Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Translational Epigenetics Series - p. iii 6. Copyright - p. iii 7. List of contributors - p. xv 8. A note from the editor - p. xvii 9. Chapter 1. Regulation of gene expression in mammals: an overview - p. 1 10. Chapter 2. Post-transcriptional gene regulation: an overview - p. 33 11. Chapter 3. Methods to study post-transcriptional regulation of gene expression - p. 55 12. Chapter 4. Epigenetic regulation of post-transcriptional machinery - p. 69 13. Chapter 5. Post-transcriptional regulation: a less explored territory in the world of neurodegenerative diseases - p. 89 14. Chapter 6. Role of post-transcriptional gene regulation in hematological malignancies - p. 105 15. Chapter 7. Post-transcriptional gene regulation in solid tumors - p. 119 16. Chapter 8. A comprehensive view of the prostate cancer metastasis and role of androgen receptor splice variants - p. 149 17. Chapter 9. Post-transcriptional gene regulation in Cardiorenal syndrome - p. 167 18. Chapter 10. Noncoding RNAs as modulators of post-transcriptional changes and their role in CVDs - p. 175 19. Chapter 11. microRNAs as critical regulators in heart development and diseases - p. 187 20. Chapter 12. MicroRNA regulation in autoimmune diseases - p. 205 21. Chapter 13. Post-transcriptional regulation of inflammatory disorder - p. 239 22. Chapter 14. Post-transcriptional gene regulation in metabolic syndrome - p. 255 23. Post-transcriptional regulation of HIV-1 gene expression - p. 269 24. Post-transcriptional regulation of gene expression in Entamoeba histolytica - p. 295 25. Post-transcriptional regulation of gene expression in human malaria parasite Plasmodium falciparum - p. 309 26. Chapter 18. Hepcidin-induced degradation of iron exporter ferroportin determines anemia of chronic diseases - p. 329 27. Chapter 19. Post-transcriptional regulation of genes and mitochondrial disorder - p. 343 28. Index - p. 365
Post-transcriptional Gene Regulation in Human Disease, a new volume in the Translational Epigenetics book series, offers a thorough overview and discussion of post-transcriptional genetic control mechanisms and their roles across various pathologies and human developmental outcomes, along with regulatory mechanisms targeted for therapeutic approaches. The book is broadly divided in two parts: early chapters describe the basics of post-transcriptional gene regulation, associated epigenetic mechanisms, the role of RNA binding proteins, the evolution of post-transcriptional gene regulation, and methods to study these mechanisms. The second half of the book includes deeper discussion of post-transcriptional gene regulation across specific diseases and therapeutics targets. Various post-transcriptional events, including alternative splicing and polyadenylation, mRNA stability, and miRNAs and their involvement in the disease progression, are examined in detail.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Translational Epigenetics Series - p. iii 6. Copyright - p. iii 7. List of contributors - p. xv 8. A note from the editor - p. xvii 9. Chapter 1. Regulation of gene expression in mammals: an overview - p. 1 10. Chapter 2. Post-transcriptional gene regulation: an overview - p. 33 11. Chapter 3. Methods to study post-transcriptional regulation of gene expression - p. 55 12. Chapter 4. Epigenetic regulation of post-transcriptional machinery - p. 69 13. Chapter 5. Post-transcriptional regulation: a less explored territory in the world of neurodegenerative diseases - p. 89 14. Chapter 6. Role of post-transcriptional gene regulation in hematological malignancies - p. 105 15. Chapter 7. Post-transcriptional gene regulation in solid tumors - p. 119 16. Chapter 8. A comprehensive view of the prostate cancer metastasis and role of androgen receptor splice variants - p. 149 17. Chapter 9. Post-transcriptional gene regulation in Cardiorenal syndrome - p. 167 18. Chapter 10. Noncoding RNAs as modulators of post-transcriptional changes and their role in CVDs - p. 175 19. Chapter 11. microRNAs as critical regulators in heart development and diseases - p. 187 20. Chapter 12. MicroRNA regulation in autoimmune diseases - p. 205 21. Chapter 13. Post-transcriptional regulation of inflammatory disorder - p. 239 22. Chapter 14. Post-transcriptional gene regulation in metabolic syndrome - p. 255 23. Post-transcriptional regulation of HIV-1 gene expression - p. 269 24. Post-transcriptional regulation of gene expression in Entamoeba histolytica - p. 295 25. Post-transcriptional regulation of gene expression in human malaria parasite Plasmodium falciparum - p. 309 26. Chapter 18. Hepcidin-induced degradation of iron exporter ferroportin determines anemia of chronic diseases - p. 329 27. Chapter 19. Post-transcriptional regulation of genes and mitochondrial disorder - p. 343 28. Index - p. 365
