. Fluidic (Exudative) Phase of the Acute Inflammatory Response - p. 110 21. Cellular Phase of the Acute Inflammatory Response - p. 112 22. Additional Regulation of Inflammation - p. 114 23. Inflammation and Pain - p. 114 24. Effector Cells of the Acute Inflammatory Response - p. 114 25. Chemical Mediators of the Acute Inflammatory Response - p. 121 26. Reparative Phase of the Acute Inflammatory Response - p. 134 27. Nomenclature of the Inflammatory Response (Morphologic Diagnoses) - p. 135 28. Morphologic Classification of Exudates in Acute Inflammatory Lesions - p. 136 29. Chronic Inflammation - p. 138 30. Beneficial and Harmful Aspects of Chronic Inflammation - p. 139 31. Progression of the Acute Inflammatory Response to Chronic Inflammation, Fibrosis, and Abscess Formation - p. 140 32. Gross and Microscopic Lesions and Nomenclature of the Chronic Inflammatory Response - p. 146 33. Effector Cells and Cellular Mechanisms of Chronic Inflammatory Responses - p. 148 34. Inflammation and the Sensation of Pain - p. 154 35. The Effect of Inflammation on the Febrile Response and Other Activities - p. 154 36. Unique Types of Inflammation - p. 154 37. Cytologic and Histologic Comparisons of Inflammatory Exudates - p. 155 38. Wound Healing and Angiogenesis - p. 157 39. Chapter 4. Mechanisms of Microbial Infectionsa - p. 171 40. Introduction - p. 171 41. Chronologic Sequence of Steps in Microbial Diseases - p. 171 42. Portals of Entry - p. 173 43. Target Cells and Substances - p. 177 44. Pathways of Spread - p. 179 45. Defense Mechanisms - p. 184 46. Genetic Resistance of Animals to Infectious Diseases - p. 188 47. Bacterial Diseases - p. 189 48. Viral Diseases - p. 237 49. Morphology of Viruses - p. 237 50. Target Cells - p. 237 51. Viral Pathogenicity and Replication Cycle - p. 238 52. Virulence Factors - p. 240 53. Mechanisms of Genomic Change - p. 241 54. Defense Mechanisms - p. 243 55. Viral Diseases of Organ Systems - p. 243 56. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal Cavity - p. 243 57. Hepatobiliary System and Exocrine Pancreas - p. 251 58. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae - p. 252 59. Cardiovascular System and Lymphatic Vessels - p. 258 60. Bone Marrow, Blood Cells, and Lymphoid/Lymphatic System - p. 264 61. Nervous System - p. 268 62. Bone, Joints, Ligaments, and Tendons - p. 274 63. Integumentary System - p. 274 64. Female Reproductive System and Mammae - p. 277 65. Male Reproductive System - p. 279 66. The Eye - p. 279 67. Fungal Diseases (Mycoses) - p. 279 68. Protozoan Diseases - p. 287 69. Prion Diseases (Spongiform Encephalopathies) - p. 292 70. Chapter 5. Diseases of Immunitya - p. 295 71. General Features of the Immune System - p. 295 72. Innate Immunity (Nonspecific Immunity) - p. 295 73. Adaptive Immunity (Specific Immunity) - p. 299 74. Disorders of the Immune System - p. 313 75. Chapter 6. Neoplasia and Tumor Biologya - p. 341 76. Introduction - p. 341 77. General Nomenclature - p. 341 78. Tumor Characteristics (Essential Concept 6.1) - p. 345 79. Neoplastic Transformation (Essential Concept 6.2) - p. 352 80. Tumor Microenvironment (Essential Concept 6.3) - p. 354 81. Tumor Immunity (see Essential Concept 6.3) - p. 358 82. Tumor Dissemination (Essential Concept 6.4) - p. 362 83. Systemic Clinical Effects on the Animal (see Essential Concept 6.3) - p. 366 84. Heritable Alterations in Cancer (Essential Concept 6.5) - p. 368 85. Molecular Determinants of Cancer - p. 371 86. Mechanisms of Carcinogenesis - p. 375 87. Cancer in Animals - p. 376 88. Section II. Pathology of Organ Systems - p. P2 89. Introduction - p. 395 90. Chapter 7. