Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.
A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Dedication - p. Cover 6. List of Contributors - p. Cover 7. Preface - p. Cover 8. Chapter 1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications - p. Cover 9. Chapter 2. Translating Pharmacogenomic Research to Therapeutic Potentials - p. 32 10. Chapter 3. Governmental and Academic Efforts to Advance the Field of Pharmacogenomics - p. 59 11. Chapter 4. Pharmacogenomics in Cancer Therapeutics - p. 88 12. Chapter 4A. A Look to the Future: Cancer Epigenetics - p. 116 13. Chapter 5. Pharmacogenetics in Cardiovascular Diseases - p. 131 14. Chapter 5A. A Look to the Future: Cardiovascular Pharmacoepigenetics - p. 172 15. Chapter 6. Pharmacogenomics in Psychiatric Disorders - p. 187 16. Chapter 6A. A Look to the Future: Epigenetics in Psychiatric Disorders and Treatment - p. 215 17. Chapter 7. The Role of Pharmacogenomics in Diabetes, HIV Infection, and Pain Management - p. 239 18. Chapter 8. Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development - p. 265 19. Chapter 8A. Modeling the Pharmacogenetic Architecture of Drug Response - p. 291 20. Chapter 9. Study Designs in Clinical Pharmacogenetic and Pharmacogenomic Research - p. 306 21. Chapter 9A. Incorporating Pharmacogenomics in Drug Development: A Perspective from Industry - p. 338 22. Chapter 10. The Importance of Ethnicity Definitions and Pharmacogenomics in Ethnobridging - p. 362 23. Chapter 11. Beyond ELSIs: Where to from Here? From “Regulating” to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine - p. 396 24. Chapter 12. Pharmacoeconomics of Pharmacogenetics within the Context of General Health Technology Assessments - p. 428 25. Chapter 13. Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics Is Not Enough - p. 450 26. Color Plates - p. 467 27. Index - p. 467
Pharmacogenomics: Challenges and Opportunities in Therapeutic Implementation includes discussions and viewpoints from the academic, regulatory, pharmaceutical, clinical, socio-ethical and economic perspectives. Each chapter presents an overview of the potential or opportunity within the areas discussed and also outlines foreseeable challenges and limitations in moving pharmacogenomics into drug development and direct therapeutic applications. This edited book contains review questions for a more in-depth analysis of the implications of pharmacogenomics and discussion points to generate ideas on best to move the field forward. Clinical pearls and case studies are used to illustrate real-life experiences and both successful and unsuccessful applications. Tables, figures, and annotations are included throughout the book to facilitate understanding and further reference.
A companion website offers an elaboration on key points and discussion questions and provides patient case scenarios that illustrate how pharmacogenomics may be applied to a clinical setting
1. Cover image - p. Cover 2. Title page - p. Cover 3. Table of Contents - p. Cover 4. Copyright - p. Cover 5. Dedication - p. Cover 6. List of Contributors - p. Cover 7. Preface - p. Cover 8. Chapter 1. Principles of Pharmacogenomics: Pharmacokinetic, Pharmacodynamic, and Clinical Implications - p. Cover 9. Chapter 2. Translating Pharmacogenomic Research to Therapeutic Potentials - p. 32 10. Chapter 3. Governmental and Academic Efforts to Advance the Field of Pharmacogenomics - p. 59 11. Chapter 4. Pharmacogenomics in Cancer Therapeutics - p. 88 12. Chapter 4A. A Look to the Future: Cancer Epigenetics - p. 116 13. Chapter 5. Pharmacogenetics in Cardiovascular Diseases - p. 131 14. Chapter 5A. A Look to the Future: Cardiovascular Pharmacoepigenetics - p. 172 15. Chapter 6. Pharmacogenomics in Psychiatric Disorders - p. 187 16. Chapter 6A. A Look to the Future: Epigenetics in Psychiatric Disorders and Treatment - p. 215 17. Chapter 7. The Role of Pharmacogenomics in Diabetes, HIV Infection, and Pain Management - p. 239 18. Chapter 8. Molecular Approaches, Models, and Techniques in Pharmacogenomic Research and Development - p. 265 19. Chapter 8A. Modeling the Pharmacogenetic Architecture of Drug Response - p. 291 20. Chapter 9. Study Designs in Clinical Pharmacogenetic and Pharmacogenomic Research - p. 306 21. Chapter 9A. Incorporating Pharmacogenomics in Drug Development: A Perspective from Industry - p. 338 22. Chapter 10. The Importance of Ethnicity Definitions and Pharmacogenomics in Ethnobridging - p. 362 23. Chapter 11. Beyond ELSIs: Where to from Here? From “Regulating” to Anticipating and Shaping the Innovation Trajectory in Personalized Medicine - p. 396 24. Chapter 12. Pharmacoeconomics of Pharmacogenetics within the Context of General Health Technology Assessments - p. 428 25. Chapter 13. Integrating Genomics into Pharmacy Education and Practice: Pharmacogenomics Is Not Enough - p. 450 26. Color Plates - p. 467 27. Index - p. 467
