Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract.
As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students.
1. 25.2: Introduction - p. 587 2. 25.3: Intrinsic and Extrinsic Elements of the Barrier - p. 588 3. 25.4: The Intestinal Epithelial Barrier and Transcellular and Paracellular Transport - p. 588 4. 25.5: Protein Components of the TJ - p. 594 5. 25.6: Regulation of Intestinal Epithelial TJ Barrier - p. 600 6. 25.7: Clinical Disorders of Intestinal TJ Barrier Defect - p. 617 7. 25.8: Concluding Remarks - p. 622 8. Chapter 26 Gut Barrier: Adaptive Immunity - p. 641 9. Chapter 27 Gut Barrier: Innate Immunity - p. 663 10. Chapter 28 Chemosensing in the Colon - p. 671 11. Chapter 29 Mucosal Restitution and Repair - p. 683 12. Chapter 30 Luminal Chemosensing and Mucosal Defenses in the Upper GI Tract - p. 709 13. Chapter 31 Intestinal Tuft Cells - p. 721 14. Chapter 32 Gastrointestinal Microbial Ecology With Perspectives on Health and Disease - p. 737 15. Chapter 33 Diet Effects on Gut Microbiome Composition, Function, and Host Physiology - p. 755 16. Chapter 34 Influence of the Gut Microbiome on Immune Development During Early Life - p. 767 17. Chapter 35 Gut Microbiome and Metabolism - p. 775 18. Chapter 36 Microbial Physiology of the Digestive Tract and Its Role in Inflammatory Bowel Diseases - p. 795 19. Chapter 37 Salivary Gland Secretion - p. 813 20. Chapter 38 The Cell Biology of Gastric Acid Secretion - p. 831 21. Chapter 39 Structure-Function Relationships in the Pancreatic Acinar Cell - p. 869 22. Chapter 40 Regulation of Pancreatic Secretion - p. 895 23. Chapter 41 Bile Formation and the Enterohepatic Circulation - p. 931 24. Chapter 42 Mechanisms of Hepatocyte Organic Anion Transport - p. 957 25. Chapter 43 Mechanisms of Hepatocyte Detoxification - p. 981 26. Chapter 44 Physiology of Cholngiocytes - p. 1003 27. Chapter 45 Molecular Mechanisms of Polarized Protein Trafficking in Epithelial Cells - p. 1027 28. Chapter 46 Sugar Absorption - p. 1051 29. Chapter 47 Protein Digestion and Absorption - p. 1063 30. Chapter 48 Enterocyte Fatty Acid Handling Proteins and Chylomicron Formation - p. 1087 31. Chapter 49 Genetic Regulation of Intestinal Lipid Transport and Metabolism - p. 1109 32. Chapter 50 Digestion and Intestinal Absorption of Dietary Carotenoids and Vitamin A☆ - p. 1133 33. Chapter 51 The Vitamin D System: Biological and Molecular Actions in the Intestine and Colon - p. 1153 34. Chapter 52 Bioavailability of Vitamin E - p. 1181 35. Chapter 53 Intestinal Absorption of Vitamin K: Cellular and Molecular Mechanisms - p. 1197 36. Chapter 54 Intestinal Absorption of Water-Soluble Vitamins: Cellular and Molecular Mechanisms - p. 1201 37. Chapter 55 Water Transport in the Gastrointestinal Tract - p. 1249 38. Chapter 56 Na+/H+ Exchange in Mammalian Digestive Tract - p. 1273 39. Chapter 57 Intestinal Anion Absorption - p. 1317 40. Chapter 58 Ion Channels of the Gastrointestinal Epithelial Cells - p. 1363 41. Chapter 59 Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium - p. 1405 42. Chapter 60 Mechanisms and Regulation of Intestinal Iron Transport - p. 1451 43. Chapter 61 Trace Metal Absorption and Transport - p. 1485 44. Chapter 62 The Gastrointestinal Tract and Control of Food Intake - p. 1501 45. Chapter 63 Mechanisms of Helicobacter pylori-Induced Gastric Inflammation - p. 1517 46. Chapter 64 Host-Pathogen Interactions in Pathophysiology of Diarrheal Disorders - p. 1547 47. Chapter 65 Recruitment of Inflammatory and Immune Cells in the Gut - p. 1579 48. Chapter 66 Mechanisms of Gastrointestinal Malignancies - p. 1615 49. Chapter 67 Neuropathophysiology of the Irritable Bowel Syndrome - p. 1643 50. Chapter 68 Pathophysiology of Diarrhea and Its Clinical Implications - p. 1669 51. Index - p. I1
Physiology of the Gastrointestinal Tract, Sixth Edition, a Two-Volume set, covers the study of the mechanical, physical and biochemical functions of the GI Tract by linking clinical disease and disorder, thus bridging the gap between clinical and laboratory medicine while also covering breakthroughs in gastroenterology, such as the brain-gut axis and microbiome. Additionally, information is provided at the organism level, including animal models of gastrointestinal disorders and therapeutic possibilities. The book covers a wide range of conditions, from food allergies, constipation, chronic liver disease and IBS, also exploring emerging techniques to diagnose and normalize functions of the GI tract.
