Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice.
With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields.
1. Introduction - p. xix 2. Section I. The Biological Basis of Heritability and Diversity - p. xx 3. Chapter 1. The Nature of Traits, Genes and Variation - p. 3 4. Chapter 2. Molecular Biology of Genetic Variants - p. 11 5. Chapter 3. Regulation of Gene Expression - p. 17 6. Chapter 4. The Role of Nutrition in DNA Replication, DNA Damage Prevention and DNA Repair - p. 27 7. Chapter 5. Genotyping and Sequencing - p. 33 8. Chapter 6. RNA Analyses - p. 41 9. Chapter 7. Methods for Global Nutrigenomics and Precision Nutrition - p. 49 10. Chapter 8. Epigenetic Analyses Tools for Nutrition Research - p. 59 11. Chapter 9. Proteomic Analyses - p. 69 12. Chapter 10. Metabolomics for Biomarker Discovery and to Derive Genetic Links to Disease - p. 75 13. Chapter 11. Metagenomics - p. 81 14. Chapter 12. A Broader View on Omics and Systems Biology - p. 89 15. Chapter 13. Study Designs in Genomic Epidemiology - p. 99 16. Chapter 14. Epistemology of Nutrigenetic Knowledge - p. 107 17. Section II. Nutrigenetics - p. 110 18. Chapter 15. Nutrigenetics and the Early Life Origins of Health and Disease: Effects of Protein Restriction - p. 113 19. Chapter 16. Maternal Perinatal Nutrition and Offspring Programming - p. 121 20. Chapter 17. Introduction to Epigenetics - p. 129 21. Chapter 18. Genetics of Chrononutrition - p. 141 22. Chapter 19. Screening for Inborn Errors of Metabolism - p. 153 23. Chapter 20. Genomics of Eating Behavior and Appetite Regulation - p. 159 24. Chapter 21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness - p. 167 25. Chapter 22. Genetic Regulation of Energy Homeostasis: Obesity Implications - p. 175 26. Chapter 23. Genetic Variations With Influence on the Individualized Response to Weight Loss Diets: FTO as Evidence - p. 181 27. Chapter 24. Genetic Variation in the Response to Exercise Training: Impact on Physical Fitness and Performance - p. 187 28. Chapter 25. Genetic Variations Impacting the Response to Defined Diets - p. 197 29. Chapter 26. Carbohydrates and Nutrigenetics - p. 203 30. Chapter 27. Gene-Diet Interactions and Cardiovascular Diseases: Saturated and Monounsaturated Fat - p. 211 31. Chapter 28. Nutrigenetics: Omega-3 and Omega-6 Fatty Acids - p. 223 32. Chapter 29. Nutrigenetics and Blood Cholesterol Levels in Response to Plant Sterols - p. 227 33. Chapter 30. Genetic Individuality and Alcohol Consumption - p. 231 34. Chapter 31. Vitamin A and Other Carotenoids - p. 237 35. Chapter 32. Vitamin D - p. 245 36. Chapter 33. Genetic Determinants of Vitamin E Status - p. 255 37. Chapter 34. Vitamin K - p. 263 38. Chapter 35. Vitamins as Cofactors for Energy Homeostasis and Their Genomic Control, With Special Reference to Biotin, Thiamine, and Pantothenic Acid - p. 271 39. Chapter 36. Impact of Genetic Variation on Vitamin C Status - p. 279 40. Chapter 37. Riboflavin - p. 283 41. Chapter 38. Niacin - p. 287 42. Chapter 39. Folate and Vitamins B6 and B12 - p. 295 43. Chapter 40. The Nutrigenetics of Choline - p. 303 44. Chapter 41. Electrolytes - p. 309 45. Chapter 42. Iron - p. 317 46. Chapter 43. Trace Elements - p. 321 47. Chapter 44. Polyphenols and Nutrigenetic/Nutrigenomic Associations With Obesity-Related Metabolic Diseases - p. 327 48. Chapter 45. Caffeine - p. 335 49. Chapter 46. Phytanic Acid Metabolism in Health and Disease - p. 341 50. Chapter 47. Nutrigenetics, Fatty Acids, and Cognition - p. 347 51. Chapter 48. The Nutrigenetics of Cardiovascular Disease - p. 355 52. Chapter 49. Hemostasis and Thrombosis - p. 361 53. Chapter 50. Diet–Gene Interactions: Perspectives in Insulin Resistance and Type 2 Diabetes - p. 371 54. Chapter 51. Nutrigenetics of Bone Health - p. 377 55. Chapter 52. Nutrients and Genes in the Liver: The Central Role of Liver X Receptor in Lipogenesis - p. 383 56. Chapter 53. Hyperuricemia and Gout - p. 389 57. Chapter 54. Aging: Mechanisms, Signaling and Dietary Intervention - p. 395 58. Chapter 55. Epigenetics in Food Allergies: The Missing Piece of the Puzzle - p. 403 59. Chapter 56. Gut Microbiota and Their Influence on Response to Food - p. 411 60. Section III. Nutrigenomics - p. 419 61. Chapter 57. Nutrients and Gene Expression in Development - p. 423 62. Chapter 58. Nutrients, Obesity and Gene Expression - p. 431 63. Chapter 59. Nutrients and Gene Expression in Type 2 Diabetes - p. 441 64. Chapter 60. Gene Expression in Dyslipidemias - p. 447 65. Chapter 61. Nutrients and Gene Expression in Inflammation - p. 457 66. Chapter 62. Nutrients and Gene Expression in Cardiovascular Disease - p. 469 67. Chapter 63. Nutrients and Gene Expression in Cancer - p. 483 68. Chapter 64. Nutrients and Gene Expression Affecting Bone Metabolism - p. 489 69. Section IV. Translational Nutrigenetics and Nutrigenomics - p. 495 70. Chapter 65. Precision Nutrition Interventions Based on Personalized Genetic Advice - p. 499 71. Chapter 66. Genetically Informed Nutrition Guidance - p. 509 72. Chapter 67. Nutrigenomics of Food Pesticides - p. 513 73. Chapter 68. Pharmaconutrigenetics: The Impact of Genetics on Nutrient–Drug Interactions - p. 519 74. Chapter 69. Setting Genome-Directed Guidelines and Algorithms - p. 525 75. Chapter 70. Direct-to-Consumer Testing - p. 529 76. Chapter 71. Privacy Risks and Protective Measures - p. 539 77. Chapter 72. Ethical Considerations in Nutrigenetics and Nutrigenomics - p. 543 78. Chapter 73. Impact of Nutrigenetics and Nutrigenomics on Society - p. 549 79. Index - p. 557
Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is the most comprehensive foundational text on the complex topics of nutrigenetics and nutrigenomics. Edited by three leaders in the field with contributions from the most well-cited researchers conducting groundbreaking research in the field, the book covers how the genetic makeup influences the response to foods and nutrients and how nutrients affect gene expression. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is broken into four parts providing a valuable overview of genetics, nutrigenetics, and nutrigenomics, and a conclusion that helps to translate research into practice.
With an overview of the background, evidence, challenges, and opportunities in the field, readers will come away with a strong understanding of how this new science is the frontier of medical nutrition. Principles of Nutrigenetics and Nutrigenomics: Fundamentals for Individualized Nutrition is a valuable reference for students and researchers studying nutrition, genetics, medicine, and related fields.
1. Introduction - p. xix 2. Section I. The Biological Basis of Heritability and Diversity - p. xx 3. Chapter 1. The Nature of Traits, Genes and Variation - p. 3 4. Chapter 2. Molecular Biology of Genetic Variants - p. 11 5. Chapter 3. Regulation of Gene Expression - p. 17 6. Chapter 4. The Role of Nutrition in DNA Replication, DNA Damage Prevention and DNA Repair - p. 27 7. Chapter 5. Genotyping and Sequencing - p. 33 8. Chapter 6. RNA Analyses - p. 41 9. Chapter 7. Methods for Global Nutrigenomics and Precision Nutrition - p. 49 10. Chapter 8. Epigenetic Analyses Tools for Nutrition Research - p. 59 11. Chapter 9. Proteomic Analyses - p. 69 12. Chapter 10. Metabolomics for Biomarker Discovery and to Derive Genetic Links to Disease - p. 75 13. Chapter 11. Metagenomics - p. 81 14. Chapter 12. A Broader View on Omics and Systems Biology - p. 89 15. Chapter 13. Study Designs in Genomic Epidemiology - p. 99 16. Chapter 14. Epistemology of Nutrigenetic Knowledge - p. 107 17. Section II. Nutrigenetics - p. 110 18. Chapter 15. Nutrigenetics and the Early Life Origins of Health and Disease: Effects of Protein Restriction - p. 113 19. Chapter 16. Maternal Perinatal Nutrition and Offspring Programming - p. 121 20. Chapter 17. Introduction to Epigenetics - p. 129 21. Chapter 18. Genetics of Chrononutrition - p. 141 22. Chapter 19. Screening for Inborn Errors of Metabolism - p. 153 23. Chapter 20. Genomics of Eating