Polyphenols: Mechanisms of Action in Human Health and Disease, Second Edition describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. Chapters highlight the anti-inflammatory activity of polyphenols on key dendritic cells, how they modulate and suppress inflammation, and how they are inactivated or activated by metabolism in the gut and circulating blood. Polyphenols have proven effective for key health benefits, including bone health, organ health, cardiac and vascular conditions, absorption and metabolism, and cancer and diseases of the immune system. They are a unique group of phytochemicals that are present in all fruits, vegetables and other plant products.
This very diverse and multi-functional group of active plant compounds contain powerful antioxidant properties and exhibit remarkable chemical, biological and physiological properties, including cancer prevention and cardio-protective activities.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Preface - p. xv 7. Acknowledgments - p. xvii 8. Section I: Overview of Polyphenols and Health - p. xvii 9. Chapter 1: Polyphenols in the Prevention of Acute Pancreatitis in Preclinical Systems of Study: A Revisit - p. xvii 10. Chapter 2: Polyphenols as Supplements in Foods and Beverages: Recent Discoveries and Health Benefits, an Update - p. 9 11. Chapter 3: Xanthohumol and the Medicinal Benefits of Beer - p. 18 12. Chapter 4: Polyphenolic Flavonoids and Metalloprotease Inhibition: Applications to Health and Disease - p. 32 13. Chapter 5: Biological and Pharmacological Effects of Polyphenolic Compounds From Ecklonia cava - p. 40 14. Chapter 6: Clerodendrum volubile: Phenolics and Applications to Health - p. 52 15. Chapter 7: Eryngium campestre L.: Polyphenolic and Flavonoid Compounds; Applications to Health and Disease - p. 67 16. Chapter 8: Antioxidant Activity of Anthocyanins in Common Legume Grains - p. 79 17. Chapter 9: Tomato Polyphenolics: Putative Applications to Health and Disease - p. 92 18. Chapter 10: Polyphenolic Compounds in Sweet Cherries: A Focus on Anthocyanins - p. 102 19. Chapter 11: Citrus Fruit Polyphenols and Flavonoids: Applications to Psychiatric Disorders - p. 118 20. Section II: Polyphenols In Therapy of Obesity and Diabetes - p. 131 21. Chapter 12: Anthocyanins and Diabetes Regulation - p. 131 22. Chapter 13: The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress - p. 145 23. Chapter 14: Role of Protocatechuic Acid in Obesity-Related Pathologies: An Update - p. 179 24. Chapter 15: Exposure to Polyphenolic Compounds Modulates Type 1 Diabetes: The Case of Genistein - p. 192 25. Section III: Mechanisms of Polyphenols Antioxidant Effects - p. 203 26. Chapter 16: Chocolate/Cocoa Polyphenols and Oxidative Stress - p. 203 27. Chapter 17: An Overview of Dietary Polyphenols and Their Therapeutic Effects - p. 219 28. Chapter 18: The Polyphenolic Compound Resveratrol Attenuates Pain: Neurophysiological Mechanisms - p. 235 29. Chapter 19: Possible Benefits and Risks of Polyphenols Supplementation During Pregnancy - p. 247 30. Chapter 20: Flavonoids as Modulators of Neutrophils' Oxidative Burst: Structure-Activity Relationship - p. 260 31. Chapter 21: Manipulation of Mitochondrial Function by Polyphenols for New Treatment Strategies - p. 276 32. Section IV: Bioavailability and Effects On Metabolism - p. 292 33. Chapter 22: Bioavailability of Flavonoids: The Role of Cell Membrane Transporters - p. 292 34. Chapter 23: Interaction of Polyphenols With the Intestinal and Placental Absorption of Some Bioactive Compounds - p. 320 35. Chapter 24: Analyzing Ingredients in Dietary Supplements and Their Metabolites - p. 336 36. Chapter 25: Metabolism of Dietary Polyphenols by Human Gut Microbiota and Their Health Benefits - p. 346 37. Chapter 26: Bioavailability and Biochemistry of Quercetin and Applications to Health and Diseases - p. 359 38. Chapter 27: Effects of Quercetin and Its Combinations on Health - p. 371 39. Section V: Polyphenols In Disease - p. 394 40. Chapter 28: Green Tea Polyphenols in the Amelioration of Osteoarthritis: Memoir on the Preclinical Observations - p. 394 41. Chapter 29: Polyphenolics Evoke Healing Responses: Clinical Evidence and Role of Predictive Biomarkers - p. 402 42. Chapter 30: Hepatoprotective Effects of Green Tea and Its Polyphenols: A Revisit - p. 413 43. Chapter 31: CAPE and Tympanosclerosis - p. 420 44. Chapter 32: The Polyphenolic Compound Hesperidin and Bone Protection - p. 430 45. Index - p. 441
Polyphenols: Mechanisms of Action in Human Health and Disease, Second Edition describes the mechanisms of polyphenol antioxidant activities and their use in disease prevention. Chapters highlight the anti-inflammatory activity of polyphenols on key dendritic cells, how they modulate and suppress inflammation, and how they are inactivated or activated by metabolism in the gut and circulating blood. Polyphenols have proven effective for key health benefits, including bone health, organ health, cardiac and vascular conditions, absorption and metabolism, and cancer and diseases of the immune system. They are a unique group of phytochemicals that are present in all fruits, vegetables and other plant products.