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal CavityA detailed medical diagram showing A kidney filtering unit with blood vessels, filtering membrane, and small structural parts involved in urine formation.The image shows a detailed cross section drawing of A kidney filtering unit called a glomerulus inside a round capsule. At the top there is a blood vessel entering and another leaving, forming a small knot of capillary loops. Red blood cells are visible inside these tiny blood vessels. The capillary walls appear thin and are surrounded by supporting cells. Around the capillary loops there is a clear space that represents the area where filtered fluid collects before moving into a small tube at the bottom. The inner lining of the capsule is made of specialized cells with foot like extensions that wrap around the capillaries and help control filtration. A thicker central area contains supporting tissue and cells that hold the capillary loops together. The lower part shows a narrow tube where the filtered fluid flows out to form urine. The drawing uses soft colors to separate blood spaces, supporting cells, and surrounding capsule layers. This diagram explains how blood enters the glomerulus, fluid is filtered through thin walls, and waste fluid passes into the collecting space while blood cells remain inside the vessels.a - p. 396 91. Introduction - p. 396 92. Structureb and Function - p. 396 93. Dysfunction/Responses to Injury - p. 403 94. Portals of Entry/Pathways of Spread - p. 411 95. Defense Mechanisms/Barrier Systems - p. 415 96. Diseases Affecting Multiple Species of Domestic Animalsc,d - p. 417 97. Oral Cavity - p. 417 98. Teeth - p. 423 99. Tonsils - p. 424 100. Salivary Glands - p. 425 101. Tongue - p. 425 102. Esophagus - p. 427 103. Rumen, Reticulum, and Omasum - p. 431 104. Stomach and Abomasum - p. 431 105. Intestine - p. 439 106. Peritoneum, Omentum, Mesentery, and Peritoneal Cavity - p. 459 107. Diseases of Horses - p. 460 108. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 464 109. Diseases of Pigs - p. 475 110. Diseases of Dogs - p. 480 111. Diseases of Cats - p. 484 112. Chapter 8. Hepatobiliary System and Exocrine Pancreasa - p. 486 113. Liver and Intrahepatic Biliary System - p. 486 114. Structureb - p. 486 115. Embryologic Development - p. 491 116. Function - p. 491 117. Dysfunction/Responses to Injury - p. 493 118. Oncotic Necrosis and Apoptosis - p. 493 119. Morphologic Classification of Hepatobiliary Disease - p. 496 120. Disturbances of Bile Flow and Icterus - p. 498 121. Ductular Reaction (Biliary Hyperplasia) - p. 499 122. Regeneration - p. 500 123. Fibrosis - p. 500 124. End-Stage Liver or Cirrhosis - p. 502 125. Hepatic Failure - p. 504 126. Aging - p. 504 127. Portals of Entry/Pathways of Spread - p. 505 128. Defense Mechanisms/Barrier Systems - p. 505 129. Diseases Affecting Multiple Species of Domestic Animals - p. 506 130. Diseases of Horses - p. 527 131. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 529 132. Diseases of Pigs - p. 531 133. Diseases of Dogs - p. 532 134. Diseases of Cats - p. 535 135. Gallbladder and Extrahepatic Bile Ducts - p. 535 136. Exocrine Pancreas - p. 539 137. Chapter 9. Respiratory System, Thoracic Cavities, Mediastinum, and Pleuraea - p. 547 138. Introduction - p. 547 139. Structure and Function - p. 547 140. Dysfunction/Responses to Injury - p. 550 141. Portals of Entry/Pathways of Spread - p. 558 142. Defense Mechanisms/Barrier Systems - p. 558 143. Diseases Affecting Multiple Species of Domestic Animalsb - p. 563 144. Diseases of Horses - p. 598 145. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 606 146. Diseases of Pigs - p. 624 147. Diseases of Dogs - p. 630 148. Diseases of Cats - p. 638 149. Chapter 10. Cardiovascular System, Pericardial Cavity, and Lymphatic Vesselsa - p. 643 150. Structure - p. 643 151. Function - p. 647 152. Dysfunction/Responses to Injury - p. 649 153. Portals of Entry/Pathways of Spread - p. 661 154. Defense Mechanisms/Barrier Systems - p. 662 155. Diseases Affecting Multiple Species of Domestic Animals - p. 662 156. Diseases of Horses - p. 685 157. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 687 158. Diseases of Pigs - p. 688 159. Diseases of Dogs - p. 691 160. Diseases of Cats - p. 697 161. Chapter 11. The Urinary Systema - p. 699 162. Kidneyb - p. 699 163. Lower Urinary Tracte - p. 756 164. Chapter 12. Endocrine Systema - p. 767 165. Structure and Function - p. 767 166. Dysfunction/Responses to Injury - p. 777 167. Portals of Entry/Pathways of Spread - p. 779 168. Defense Mechanisms/Barrier Systems - p. 779 169. Diseases Affecting Multiple Species of Domestic Animalse - p. 780 170. Diseases of Horses - p. 799 171. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 800 172. Diseases of Pigs - p. 801 173. Diseases of Dogs - p. 801 174. Diseases of Cats - p. 805 175. Chapter13. Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic Systema - p. 809 176. Chapter 14. Nervous Systema - p. 892 177. The Nervous System - p. 892 178. Central Nervous System - p. 893 179. Peripheral Nervous System - p. 983 180. Chapter 15. Skeletal Musclea - p. 992 181. Structure - p. 992 182. Function - p. 993 183. Dysfunction/Responses to Injury - p. 997 184. Defense Mechanisms/Barrier Systems - p. 1007 185. Diseases Affecting Multiple Species of Domestic Animals - p. 1007 186. Diseases of Horses - p. 1016 187. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1024 188. Diseases of Pigs - p. 1028 189. Diseases of Dogs - p. 1029 190. Diseases of Cats - p. 1035 191. Chapter 16. Bones, Joints, Tendons, and Ligamentsa - p. 1037 192. Introduction - p. 1037 193. Structure and Function - p. 1037 194. Dysfunction/Responses to Injury - p. 1048 195. Portals of Entry/Pathways of Spread - p. 1055 196. Defense Mechanisms/Barrier Systems - p. 1056 197. Diseases Affecting Multiple Species of Domestic Animalsf - p. 1056 198. Diseases of Horses - p. 1091 199. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1091 200. Diseases of Pigs - p. 1091 201. Diseases of Dogs - p. 1091 202. Diseases of Cats - p. 1094 203. Chapter17. The Integumenta - p. 1095 204. Structure - p. 1095 205. Function - p. 1107 206. Dysfunction/Responses to Injury - p. 1108 207. Types of Clinical Skin Lesions - p. 1108 208. Diagnostic Procedures: Clinical Skin Lesions - p. 1122 209. Skin Biopsy Procedure - p. 1122 210. Patient Selection for Biopsy - p. 1122 211. Selection of Skin Lesions for Biopsy - p. 1123 212. Selection of Biopsy Site Based on the Type of Skin Lesion - p. 1123 213. Skin Biopsy Techniques - p. 1126 214. Artifacts - p. 1127 215. Skin Preparation - p. 1127 216. Tissue Fixation - p. 1127 217. History - p. 1127 218. Ancillary Procedures - p. 1127 219. Types (Patterns) of Histopathologic Skin Lesions - p. 1127 220. Regeneration and Repair - p. 1146 221. Portals of Entry/Pathways of Spread - p. 1146 222. Defense Mechanisms/Barrier Systems - p. 1148 223. Diseases Affecting Multiple Species of Domestic Animalsg - p. 1149 224. Congenital and Inherited Disorders - p. 1149 225. Disorders of Radiation, Chemical, or Physical Injury - p. 1154 226. Microbial and Parasitic Disorders - p. 1162 227. Viral Infections - p. 1162 228. Bacterial Infections - p. 1166 229. Fungal (Mycotic) Infections - p. 1173 230. Algal Infections - p. 1178 231. Parasitic Infections - p. 1178 232. Diseases of Horses - p. 1219 233. