Quantitative Human Physiology: An Introduction, winner of a 2018 Textbook Excellence Award (Texty), is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time, but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects.
NEW FOR THE SECOND EDITION
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Preface - p. ix 6. Acknowledgments - p. xiii 7. Unit 1: Physical and Chemical Foundations of Physiology - p. xiv 8. 1.1. The Core Principles of Physiology - p. 3 9. 1.2. Physical Foundations of Physiology I: Pressure-Driven Flow - p. 15 10. 1.3. Physical Foundations of Physiology II: Electrical Force, Potential, Capacitance, and Current - p. 31 11. Problem Set 1.1. Physical Foundations: Pressure and Electrical Forces and Flows - p. 43 12. 1.4. Chemical Foundations of Physiology I: Chemical Energy and Intermolecular Forces - p. 46 13. 1.5. Chemical Foundations of Physiology II: Concentration and Kinetics - p. 59 14. 1.6. Diffusion - p. 75 15. 1.7. Electrochemical Potential and Free Energy - p. 87 16. Problem Set 1.2. Kinetics and Diffusion - p. 94 17. Unit 2: Membranes, Transport, and Metabolism - p. 97 18. 2.1. Cell Structure - p. 101 19. 2.2. DNA and Protein Synthesis - p. 120 20. 2.3. Protein Structure - p. 130 21. 2.4. Biological Membranes - p. 142 22. Problem Set 2.1. Surface Tension, Membrane Surface Tension, Membrane Structure, Microscopic Resolution, and Cell Fractionation - p. 156 23. 2.5. Passive Transport and Facilitated Diffusion - p. 161 24. 2.6. Active Transport: Pumps and Exchangers - p. 170 25. 2.7. Osmosis and Osmotic Pressure - p. 182 26. Problem Set 2.2. Membrane Transport - p. 199 27. 2.8. Cell Signaling - p. 205 28. 2.9. ATP Production I: Glycolysis - p. 218 29. 2.10. ATP Production II: The TCA Cycle and Oxidative Phosphorylation - p. 227 30. 2.11. ATP Production III: Fatty Acid Oxidation and Amino Acid Oxidation - p. 241 31. Unit 3: Physiology of Excitable Cells - p. 252 32. 3.1. The Origin of the Resting Membrane Potential - p. 255 33. 3.2. The Action Potential - p. 265 34. 3.3. Propagation of the Action Potential - p. 280 35. Problem Set 3.1. Membrane Potential, Action Potential, and Nerve Conduction - p. 289 36. 3.4. Skeletal Muscle Mechanics - p. 292 37. 3.5. Contractile Mechanisms in Skeletal Muscle - p. 305 38. 3.6. The Neuromuscular Junction and Excitation–Contraction Coupling - p. 318 39. 3.7. Muscle Energetics, Fatigue, and Training - p. 334 40. Problem Set 3.2. Neuromuscular Transmission, Muscle Force, and Energetics - p. 349 41. 3.8. Smooth Muscle - p. 351 42. Unit 4: The Nervous System - p. 361 43. 4.1. Organization of the Nervous System - p. 365 44. 4.2. Cells, Synapses, and Neurotransmitters - p. 375 45. 4.3. Cutaneous Sensory Systems - p. 389 46. 4.4. Spinal Reflexes - p. 400 47. 4.5. Balance and Control of Movement - p. 409 48. Problem Set 4.1. Nerve Conduction - p. 422 49. 4.6. The Chemical Senses - p. 427 50. 4.7. Hearing - p. 440 51. 4.8. Vision - p. 456 52. 4.2 Problem Set. Sensory Transduction - p. 471 53. 4.9. Autonomic Nervous System - p. 473 54. Unit 5: The Cardiovascular System - p. 486 55. 5.1. Overview of the Cardiovascular System and the Blood - p. 489 56. 5.2. Plasma and Red Blood Cells - p. 498 57. 5.3. White Blood Cells and Inflammation - p. 507 58. 5.4. The Heart as a Pump - p. 516 59. Problem Set 5.1. Blood - p. 525 60. 5.5. The Cardiac Action Potential - p. 528 61. 5.6. The Electrocardiogram - p. 537 62. 