This very diverse and multi-functional group of active plant compounds contain powerful antioxidant properties and exhibit remarkable chemical, biological and physiological properties, including cancer prevention and cardio-protective activities.
1. Cover image - p. iv 2. Title page - p. iv 3. Table of Contents - p. iv 4. Copyright - p. iv 5. Contributors - p. xi 6. Preface - p. xv 7. Acknowledgments - p. xvii 8. Section I: Overview of Polyphenols and Health - p. xvii 9. Chapter 1: Polyphenols in the Prevention of Acute Pancreatitis in Preclinical Systems of Study: A Revisit - p. xvii 10. Chapter 2: Polyphenols as Supplements in Foods and Beverages: Recent Discoveries and Health Benefits, an Update - p. 9 11. Chapter 3: Xanthohumol and the Medicinal Benefits of Beer - p. 18 12. Chapter 4: Polyphenolic Flavonoids and Metalloprotease Inhibition: Applications to Health and Disease - p. 32 13. Chapter 5: Biological and Pharmacological Effects of Polyphenolic Compounds From Ecklonia cava - p. 40 14. Chapter 6: Clerodendrum volubile: Phenolics and Applications to Health - p. 52 15. Chapter 7: Eryngium campestre L.: Polyphenolic and Flavonoid Compounds; Applications to Health and Disease - p. 67 16. Chapter 8: Antioxidant Activity of Anthocyanins in Common Legume Grains - p. 79 17. Chapter 9: Tomato Polyphenolics: Putative Applications to Health and Disease - p. 92 18. Chapter 10: Polyphenolic Compounds in Sweet Cherries: A Focus on Anthocyanins - p. 102 19. Chapter 11: Citrus Fruit Polyphenols and Flavonoids: Applications to Psychiatric Disorders - p. 118 20. Section II: Polyphenols In Therapy of Obesity and Diabetes - p. 131 21. Chapter 12: Anthocyanins and Diabetes Regulation - p. 131 22. Chapter 13: The Role of Direct and Indirect Polyphenolic Antioxidants in Protection Against Oxidative Stress - p. 145 23. Chapter 14: Role of Protocatechuic Acid in Obesity-Related Pathologies: An Update - p. 179 24. Chapter 15: Exposure to Polyphenolic Compounds Modulates Type 1 Diabetes: The Case of Genistein - p. 192 25. Section III: Mechanisms of Polyphenols Antioxidant Effects - p. 203 26. Chapter 16: Chocolate/Cocoa Polyphenols and Oxidative Stress - p. 203 27. Chapter 17: An Overview of Dietary Polyphenols and Their Therapeutic Effects - p. 219 28. Chapter 18: The Polyphenolic Compound Resveratrol Attenuates Pain: Neurophysiological Mechanisms - p. 235 29. Chapter 19: Possible Benefits and Risks of Polyphenols Supplementation During Pregnancy - p. 247 30. Chapter 20: Flavonoids as Modulators of Neutrophils' Oxidative Burst: Structure-Activity Relationship - p. 260 31. Chapter 21: Manipulation of Mitochondrial Function by Polyphenols for New Treatment Strategies - p. 276 32. Section IV: Bioavailability and Effects On Metabolism - p. 292 33. Chapter 22: Bioavailability of Flavonoids: The Role of Cell Membrane Transporters - p. 292 34. Chapter 23: Interaction of Polyphenols With the Intestinal and Placental Absorption of Some Bioactive Compounds - p. 320 35. Chapter 24: Analyzing Ingredients in Dietary Supplements and Their Metabolites - p. 336 36. Chapter 25: Metabolism of Dietary Polyphenols by Human Gut Microbiota and Their Health Benefits - p. 346 37. Chapter 26: Bioavailability and Biochemistry of Quercetin and Applications to Health and Diseases - p. 359 38. Chapter 27: Effects of Quercetin and Its Combinations on Health - p. 371 39. Section V: Polyphenols In Disease - p. 394 40. Chapter 28: Green Tea Polyphenols in the Amelioration of Osteoarthritis: Memoir on the Preclinical Observations - p. 394 41. Chapter 29: Polyphenolics Evoke Healing Responses: Clinical Evidence and Role of Predictive Biomarkers - p. 402 42. Chapter 30: Hepatoprotective Effects of Green Tea and Its Polyphenols: A Revisit - p. 413 43. Chapter 31: CAPE and Tympanosclerosis - p. 420 44. Chapter 32: The Polyphenolic Compound Hesperidin and Bone Protection - p. 430 45. Index - p. 441