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1223 234. Diseases of Pigs - p. 1229 235. Diseases of Dogs - p. 1233 236. Diseases of Cats - p. 1256 237. Chapter 18. Female Reproductive System and Mammaea - p. 1263 238. Introduction - p. 1263 239. Structureb - p. 1263 240. Function - p. 1265 241. Dysfunction/Responses to Injury - p. 1266 242. Portals of Entry/Pathways of Spread - p. 1267 243. Defense Mechanisms/Barrier Systems - p. 1267 244. Diseases Affecting Multiple Species of Domestic Animals - p. 1270 245. Diseases of Horses - p. 1290 246. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1293 247. Diseases of Pigs - p. 1302 248. Diseases of Dogs - p. 1303 249. Diseases of Cats - p. 1307 250. Chapter 19. Male Reproductive Systema - p. 1308 251. Chapter 20. The Eara - p. 1336 252. Chapter 21. The Eyea - p. 1379 253. Introduction - p. 1379 254. Structure and Function - p. 1381 255. Dysfunction/Response to Injury - p. 1387 256. Portals of Entry/Pathways of Spread - p. 1397 257. Defense Mechanisms/Barrier Systems - p. 1399 258. Diseases Affecting Multiple Species of Domestic Animalsb - p. 1401 259. Diseases of Horses - p. 1424 260. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1426 261. Diseases of Pigs - p. 1427 262. Diseases of Dogs - p. 1427 263. Diseases of Cats - p. 1431 264. Section III: Appendices, Veterinary Diagnostic Pathology - p. rP1 265. Introduction∗ - p. 1435 266. Appendix A. Communication, Collaboration, and Consultation in Veterinary Pathology - p. e1 267. Appendix B. Photographic Techniques in Veterinary Pathology - p. e15 268. Appendix C. Postmortem Examination (Autopsy) of Domestic Animal Speciesa - p. e23 269. Appendix D. Recognition and Interpretation of Macroscopic (Gross) Lesions - p. e43 270. Appendix E. Diagnoses in Veterinary Pathologya - p. e85 271. Appendix F. General Principles of Tissue Fixation and Processing - p. e87 272. Appendix G. Fixatives and Fixation - p. e94 273. Appendix H. Fixation and Trimming of the Brain, Spinal Cord, and Nerves - p. e98 274. Appendix I. Surgical Biopsies—Procurement, Processing, and Sectioning Artifactsa - p. e104 275. Appendix J. Gross Examination and Infusion Fixation of the Lung - p. e105 276. Appendix K. Necropsy Techniques by Organ Systema - p. e109 277. Index - p. 1437
Use the veterinarian’s #1 reference on general pathology and the pathology of organ systems! Pathologic Basis of Veterinary Disease, 7th Edition helps you understand and diagnose diseases of domestic animals by using the latest scientific and medical research. Focusing on dogs, cats horses, cattle, sheep, goats, and pigs, this reference describes and vividly illustrates and explores the pathogeneses of animal diseases, how cells and tissues respond to injury, and the morphology (lesions) of this injury. New to this edition is basic coverage of tumor, inflammatory, and microbial cytology. Edited by veterinary pathologist James F. Zachary and a team of expert veterinary pathologists, this book includes access to an enhanced eBook with every new print purchase, featuring a fully searchable version of the entire text, an image collection, and much more – and available on a variety of devices.