Behavior and Appetite Regulation - p. 159 24. Chapter 21. Genetics of Body Composition: From Severe Obesity to Extreme Leanness - p. 167 25. Chapter 22. Genetic Regulation of Energy Homeostasis: Obesity Implications - p. 175 26. Chapter 23. Genetic Variations With Influence on the Individualized Response to Weight Loss Diets: FTO as Evidence - p. 181 27. Chapter 24. Genetic Variation in the Response to Exercise Training: Impact on Physical Fitness and Performance - p. 187 28. Chapter 25. Genetic Variations Impacting the Response to Defined Diets - p. 197 29. Chapter 26. Carbohydrates and Nutrigenetics - p. 203 30. Chapter 27. Gene-Diet Interactions and Cardiovascular Diseases: Saturated and Monounsaturated Fat - p. 211 31. Chapter 28. Nutrigenetics: Omega-3 and Omega-6 Fatty Acids - p. 223 32. Chapter 29. Nutrigenetics and Blood Cholesterol Levels in Response to Plant Sterols - p. 227 33. Chapter 30. Genetic Individuality and Alcohol Consumption - p. 231 34. Chapter 31. Vitamin A and Other Carotenoids - p. 237 35. Chapter 32. Vitamin D - p. 245 36. Chapter 33. Genetic Determinants of Vitamin E Status - p. 255 37. Chapter 34. Vitamin K - p. 263 38. Chapter 35. Vitamins as Cofactors for Energy Homeostasis and Their Genomic Control, With Special Reference to Biotin, Thiamine, and Pantothenic Acid - p. 271 39. Chapter 36. Impact of Genetic Variation on Vitamin C Status - p. 279 40. Chapter 37. Riboflavin - p. 283 41. Chapter 38. Niacin - p. 287 42. Chapter 39. Folate and Vitamins B6 and B12 - p. 295 43. Chapter 40. The Nutrigenetics of Choline - p. 303 44. Chapter 41. Electrolytes - p. 309 45. Chapter 42. Iron - p. 317 46. Chapter 43. Trace Elements - p. 321 47. Chapter 44. Polyphenols and Nutrigenetic/Nutrigenomic Associations With Obesity-Related Metabolic Diseases - p. 327 48. Chapter 45. Caffeine - p. 335 49. Chapter 46. Phytanic Acid Metabolism in Health and Disease - p. 341 50. Chapter 47. Nutrigenetics, Fatty Acids, and Cognition - p. 347 51. Chapter 48. The Nutrigenetics of Cardiovascular Disease - p. 355 52. Chapter 49. Hemostasis and Thrombosis - p. 361 53. Chapter 50. Diet–Gene Interactions: Perspectives in Insulin Resistance and Type 2 Diabetes - p. 371 54. Chapter 51. Nutrigenetics of Bone Health - p. 377 55. Chapter 52. Nutrients and Genes in the Liver: The Central Role of Liver X Receptor in Lipogenesis - p. 383 56. Chapter 53. Hyperuricemia and Gout - p. 389 57. Chapter 54. Aging: Mechanisms, Signaling and Dietary Intervention - p. 395 58. Chapter 55. Epigenetics in Food Allergies: The Missing Piece of the Puzzle - p. 403 59. Chapter 56. Gut Microbiota and Their Influence on Response to Food - p. 411 60. Section III. Nutrigenomics - p. 419 61. Chapter 57. Nutrients and Gene Expression in Development - p. 423 62. Chapter 58. Nutrients, Obesity and Gene Expression - p. 431 63. Chapter 59. Nutrients and Gene Expression in Type 2 Diabetes - p. 441 64. Chapter 60. Gene Expression in Dyslipidemias - p. 447 65. Chapter 61. Nutrients and Gene Expression in Inflammation - p. 457 66. Chapter 62. Nutrients and Gene Expression in Cardiovascular Disease - p. 469 67. Chapter 63. Nutrients and Gene Expression in Cancer - p. 483 68. Chapter 64. Nutrients and Gene Expression Affecting Bone Metabolism - p. 489 69. Section IV. Translational Nutrigenetics and Nutrigenomics - p. 495 70. Chapter 65. Precision Nutrition Interventions Based on Personalized Genetic Advice - p. 499 71. Chapter 66. Genetically Informed Nutrition Guidance - p. 509 72. Chapter 67. Nutrigenomics of Food Pesticides - p. 513 73. Chapter 68. Pharmaconutrigenetics: The Impact of Genetics on Nutrient–Drug Interactions - p. 519 74. Chapter 69. Setting Genome-Directed Guidelines and Algorithms - p. 525 75. Chapter 70. Direct-to-Consumer Testing - p. 529 76. Chapter 71. Privacy Risks and Protective Measures - p. 539 77. Chapter 72. Ethical Considerations in Nutrigenetics and Nutrigenomics - p. 543 78. Chapter 73. Impact of Nutrigenetics and Nutrigenomics on Society - p. 549 79. Index - p. 557
