Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA).
This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.
1. Principles of Nucleic Acid Structure - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Preface to the second edition - p. Page v 7. Preface from the first edition - p. Page v 8. List of Illustrations - p. Page vii 9. List of Tables - p. Page viii 10. Chapter 1 : Methods for studying nucleic acid structure - p. Page viii 11. Chapter 2 : The building blocks of DNA and RNA - p. Page 23 12. Chapter 3 : DNA structure as observed in fibres and crystals - p. Page 48 13. Chapter 4 : Non-standard and higher-order DNA structures: DNA–DNA recognition - p. Page 108 14. Chapter 5 : Principles of small molecule–DNA recognition - p. Page 189 15. Chapter 6 : RNA structures and their diversity - p. Page 273 16. Chapter 7 : Principles of protein–DNA recognition - p. Page 337 17. Chapter 8 : RNA binding proteins - p. Page 389 18. Index - p. Page 419
Principles of Nucleic Acid Structure, Second Edition, provides the most complete and concise summary of underlying principles and approaches to studying nucleic acid structure, including discussions of X-ray crystallography, NMR, molecular modelling and databases. The book's focus is on a survey of structures that are especially important for biomedical research and pharmacological applications. This updated edition includes the latest advances relevant to recognition of DNA and RNA by small molecules and proteins, including sections on RNA folding, ribosome structure and antibiotic interactions, DNA quadruplexes, DNA and RNA protein complexes and short interfering RNA (siRNA).
This reference is a must-have for those seeking an authoritative, comprehensive and up-to-date source on all aspects of nucleic acid structure, from basic first principles to details of recent research results.
1. Principles of Nucleic Acid Structure - p. Page i 2. Cover - p. Page i 3. Front Matter - p. Page ii 4. Table of Contents - p. Page iii 5. Copyright - p. Page iv 6. Preface to the second edition - p. Page v 7. Preface from the first edition - p. Page v 8. List of Illustrations - p. Page vii 9. List of Tables - p. Page viii 10. Chapter 1 : Methods for studying nucleic acid structure - p. Page viii 11. Chapter 2 : The building blocks of DNA and RNA - p. Page 23 12. Chapter 3 : DNA structure as observed in fibres and crystals - p. Page 48 13. Chapter 4 : Non-standard and higher-order DNA structures: DNA–DNA recognition - p. Page 108 14. Chapter 5 : Principles of small molecule–DNA recognition - p. Page 189 15. Chapter 6 : RNA structures and their diversity - p. Page 273 16. Chapter 7 : Principles of protein–DNA recognition - p. Page 337 17. Chapter 8 : RNA binding proteins - p. Page 389 18. Index - p. Page 419