As a highly referenced book, this is a useful resource for gastroenterologists, physiologists, internists, professional researchers and instructors teaching courses for clinical and research students.
1. 25.2: Introduction - p. 587 2. 25.3: Intrinsic and Extrinsic Elements of the Barrier - p. 588 3. 25.4: The Intestinal Epithelial Barrier and Transcellular and Paracellular Transport - p. 588 4. 25.5: Protein Components of the TJ - p. 594 5. 25.6: Regulation of Intestinal Epithelial TJ Barrier - p. 600 6. 25.7: Clinical Disorders of Intestinal TJ Barrier Defect - p. 617 7. 25.8: Concluding Remarks - p. 622 8. Chapter 26 Gut Barrier: Adaptive Immunity - p. 641 9. Chapter 27 Gut Barrier: Innate Immunity - p. 663 10. Chapter 28 Chemosensing in the Colon - p. 671 11. Chapter 29 Mucosal Restitution and Repair - p. 683 12. Chapter 30 Luminal Chemosensing and Mucosal Defenses in the Upper GI Tract - p. 709 13. Chapter 31 Intestinal Tuft Cells - p. 721 14. Chapter 32 Gastrointestinal Microbial Ecology With Perspectives on Health and Disease - p. 737 15. Chapter 33 Diet Effects on Gut Microbiome Composition, Function, and Host Physiology - p. 755 16. Chapter 34 Influence of the Gut Microbiome on Immune Development During Early Life - p. 767 17. Chapter 35 Gut Microbiome and Metabolism - p. 775 18. Chapter 36 Microbial Physiology of the Digestive Tract and Its Role in Inflammatory Bowel Diseases - p. 795 19. Chapter 37 Salivary Gland Secretion - p. 813 20. Chapter 38 The Cell Biology of Gastric Acid Secretion - p. 831 21. Chapter 39 Structure-Function Relationships in the Pancreatic Acinar Cell - p. 869 22. Chapter 40 Regulation of Pancreatic Secretion - p. 895 23. Chapter 41 Bile Formation and the Enterohepatic Circulation - p. 931 24. Chapter 42 Mechanisms of Hepatocyte Organic Anion Transport - p. 957 25. Chapter 43 Mechanisms of Hepatocyte Detoxification - p. 981 26. Chapter 44 Physiology of Cholngiocytes - p. 1003 27. Chapter 45 Molecular Mechanisms of Polarized Protein Trafficking in Epithelial Cells - p. 1027 28. Chapter 46 Sugar Absorption - p. 1051 29. Chapter 47 Protein Digestion and Absorption - p. 1063 30. Chapter 48 Enterocyte Fatty Acid Handling Proteins and Chylomicron Formation - p. 1087 31. Chapter 49 Genetic Regulation of Intestinal Lipid Transport and Metabolism - p. 1109 32. Chapter 50 Digestion and Intestinal Absorption of Dietary Carotenoids and Vitamin A☆ - p. 1133 33. Chapter 51 The Vitamin D System: Biological and Molecular Actions in the Intestine and Colon - p. 1153 34. Chapter 52 Bioavailability of Vitamin E - p. 1181 35. Chapter 53 Intestinal Absorption of Vitamin K: Cellular and Molecular Mechanisms - p. 1197 36. Chapter 54 Intestinal Absorption of Water-Soluble Vitamins: Cellular and Molecular Mechanisms - p. 1201 37. Chapter 55 Water Transport in the Gastrointestinal Tract - p. 1249 38. Chapter 56 Na+/H+ Exchange in Mammalian Digestive Tract - p. 1273 39. Chapter 57 Intestinal Anion Absorption - p. 1317 40. Chapter 58 Ion Channels of the Gastrointestinal Epithelial Cells - p. 1363 41. Chapter 59 Molecular Mechanisms of Intestinal Transport of Calcium, Phosphate, and Magnesium - p. 1405 42. Chapter 60 Mechanisms and Regulation of Intestinal Iron Transport - p. 1451 43. Chapter 61 Trace Metal Absorption and Transport - p. 1485 44. Chapter 62 The Gastrointestinal Tract and Control of Food Intake - p. 1501 45. Chapter 63 Mechanisms of Helicobacter pylori-Induced Gastric Inflammation - p. 1517 46. Chapter 64 Host-Pathogen Interactions in Pathophysiology of Diarrheal Disorders - p. 1547 47. Chapter 65 Recruitment of Inflammatory and Immune Cells in the Gut - p. 1579 48. Chapter 66 Mechanisms of Gastrointestinal Malignancies - p. 1615 49. Chapter 67 Neuropathophysiology of the Irritable Bowel Syndrome - p. 1643 50. Chapter 68 Pathophysiology of Diarrhea and Its Clinical Implications - p. 1669 51. Index - p. I1
