Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
1. Section I: Introduction - p. xvi 2. Chapter 1. Epigenetics of personalized medicine - p. 3 3. Section II: Epigenetic variations among individuals - p. 12 4. Chapter 2. Personalized epigenetics: Analysis and interpretation of DNA methylation variation - p. 15 5. Chapter 3. Differences in histone modifications between individuals - p. 44 6. Chapter 4. Individual noncoding RNA variations: Their role in shaping and maintaining the epigenetic landscape - p. 71 7. Section III: Technologies for personalized epigenetics - p. 103 8. Chapter 5. Epigenetics technologies for personalized medicine - p. 107 9. Chapter 6. Computational methods in epigenetics - p. 121 10. Section IV: Diagnostic and prognostic epigenetic approaches to personalized medicine - p. 144 11. Chapter 7. Epigenetic biomarkers in personalized medicine - p. 148 12. Chapter 8. Forensic epigenetics in the massively parallel sequencing era - p. 206 13. Chapter 9. Epigenetics in personalized toxicity - p. 229 14. Section V: Environmental personalized epigenetics - p. 248 15. Chapter 10. Environmental contaminants and the epigenome - p. 251 16. Chapter 11. Nutriepigenomics: Paving the way for personalized nutrition - p. 280 17. Section VI: Pharmacology and drug development of personalized epigenetics - p. 304 18. Chapter 12. Personalized pharmacoepigenomics - p. 307 19. Chapter 13. Personalized medicine and epigenetic drug development - p. 327 20. Section VII: Personalized epigenetics of obesity and diabetes - p. 340 21. Chapter 14. Understanding interindividual epigenetic variation in obesity and its management - p. 345 22. Chapter 15. Personalized epigenetic management of diabetes - p. 385 23. Section VIII: Personalized epigenetics of cancer - p. 398 24. Chapter 16. Personalized epigenetics of DNA methylation in cancer - p. 407 25. Chapter 17. Histone modification and personalized epigenomics in cancer - p. 429 26. Chapter 18. Epigenetic modification of miRNA in cancer - p. 482 27. Chapter 19. Role of epigenetics in drug-resistance: A personalized approach to cancer therapy - p. 511 28. Section IX: Personalized epigenetics of neurological disorders and diseases - p. 530 29. Chapter 20. Personalized epigenetics and neurological disorders - p. 533 30. Chapter 21. Personalized epigenetics of neurodegenerative diseases - p. 565 31. Section X: Personalized epigenetics of other disorders and diseases - p. 598 32. Chapter 22. Managing autoimmune disorders through personalized epigenetic approaches - p. 601 33. Chapter 23. Advances in personalized epigenetics in infectious diseases - p. 634 34. Chapter 24. Personalized epigenetics of aging - p. 657 35. Section XI: Personalized epigenetics of pain management - p. 691 36. Chapter 25. Epigenetics and personalized pain management - p. 695 37. Section XII: Challenges and future directions - p. 717 38. Chapter 26. Future challenges and prospects for personalized epigenetics - p. 730 39. Index - p. 745
Personalized Epigenetics, Second Edition discusses the core translatability of epigenetics to health management of individuals who have unique variations in their epigenetic signatures that can guide both disorder and disease prevention and therapy. Fully updated and revised, this new edition details inter-individual variability in the major epigenetic process in humans consisting of DNA methylation, histone modifications, noncoding RNA, and the diagnostic, prognostic, and therapeutic potential of the field. It also reviews the impact of the environment on epigenetic variations among individuals and the role of pharmacology and drug development in personalized epigenetics. Most importantly, the text covers personalized epigenetics from a disease-oriented perspective, presenting chapters that provide advances in widespread disorders or diseases, including diabetes, cancer, autoimmune disorders, obesity, cardiovascular diseases, neurological disorders, and pain management.
1. Section I: Introduction - p. xvi 2. Chapter 1. Epigenetics of personalized medicine - p. 3 3. Section II: Epigenetic variations among individuals - p. 12 4. Chapter 2. Personalized epigenetics: Analysis and interpretation of DNA methylation variation - p. 15 5. Chapter 3. Differences in histone modifications between individuals - p. 44 6. Chapter 4. Individual noncoding RNA variations: Their role in shaping and maintaining the epigenetic landscape - p. 71 7. Section III: Technologies for personalized epigenetics - p. 103 8. Chapter 5. Epigenetics technologies for personalized medicine - p. 107 9. Chapter 6. Computational methods in epigenetics - p. 121 10. Section IV: Diagnostic and prognostic epigenetic approaches to personalized medicine - p. 144 11. Chapter 7. Epigenetic biomarkers in personalized medicine - p. 148 12. Chapter 8. Forensic epigenetics in the massively parallel sequencing era - p. 206 13. Chapter 9. Epigenetics in personalized toxicity - p. 229 14. Section V: Environmental personalized epigenetics - p. 248 15. Chapter 10. Environmental contaminants and the epigenome - p. 251 16. Chapter 11. Nutriepigenomics: Paving the way for personalized nutrition - p. 280 17. Section VI: Pharmacology and drug development of personalized epigenetics - p. 304 18. Chapter 12. Personalized pharmacoepigenomics - p. 307 19. Chapter 13. Personalized medicine and epigenetic drug development - p. 327 20. Section VII: Personalized epigenetics of obesity and diabetes - p. 340 21. Chapter 14. Understanding interindividual epigenetic variation in obesity and its management - p. 345 22. Chapter 15. Personalized epigenetic management of diabetes - p. 385 23. Section VIII: Personalized epigenetics of cancer - p. 398 24. Chapter 16. Personalized epigenetics of DNA methylation in cancer - p. 407 25. Chapter 17. Histone modification and personalized epigenomics in cancer - p. 429 26. Chapter 18. Epigenetic modification of miRNA in cancer - p. 482 27. Chapter 19. Role of epigenetics in drug-resistance: A personalized approach to cancer therapy - p. 511 28. Section IX: Personalized epigenetics of neurological disorders and diseases - p. 530 29. Chapter 20. Personalized epigenetics and neurological disorders - p. 533 30. Chapter 21. Personalized epigenetics of neurodegenerative diseases - p. 565 31. Section X: Personalized epigenetics of other disorders and diseases - p. 598 32. Chapter 22. Managing autoimmune disorders through personalized epigenetic approaches - p. 601 33. Chapter 23. Advances in personalized epigenetics in infectious diseases - p. 634 34. Chapter 24. Personalized epigenetics of aging - p. 657 35. Section XI: Personalized epigenetics of pain management - p. 691 36. Chapter 25. Epigenetics and personalized pain management - p. 695 37. Section XII: Challenges and future directions - p. 717 38. Chapter 26. Future challenges and prospects for personalized epigenetics - p. 730 39. Index - p. 745
