Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery is a comprehensive guide to PLGA nanoparticles for targeting various diseases, covering principles, formation, characterization, applications, regulations and the latest advances. Sections introduce the fundamental aspects of PLGA nanoparticles for drug delivery, including properties, preparation methods, characterization, drug loading methods, and drug release mechanisms, along with a focus on applications. Application of PLGA nanoparticles for the treatment of cancer, inflammatory, cerebral, cardiovascular, and infectious diseases, as well as in regenerative medicine, photodynamic and photothermal therapy, and gene therapy, are all explained in detail.
The final chapters explore recent advances and regulatory aspects. This book is a valuable resource for researchers and advanced students across nanomedicine, polymer science, bio-based materials, chemistry, biomedicine, biotechnology, and materials engineering, as well as for industrial scientists and R&D professionals with an interest in nanoparticles for drug delivery, pharmaceutical formulations and regulations, and development of innovative biodegradable materials.
1. Chapter 1 : History, introduction, and properties of PLGA as a drug delivery carrier - p. Page xi 2. Chapter 2 : Preparation and characterization of PLGA nanoparticles - p. Page 19 3. Chapter 3 : Drug loading methods and drug release mechanisms of PLGA nanoparticles - p. Page 49 4. Chapter 4 : Biofate and cellular interactions of PLGA nanoparticles - p. Page 81 5. Chapter 5 : Targeting strategies using PLGA nanoparticles for efficient drug delivery - p. Page 110 6. Chapter 6 : Current progress in PLGA-based nanoparticles for treatment of cancer diseases - p. Page 145 7. Chapter 7 : PLGA-based nanoparticles for enhanced diagnosis and cancer therapy - p. Page 171 8. Chapter 8 : PLGA-based nanoparticles for the treatment of inflammatory diseases - p. Page 203 9. Chapter 9 : PLGA-based nanoparticles for treatment of cerebral diseases - p. Page 227 10. Chapter 10 : PLGA nanoparticles for treatment of cardiovascular diseases - p. Page 262 11. Chapter 11 : PLGA-based nanoparticles for treatment of infectious diseases - p. Page 296 12. Chapter 12 : PLGA-based nanoparticles as regenerative medicine - p. Page 326 13. Chapter 13 : Photodynamic and photothermal therapy using PLGA nanoparticles - p. Page 351 14. Chapter 14 : Gene therapy using PLGA nanoparticles - p. Page 382 15. Chapter 15 : Hybrid PLGA nanoparticles as advanced drug delivery and theranostic applications - p. Page 408 16. Chapter 16 : Clinical translation of PLGA nanoparticles into market—From benchside to breakthrough therapy - p. Page 427 17. Chapter 17 : Biological toxicity and environmental hazards associated with PLGA nanoparticles - p. Page 453 18. Chapter 18 : PLGA nanoparticles: Current uses and emerging trends - p. Page 468 19. Index - p. Page 501
Poly(lactic-co-glycolic acid) (PLGA) Nanoparticles for Drug Delivery is a comprehensive guide to PLGA nanoparticles for targeting various diseases, covering principles, formation, characterization, applications, regulations and the latest advances. Sections introduce the fundamental aspects of PLGA nanoparticles for drug delivery, including properties, preparation methods, characterization, drug loading methods, and drug release mechanisms, along with a focus on applications. Application of PLGA nanoparticles for the treatment of cancer, inflammatory, cerebral, cardiovascular, and infectious diseases, as well as in regenerative medicine, photodynamic and photothermal therapy, and gene therapy, are all explained in detail.
The final chapters explore recent advances and regulatory aspects. This book is a valuable resource for researchers and advanced students across nanomedicine, polymer science, bio-based materials, chemistry, biomedicine, biotechnology, and materials engineering, as well as for industrial scientists and R&D professionals with an interest in nanoparticles for drug delivery, pharmaceutical formulations and regulations, and development of innovative biodegradable materials.
1. Chapter 1 : History, introduction, and properties of PLGA as a drug delivery carrier - p. Page xi 2. Chapter 2 : Preparation and characterization of PLGA nanoparticles - p. Page 19 3. Chapter 3 : Drug loading methods and drug release mechanisms of PLGA nanoparticles - p. Page 49 4. Chapter 4 : Biofate and cellular interactions of PLGA nanoparticles - p. Page 81 5. Chapter 5 : Targeting strategies using PLGA nanoparticles for efficient drug delivery - p. Page 110 6. Chapter 6 : Current progress in PLGA-based nanoparticles for treatment of cancer diseases - p. Page 145 7. Chapter 7 : PLGA-based nanoparticles for enhanced diagnosis and cancer therapy - p. Page 171 8. Chapter 8 : PLGA-based nanoparticles for the treatment of inflammatory diseases - p. Page 203 9. Chapter 9 : PLGA-based nanoparticles for treatment of cerebral diseases - p. Page 227 10. Chapter 10 : PLGA nanoparticles for treatment of cardiovascular diseases - p. Page 262 11. Chapter 11 : PLGA-based nanoparticles for treatment of infectious diseases - p. Page 296 12. Chapter 12 : PLGA-based nanoparticles as regenerative medicine - p. Page 326 13. Chapter 13 : Photodynamic and photothermal therapy using PLGA nanoparticles - p. Page 351 14. Chapter 14 : Gene therapy using PLGA nanoparticles - p. Page 382 15. Chapter 15 : Hybrid PLGA nanoparticles as advanced drug delivery and theranostic applications - p. Page 408 16. Chapter 16 : Clinical translation of PLGA nanoparticles into market—From benchside to breakthrough therapy - p. Page 427 17. Chapter 17 : Biological toxicity and environmental hazards associated with PLGA nanoparticles - p. Page 453 18. Chapter 18 : PLGA nanoparticles: Current uses and emerging trends - p. Page 468 19. Index - p. Page 501
