Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.
Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
1. Pathophysiological Aspects of Proteases in Cancer - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Dedication - p. Page iv 7. Contributors - p. Page v 8. Preface - p. Page ix 9. List of Illustrations - p. Page xi 10. List of Tables - p. Page xii 11. Chapter 1 : Pathophysiological aspects of calpains in cancer - p. Page xii 12. Chapter 2 : Mitochondrial proteases in cancer development and progression - p. Page 21 13. Chapter 3 : Proteases in head and neck cancer - p. Page 41 14. Chapter 4 : Matrix metalloproteinases and uveal melanoma - p. Page 64 15. Chapter 5 : Proteases in DNA damage, repair, and radioresistance: Cellular and molecular aspects - p. Page 85 16. Chapter 6 : Radiotherapy, proteases and gastric cancer: A complex interplay - p. Page 100 17. Chapter 7 : Matrix metalloproteases in the pathogenesis of hepatocarcinoma - p. Page 114 18. Chapter 8 : Exploring synthetic and natural compounds for cathepsin B: Mechanisms and therapy - p. Page 130 19. Chapter 9 : Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer - p. Page 146 20. Chapter 10 : Ubiquitin specific protease 3,7 in bone cancer and squamous cell carcinoma - p. Page 155 21. Chapter 11 : Serine protease: Structure, classification, mechanism and role in breast cancer - p. Page 169 22. Chapter 12 : Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and a novel therapeutic targets for gastric cancer - p. Page 183 23. Chapter 13 : Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer - p. Page 199 24. Chapter 14 : From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis - p. Page 218 25. Chapter 15 : Cathepsins as diagnostic and prognostic markers in oral cancer - p. Page 236 26. Chapter 16 : Role of kallikreins in prostate cancer - p. Page 250 27. Chapter 17 : Mechanistic aspects of serine protease as biomarkers in wound healing of lung cancer - p. Page 266 28. Chapter 18 : The role of acetylcholinesterase in cancer development and possible therapeutic applications - p. Page 281 29. Chapter 19 : Therapeutics of animal-derived compounds in proteases-induced cancer - p. Page 301 30. Chapter 20 : Molecular warriors: Proteases as sentinels in the war against cancer diagnosis and prognosis - p. Page 322 31. Chapter 21 : Serine proteases and their contribution to chemoresistance in cancer - p. Page 340 32. Chapter 22 : Cathepsins, chemoresistance, and cancer - p. Page 360 33. Chapter 23 : Matrix metalloproteinases, chemoresistance and cancer - p. Page 381 34. Chapter 24 : MMPs (-2 and -9)-mediated drug resistance and their reversal in gynecological cancer - p. Page 401 35. Chapter 25 : The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer - p. Page 419 36. Chapter 26 : Role of proteasome in the development of chemoresistance in multiple myeloma - p. Page 433 37. Chapter 27 : Role of cysteine cathepsin and matrix metalloproteinases in progression and chemoresistance in ovarian and breast cancer - p. Page 448 38. Chapter 28 : Proteases, chemoresistance, and cancer - p. Page 466 39. Chapter 29 : Breaking barriers: Proteases as key players in cancer chemoresistance - p. Page 480 40. Chapter 30 : Matrix metalloproteases–targeting low-molecular-weight compounds - p. Page 497 41. Chapter 31 : Evidence from clinical trials on synthetic protease inhibitors in oral, head, and neck cancer - p. Page 514 42. Chapter 32 : Synthetic protease inhibitors in endocrine and gastroenterology cancers: Results of clinical trials - p. Page 531 43. Chapter 33 : Side effects of synthetic protease inhibitors used in gynecology cancers - p. Page 548 44. Chapter 34 : The role of synthetic protease inhibitors in breast cancer - p. Page 569 45. Chapter 35 : Cathepsin-responsive nanomaterials for targeted delivery of malignant tumors - p. Page 583 46. Index - p. Page 598
Pathophysiological Aspects of Proteases in Cancer provides a comprehensive overview of the multifaceted field of proteases in the cellular environment and focuses on the recently elucidated functions of complex proteolytic systems in physiology and pathophysiology. The book both gives insights on the general aspects of the role of proteases in cancer, their role as diagnostics and prognostics biomarkers, their impact on chemoresistance, and the future cutting-edge technologies like cocktail therapies and Cyber Knife technology. Given the breadth and depth of information covered in the respective contributions, the book will be immensely useful for researchers in oncology and working to identify targets for drug development.