1. Introduction. Fundamentals for Understanding Veterinary Pathology - p. 1 2. Section I. Cellular and Molecular Mechanisms of Disease (General Pathology) - p. P1 3. Introduction - p. 15 4. Chapter 1. Mechanisms and Morphology of Cellular Injury, Adaptation, and Deatha - p. 16 5. Introduction - p. 16 6. Normal Cell - p. 16 7. Causes of Cell Injury - p. 22 8. Irreversible Cell Injury and Cell Death - p. 26 9. Chronic Cell Injury and Cell Adaptations - p. 36 10. Cell Cycle - p. 56 11. Cellular Aging - p. 57 12. Genetic Basis of Diseasek - p. 59 13. Chapter 2. Vascular Disorders and Thrombosisa - p. 74 14. Chapter 3. Inflammation and Healinga - p. 104 15. Introduction - p. 104 16. Evolution of the Current Understanding of Inflammation - p. 104 17. Beneficial and Harmful Aspects of Inflammation - p. 106 18. Acute Inflammation - p. 106 19. Substances Inducing the Acute Inflammatory Response - p. 109 20. Fluidic (Exudative) Phase of the Acute Inflammatory Response - p. 110 21. Cellular Phase of the Acute Inflammatory Response - p. 112 22. Additional Regulation of Inflammation - p. 114 23. Inflammation and Pain - p. 114 24. Effector Cells of the Acute Inflammatory Response - p. 114 25. Chemical Mediators of the Acute Inflammatory Response - p. 121 26. Reparative Phase of the Acute Inflammatory Response - p. 134 27. Nomenclature of the Inflammatory Response (Morphologic Diagnoses) - p. 135 28. Morphologic Classification of Exudates in Acute Inflammatory Lesions - p. 136 29. Chronic Inflammation - p. 138 30. Beneficial and Harmful Aspects of Chronic Inflammation - p. 139 31. Progression of the Acute Inflammatory Response to Chronic Inflammation, Fibrosis, and Abscess Formation - p. 140 32. Gross and Microscopic Lesions and Nomenclature of the Chronic Inflammatory Response - p. 146 33. Effector Cells and Cellular Mechanisms of Chronic Inflammatory Responses - p. 148 34. Inflammation and the Sensation of Pain - p. 154 35. The Effect of Inflammation on the Febrile Response and Other Activities - p. 154 36. Unique Types of Inflammation - p. 154 37. Cytologic and Histologic Comparisons of Inflammatory Exudates - p. 155 38. Wound Healing and Angiogenesis - p. 157 39. Chapter 4. Mechanisms of Microbial Infectionsa - p. 171 40. Introduction - p. 171 41. Chronologic Sequence of Steps in Microbial Diseases - p. 171 42. Portals of Entry - p. 173 43. Target Cells and Substances - p. 177 44. Pathways of Spread - p. 179 45. Defense Mechanisms - p. 184 46. Genetic Resistance of Animals to Infectious Diseases - p. 188 47. Bacterial Diseases - p. 189 48. Viral Diseases - p. 237 49. Morphology of Viruses - p. 237 50. Target Cells - p. 237 51. Viral Pathogenicity and Replication Cycle - p. 238 52. Virulence Factors - p. 240 53. Mechanisms of Genomic Change - p. 241 54. Defense Mechanisms - p. 243 55. Viral Diseases of Organ Systems - p. 243 56. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal Cavity - p. 243 57. Hepatobiliary System and Exocrine Pancreas - p. 251 58. Respiratory System, Thoracic Cavities, Mediastinum, and Pleurae - p. 252 59. Cardiovascular System and Lymphatic Vessels - p. 258 60. Bone Marrow, Blood Cells, and Lymphoid/Lymphatic System - p. 264 61. Nervous System - p. 268 62. Bone, Joints, Ligaments, and Tendons - p. 274 63. Integumentary System - p. 274 64. Female Reproductive System and Mammae - p. 277 65. Male Reproductive System - p. 279 66. The Eye - p. 279 67. Fungal Diseases (Mycoses) - p. 279 68. Protozoan Diseases - p. 287 69. Prion Diseases (Spongiform Encephalopathies) - p. 292 70. Chapter 5. Diseases of Immunitya - p. 295 71. General Features of the Immune System - p. 295 72. Innate Immunity (Nonspecific Immunity) - p. 295 73. Adaptive Immunity (Specific Immunity) - p. 299 74. Disorders of the Immune System - p. 313 75. Chapter 6. Neoplasia and Tumor Biologya - p. 341 76. Introduction - p. 341 77. General Nomenclature - p. 341 78. Tumor Characteristics (Essential Concept 6.1) - p. 345 79. Neoplastic Transformation (Essential Concept 6.2) - p. 352 80. Tumor Microenvironment (Essential Concept 6.3) - p. 354 81. Tumor Immunity (see Essential Concept 6.3) - p. 358 82. Tumor Dissemination (Essential Concept 6.4) - p. 362 83. Systemic Clinical Effects on the Animal (see Essential Concept 6.3) - p. 366 84. Heritable Alterations in Cancer (Essential Concept 6.5) - p. 368 85. Molecular Determinants of Cancer - p. 371 86. Mechanisms of Carcinogenesis - p. 375 87. Cancer in Animals - p. 376 88. Section II. Pathology of Organ Systems - p. P2 89. Introduction - p. 395 90. Chapter 7. Alimentary System and the Peritoneum, Omentum, Mesentery, and Peritoneal CavityA detailed medical diagram showing A kidney filtering unit with blood vessels, filtering membrane, and small structural parts involved in urine formation.The image shows a detailed cross section drawing of A kidney filtering unit called a glomerulus inside a round capsule. At the top there is a blood vessel entering and another leaving, forming a small knot of capillary loops. Red blood cells are visible inside these tiny blood vessels. The capillary walls appear thin and are surrounded by supporting cells. Around the capillary loops there is a clear space that represents the area where filtered fluid collects before moving into a small tube at the bottom. The inner lining of the capsule is made of specialized cells with foot like extensions that wrap around the capillaries and help control filtration. A thicker central area contains supporting tissue and cells that hold the capillary loops together. The lower part shows a narrow tube where the filtered fluid flows out to form urine. The drawing uses soft colors to separate blood spaces, supporting cells, and surrounding capsule layers. This diagram explains how blood enters the glomerulus, fluid is filtered through thin walls, and waste fluid passes into the collecting space while blood cells remain inside the vessels.a - p. 396 91. Introduction - p. 396 92. Structureb and Function - p. 396 93. Dysfunction/Responses to Injury - p. 403 94. Portals of Entry/Pathways of Spread - p. 411 95. Defense Mechanisms/Barrier Systems - p. 415 96. Diseases Affecting Multiple Species of Domestic Animalsc,d - p. 417 97. Oral Cavity - p. 417 98. Teeth - p. 423 99. Tonsils - p. 424 100. Salivary Glands - p. 425 101. Tongue - p. 425 102. Esophagus - p. 427 103. Rumen, Reticulum, and Omasum - p. 431 104. Stomach and Abomasum - p. 431 105. Intestine - p. 439 106. Peritoneum, Omentum, Mesentery, and Peritoneal Cavity - p. 459 107. Diseases of Horses - p. 460 108. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 464 109. Diseases of Pigs - p. 475 110. Diseases of Dogs - p. 480 111. Diseases of Cats - p. 484 112. Chapter 8. Hepatobiliary System and Exocrine Pancreasa - p. 486 113. Liver and Intrahepatic Biliary System - p. 486 114. Structureb - p. 486 115. Embryologic Development - p. 491 116. Function - p. 491 117. Dysfunction/Responses to Injury - p. 493 118. Oncotic Necrosis and Apoptosis - p. 493 119. Morphologic Classification of Hepatobiliary Disease - p. 496 120. Disturbances of Bile Flow and Icterus - p. 498 121. Ductular Reaction (Biliary Hyperplasia) - p. 499 122. Regeneration - p. 500 123. Fibrosis - p. 500 124. End-Stage Liver or Cirrhosis - p. 502 125. Hepatic Failure - p. 504 126. Aging - p. 504 127. Portals of Entry/Pathways of Spread - p. 505 128. Defense Mechanisms/Barrier Systems - p. 505 129. Diseases Affecting Multiple Species of Domestic Animals - p. 506 130. Diseases of Horses - p. 527 131. