Progress in Medicinal Chemistry, Volume 63 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Specific chapters in this release include Harnessing conformational drivers in drug design, Recent Advances in the Medicinal Chemistry of Heterobifunctional Derivatives for Protein Homeostasis, and A Decade of Antimalarial Drug Discovery: New Targets, Tools and Molecules.
1. Introduction - p. 62 2. 1 Recent advances in the medicinal chemistry of heterobifunctional degraders - p. 63 3. 2 Recent advances in the screening of heterobifunctional degraders - p. 85 4. 3 Extending the repertoire of E3 ligases - p. 99 5. 4 Heterobifunctional degraders beyond E3 ligase recruiters - p. 109 6. 5 Advances in our understanding of heterobifunctional degrader DMPK - p. 122 7. 6 Advances in the scale-up of heterobifunctional degraders for clinical supply—Challenges and solutions - p. 134 8. 7 Heterobunctional bifunctional degraders in the clinic - p. 140 9. Summary and outlook - p. 143 10. Acknowledgements - p. 144 11. References - p. 144 12. Chapter Three: Another decade of antimalarial drug discovery: New targets, tools and molecules - p. 166
Progress in Medicinal Chemistry, Volume 63 highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors. Specific chapters in this release include Harnessing conformational drivers in drug design, Recent Advances in the Medicinal Chemistry of Heterobifunctional Derivatives for Protein Homeostasis, and A Decade of Antimalarial Drug Discovery: New Targets, Tools and Molecules.
1. Introduction - p. 62 2. 1 Recent advances in the medicinal chemistry of heterobifunctional degraders - p. 63 3. 2 Recent advances in the screening of heterobifunctional degraders - p. 85 4. 3 Extending the repertoire of E3 ligases - p. 99 5. 4 Heterobifunctional degraders beyond E3 ligase recruiters - p. 109 6. 5 Advances in our understanding of heterobifunctional degrader DMPK - p. 122 7. 6 Advances in the scale-up of heterobifunctional degraders for clinical supply—Challenges and solutions - p. 134 8. 7 Heterobunctional bifunctional degraders in the clinic - p. 140 9. Summary and outlook - p. 143 10. Acknowledgements - p. 144 11. References - p. 144 12. Chapter Three: Another decade of antimalarial drug discovery: New targets, tools and molecules - p. 166