Multidisciplinary in scope, the book bridges the gap between fundamental and translational research, with applications in the biomedical and pharmaceutical industry, making it a thought-provoking read for basic and applied scientists engaged in biomedical research.
1. Pathophysiological Aspects of Proteases in Cancer - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Dedication - p. Page iv 7. Contributors - p. Page v 8. Preface - p. Page ix 9. List of Illustrations - p. Page xi 10. List of Tables - p. Page xii 11. Chapter 1 : Pathophysiological aspects of calpains in cancer - p. Page xii 12. Chapter 2 : Mitochondrial proteases in cancer development and progression - p. Page 21 13. Chapter 3 : Proteases in head and neck cancer - p. Page 41 14. Chapter 4 : Matrix metalloproteinases and uveal melanoma - p. Page 64 15. Chapter 5 : Proteases in DNA damage, repair, and radioresistance: Cellular and molecular aspects - p. Page 85 16. Chapter 6 : Radiotherapy, proteases and gastric cancer: A complex interplay - p. Page 100 17. Chapter 7 : Matrix metalloproteases in the pathogenesis of hepatocarcinoma - p. Page 114 18. Chapter 8 : Exploring synthetic and natural compounds for cathepsin B: Mechanisms and therapy - p. Page 130 19. Chapter 9 : Kallikrein-related peptidase 3 (KLK3) as valuable biomarkers for prostate cancer - p. Page 146 20. Chapter 10 : Ubiquitin specific protease 3,7 in bone cancer and squamous cell carcinoma - p. Page 155 21. Chapter 11 : Serine protease: Structure, classification, mechanism and role in breast cancer - p. Page 169 22. Chapter 12 : Protease activator receptor-1 and matrix metalloproteinase-1 as prognostic factors and a novel therapeutic targets for gastric cancer - p. Page 183 23. Chapter 13 : Matrix metalloproteases as diagnostic and prognostic biomarkers in cancer - p. Page 199 24. Chapter 14 : From enzyme to predictors: Serine proteases in cancer diagnosis and prognosis - p. Page 218 25. Chapter 15 : Cathepsins as diagnostic and prognostic markers in oral cancer - p. Page 236 26. Chapter 16 : Role of kallikreins in prostate cancer - p. Page 250 27. Chapter 17 : Mechanistic aspects of serine protease as biomarkers in wound healing of lung cancer - p. Page 266 28. Chapter 18 : The role of acetylcholinesterase in cancer development and possible therapeutic applications - p. Page 281 29. Chapter 19 : Therapeutics of animal-derived compounds in proteases-induced cancer - p. Page 301 30. Chapter 20 : Molecular warriors: Proteases as sentinels in the war against cancer diagnosis and prognosis - p. Page 322 31. Chapter 21 : Serine proteases and their contribution to chemoresistance in cancer - p. Page 340 32. Chapter 22 : Cathepsins, chemoresistance, and cancer - p. Page 360 33. Chapter 23 : Matrix metalloproteinases, chemoresistance and cancer - p. Page 381 34. Chapter 24 : MMPs (-2 and -9)-mediated drug resistance and their reversal in gynecological cancer - p. Page 401 35. Chapter 25 : The link between trypsinogen and chymotrypsinogen in gastrointestinal cancer - p. Page 419 36. Chapter 26 : Role of proteasome in the development of chemoresistance in multiple myeloma - p. Page 433 37. Chapter 27 : Role of cysteine cathepsin and matrix metalloproteinases in progression and chemoresistance in ovarian and breast cancer - p. Page 448 38. Chapter 28 : Proteases, chemoresistance, and cancer - p. Page 466 39. Chapter 29 : Breaking barriers: Proteases as key players in cancer chemoresistance - p. Page 480 40. Chapter 30 : Matrix metalloproteases–targeting low-molecular-weight compounds - p. Page 497 41. Chapter 31 : Evidence from clinical trials on synthetic protease inhibitors in oral, head, and neck cancer - p. Page 514 42. Chapter 32 : Synthetic protease inhibitors in endocrine and gastroenterology cancers: Results of clinical trials - p. Page 531 43. Chapter 33 : Side effects of synthetic protease inhibitors used in gynecology cancers - p. Page 548 44. Chapter 34 : The role of synthetic protease inhibitors in breast cancer - p. Page 569 45. Chapter 35 : Cathepsin-responsive nanomaterials for targeted delivery of malignant tumors - p. Page 583 46. Index - p. Page 598
