Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology.
This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Theories and definitions of tumors - p. 9 3. Chapter 3. Etiopathogenesis of tumors - p. 47 4. Chapter 4. Growth of cells, growth factors, and oncogenes - p. 87 5. Chapter 5. Hereditary predispositions to tumors, tumor suppressor genes, and their clinico-genomic complexities - p. 105 6. Chapter 6. The tumor types: The complexities in the combinations and variabilities of their traits - p. 145 7. Chapter 7. Epidemiology of tumors - p. 187 8. Chapter 8. Prevention of tumors - p. 209 9. Chapter 9. Clinical features of tumors - p. 263 10. Chapter 10. Typing, grading, and staging of cases of tumor - p. 279 11. Chapter 11. Endoscopic visualization and imaging assessments of cases of tumor - p. 317 12. Chapter 12. Principles of surgery for tumors - p. 339 13. Chapter 13. Principles of nonsurgical therapies - p. 355 14. Chapter 14. Aspects of radiation therapy - p. 375 15. Chapter 15. Specific aspects of cytotoxic and hormonal drug therapies - p. 389 16. Chapter 16. Immunotherapies - p. 419 17. Chapter 17. Gene therapies not related to immunological therapies - p. 439 18. Chapter 18. Less common and controversial therapies - p. 453 19. Chapter 19. Care after primary therapy - p. 461 20. Chapter 20. Costs, ethics, and malpractice litigation - p. 473 21. Appendix 1. Principles of normal embryology, histology, and related cell biology - p. 495 22. Appendix 2. Aspects of the normal genome - p. 525 23. Appendix 3. Fixed genomic events and possible mechanisms of their causation by etiological agents - p. 547 24. Appendix 4. Genomic instabilities: kind, effects, and roles in the immortality of tumor cell populations - p. 571 25. Appendix 5. Methods in histologic and molecular assessments of tumors - p. 581 26. Appendix 6. “Biomarkers” in molecular pathology and oncology - p. 597 27. Appendix 7. Sublethal injuries and deaths of cells and tissues - p. 603 28. Appendix 8. “Pretarget,” “target,” and recovery capacity defenses of cells against carcinogens and cytotoxic agents - p. 625 29. Appendix 9. Developing and testing new therapies: clinical trials - p. 633 30. Index - p. 647
Principles of Tumors: A Translational Approach to Foundations, Second Edition, provides a concise summary of translational/interdisciplinary topics on the various aspects of tumors, especially abnormalities in their cells, their causes and effects on patients. Topics discussed include how genomic abnormalities in tumors may result from the actions of carcinogens and how genomic changes determine the cell biological/morphological abnormalities in tumor cell populations. In addition, the relationships between tumor cell genomics and therapeutic outcomes are described. There are also supporting appendices on general bioscience, including the principles of histology (the cells and tissues of the body), genetics, pathology, radiology and pharmacology.
This book gives a thorough, detailed, yet concise account of the main bioscience, clinical and therapeutic aspects of tumors. It emphasizes the translational aspects of research into tumors with extensive discussions of interdisciplinary issues. The content in this book will be invaluable for researchers and clinicians involved in collaborative projects where it is necessary to understand fundamental issues in other branches of biomedicine.
1. Chapter 1. Introduction - p. 1 2. Chapter 2. Theories and definitions of tumors - p. 9 3. Chapter 3. Etiopathogenesis of tumors - p. 47 4. Chapter 4. Growth of cells, growth factors, and oncogenes - p. 87 5. Chapter 5. Hereditary predispositions to tumors, tumor suppressor genes, and their clinico-genomic complexities - p. 105 6. Chapter 6. The tumor types: The complexities in the combinations and variabilities of their traits - p. 145 7. Chapter 7. Epidemiology of tumors - p. 187 8. Chapter 8. Prevention of tumors - p. 209 9. Chapter 9. Clinical features of tumors - p. 263 10. Chapter 10. Typing, grading, and staging of cases of tumor - p. 279 11. Chapter 11. Endoscopic visualization and imaging assessments of cases of tumor - p. 317 12. Chapter 12. Principles of surgery for tumors - p. 339 13. Chapter 13. Principles of nonsurgical therapies - p. 355 14. Chapter 14. Aspects of radiation therapy - p. 375 15. Chapter 15. Specific aspects of cytotoxic and hormonal drug therapies - p. 389 16. Chapter 16. Immunotherapies - p. 419 17. Chapter 17. Gene therapies not related to immunological therapies - p. 439 18. Chapter 18. Less common and controversial therapies - p. 453 19. Chapter 19. Care after primary therapy - p. 461 20. Chapter 20. Costs, ethics, and malpractice litigation - p. 473 21. Appendix 1. Principles of normal embryology, histology, and related cell biology - p. 495 22. Appendix 2. Aspects of the normal genome - p. 525 23. Appendix 3. Fixed genomic events and possible mechanisms of their causation by etiological agents - p. 547 24. Appendix 4. Genomic instabilities: kind, effects, and roles in the immortality of tumor cell populations - p. 571 25. Appendix 5. Methods in histologic and molecular assessments of tumors - p. 581 26. Appendix 6. “Biomarkers” in molecular pathology and oncology - p. 597 27. Appendix 7. Sublethal injuries and deaths of cells and tissues - p. 603 28. Appendix 8. “Pretarget,” “target,” and recovery capacity defenses of cells against carcinogens and cytotoxic agents - p. 625 29. Appendix 9. Developing and testing new therapies: clinical trials - p. 633 30. Index - p. 647