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 529 132. Diseases of Pigs - p. 531 133. Diseases of Dogs - p. 532 134. Diseases of Cats - p. 535 135. Gallbladder and Extrahepatic Bile Ducts - p. 535 136. Exocrine Pancreas - p. 539 137. Chapter 9. Respiratory System, Thoracic Cavities, Mediastinum, and Pleuraea - p. 547 138. Introduction - p. 547 139. Structure and Function - p. 547 140. Dysfunction/Responses to Injury - p. 550 141. Portals of Entry/Pathways of Spread - p. 558 142. Defense Mechanisms/Barrier Systems - p. 558 143. Diseases Affecting Multiple Species of Domestic Animalsb - p. 563 144. Diseases of Horses - p. 598 145. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 606 146. Diseases of Pigs - p. 624 147. Diseases of Dogs - p. 630 148. Diseases of Cats - p. 638 149. Chapter 10. Cardiovascular System, Pericardial Cavity, and Lymphatic Vesselsa - p. 643 150. Structure - p. 643 151. Function - p. 647 152. Dysfunction/Responses to Injury - p. 649 153. Portals of Entry/Pathways of Spread - p. 661 154. Defense Mechanisms/Barrier Systems - p. 662 155. Diseases Affecting Multiple Species of Domestic Animals - p. 662 156. Diseases of Horses - p. 685 157. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 687 158. Diseases of Pigs - p. 688 159. Diseases of Dogs - p. 691 160. Diseases of Cats - p. 697 161. Chapter 11. The Urinary Systema - p. 699 162. Kidneyb - p. 699 163. Lower Urinary Tracte - p. 756 164. Chapter 12. Endocrine Systema - p. 767 165. Structure and Function - p. 767 166. Dysfunction/Responses to Injury - p. 777 167. Portals of Entry/Pathways of Spread - p. 779 168. Defense Mechanisms/Barrier Systems - p. 779 169. Diseases Affecting Multiple Species of Domestic Animalse - p. 780 170. Diseases of Horses - p. 799 171. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 800 172. Diseases of Pigs - p. 801 173. Diseases of Dogs - p. 801 174. Diseases of Cats - p. 805 175. Chapter13. Bone Marrow, Blood Cells, and the Lymphoid/Lymphatic Systema - p. 809 176. Chapter 14. Nervous Systema - p. 892 177. The Nervous System - p. 892 178. Central Nervous System - p. 893 179. Peripheral Nervous System - p. 983 180. Chapter 15. Skeletal Musclea - p. 992 181. Structure - p. 992 182. Function - p. 993 183. Dysfunction/Responses to Injury - p. 997 184. Defense Mechanisms/Barrier Systems - p. 1007 185. Diseases Affecting Multiple Species of Domestic Animals - p. 1007 186. Diseases of Horses - p. 1016 187. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1024 188. Diseases of Pigs - p. 1028 189. Diseases of Dogs - p. 1029 190. Diseases of Cats - p. 1035 191. Chapter 16. Bones, Joints, Tendons, and Ligamentsa - p. 1037 192. Introduction - p. 1037 193. Structure and Function - p. 1037 194. Dysfunction/Responses to Injury - p. 1048 195. Portals of Entry/Pathways of Spread - p. 1055 196. Defense Mechanisms/Barrier Systems - p. 1056 197. Diseases Affecting Multiple Species of Domestic Animalsf - p. 1056 198. Diseases of Horses - p. 1091 199. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1091 200. Diseases of Pigs - p. 1091 201. Diseases of Dogs - p. 1091 202. Diseases of Cats - p. 1094 203. Chapter17. The Integumenta - p. 1095 204. Structure - p. 1095 205. Function - p. 1107 206. Dysfunction/Responses to Injury - p. 1108 207. Types of Clinical Skin Lesions - p. 1108 208. Diagnostic Procedures: Clinical Skin Lesions - p. 1122 209. Skin Biopsy Procedure - p. 1122 210. Patient Selection for Biopsy - p. 1122 211. Selection of Skin Lesions for Biopsy - p. 1123 212. Selection of Biopsy Site Based on the Type of Skin Lesion - p. 1123 213. Skin Biopsy Techniques - p. 1126 214. Artifacts - p. 1127 215. Skin Preparation - p. 1127 216. Tissue Fixation - p. 1127 217. History - p. 1127 218. Ancillary Procedures - p. 1127 219. Types (Patterns) of Histopathologic Skin Lesions - p. 1127 220. Regeneration and Repair - p. 1146 221. Portals of Entry/Pathways of Spread - p. 1146 222. Defense Mechanisms/Barrier Systems - p. 1148 223. Diseases Affecting Multiple Species of Domestic Animalsg - p. 1149 224. Congenital and Inherited Disorders - p. 1149 225. Disorders of Radiation, Chemical, or Physical Injury - p. 1154 226. Microbial and Parasitic Disorders - p. 1162 227. Viral Infections - p. 1162 228. Bacterial Infections - p. 1166 229. Fungal (Mycotic) Infections - p. 1173 230. Algal Infections - p. 1178 231. Parasitic Infections - p. 1178 232. Diseases of Horses - p. 1219 233. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1223 234. Diseases of Pigs - p. 1229 235. Diseases of Dogs - p. 1233 236. Diseases of Cats - p. 1256 237. Chapter 18. Female Reproductive System and Mammaea - p. 1263 238. Introduction - p. 1263 239. Structureb - p. 1263 240. Function - p. 1265 241. Dysfunction/Responses to Injury - p. 1266 242. Portals of Entry/Pathways of Spread - p. 1267 243. Defense Mechanisms/Barrier Systems - p. 1267 244. Diseases Affecting Multiple Species of Domestic Animals - p. 1270 245. Diseases of Horses - p. 1290 246. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1293 247. Diseases of Pigs - p. 1302 248. Diseases of Dogs - p. 1303 249. Diseases of Cats - p. 1307 250. Chapter 19. Male Reproductive Systema - p. 1308 251. Chapter 20. The Eara - p. 1336 252. Chapter 21. The Eyea - p. 1379 253. Introduction - p. 1379 254. Structure and Function - p. 1381 255. Dysfunction/Response to Injury - p. 1387 256. Portals of Entry/Pathways of Spread - p. 1397 257. Defense Mechanisms/Barrier Systems - p. 1399 258. Diseases Affecting Multiple Species of Domestic Animalsb - p. 1401 259. Diseases of Horses - p. 1424 260. Diseases of Ruminants (Cattle, Sheep, and Goats) - p. 1426 261. Diseases of Pigs - p. 1427 262. Diseases of Dogs - p. 1427 263. Diseases of Cats - p. 1431 264. Section III: Appendices, Veterinary Diagnostic Pathology - p. rP1 265. Introduction∗ - p. 1435 266. Appendix A. Communication, Collaboration, and Consultation in Veterinary Pathology - p. e1 267. Appendix B. Photographic Techniques in Veterinary Pathology - p. e15 268. Appendix C. Postmortem Examination (Autopsy) of Domestic Animal Speciesa - p. e23 269. Appendix D. Recognition and Interpretation of Macroscopic (Gross) Lesions - p. e43 270. Appendix E. Diagnoses in Veterinary Pathologya - p. e85 271. Appendix F. General Principles of Tissue Fixation and Processing - p. e87 272. Appendix G. Fixatives and Fixation - p. e94 273. Appendix H. Fixation and Trimming of the Brain, Spinal Cord, and Nerves - p. e98 274. Appendix I. Surgical Biopsies—Procurement, Processing, and Sectioning Artifactsa - p. e104 275. Appendix J. Gross Examination and Infusion Fixation of the Lung - p. e105 276. Appendix K. Necropsy Techniques by Organ Systema - p. e109 277. Index - p. 1437