5.7. The Cellular Basis of Cardiac Contractility - p. 547 63. 5.8. The Cardiac Function Curve - p. 556 64. Problem Set 5.2. Cardiac Work - p. 565 65. 5.9. Vascular Function: Hemodynamics - p. 568 66. 5.10. The Microcirculation and Solute Exchange - p. 578 67. 5.11. Regulation of Perfusion - p. 589 68. 5.12. Integration of Cardiac Output and Venous Return - p. 599 69. 5.13. Regulation of Arterial Pressure - p. 608 70. Problem Set 5.3. Hemodynamics and Microcirculation - p. 619 71. Unit 6: Respiratory Physiology - p. 620 72. 6.1. The Mechanics of Breathing - p. 623 73. 6.2. Lung Volumes and Airway Resistance - p. 633 74. 6.3. Gas Exchange in the Lungs - p. 642 75. Problem Set 6.1. Airway Resistance and Alveolar Gas Exchange - p. 653 76. 6.4. Oxygen and Carbon Dioxide Transport - p. 656 77. 6.5. Acid–Base Physiology I: The Bicarbonate Buffer System and Respiratory Compensation - p. 665 78. 6.6. Control of Ventilation - p. 672 79. Problem Set 6.2. Gas Transport and pH Disturbances - p. 682 80. Unit 7: Renal Physiology - p. 685 81. 7.1. Body Fluid Compartments - p. 689 82. 7.2. Functional Anatomy of the Kidneys and Overview of Kidney Function - p. 698 83. 7.3. Glomerular Filtration - p. 705 84. Problem Set 7.1. Fluid Volumes, Glomerular Filtration, and Clearance - p. 715 85. 7.4. Tubular Reabsorption and Secretion - p. 719 86. 7.5. Mechanism of Concentration and Dilution of Urine - p. 730 87. 7.6. Regulation of Fluid and Electrolyte Balance - p. 740 88. 7.7. Renal Component of Acid–Base Balance - p. 752 89. Problem Set 7.2. Fluid and Electrolyte Balance and Acid–Base Balance - p. 765 90. Unit 8: Gastrointestinal Physiology - p. 767 91. 8.1. Mouth and Esophagus - p. 771 92. 8.2. The Stomach - p. 785 93. 8.3. Intestinal and Colonic Chemoreception and Motility - p. 796 94. 8.4. Pancreatic and Biliary Secretion - p. 810 95. 8.5. Digestion and Absorption of the Macronutrients - p. 821 96. 8.6. Energy Balance and Regulation of Food Intake - p. 834 97. Problem Set 8.1. Energy Balance - p. 847 98. Unit 9: Endocrine Physiology - p. 849 99. 9.1. General Principles of Endocrinology - p. 853 100. 9.2. Hypothalamus and Pituitary Gland - p. 870 101. 9.3. The Thyroid Gland - p. 883 102. 9.4. The Endocrine Pancreas and Control of Blood Glucose - p. 895 103. 9.5. The Adrenal Cortex - p. 906 104. 9.6. The Adrenal Medulla and Integration of Metabolic Control - p. 916 105. 9.7. Calcium and Phosphorus Homeostasis I: The Calcitropic Hormones - p. 924 106. 9.8. Calcium and Phosphorus Homeostasis II: Target Tissues and Integrated Control - p. 933 107. 9.9. Female Reproductive Physiology - p. 946 108. 9.10. Male Reproductive Physiology - p. 956 109. Problem Set 9.1. Ligand Binding - p. 967 110. Appendix I. Important Equations - p. 969 111. Appendix II. Important Physical Constants for Physiology - p. 981 112. Index - p. 983
Quantitative Human Physiology: An Introduction, winner of a 2018 Textbook Excellence Award (Texty), is the first text to meet the needs of the undergraduate bioengineering student who is being exposed to physiology for the first time, but requires a more analytical/quantitative approach. This book explores how component behavior produces system behavior in physiological systems. Through text explanation, figures, and equations, it provides the engineering student with a basic understanding of physiological principles with an emphasis on quantitative aspects.
NEW FOR THE SECOND EDITION
1. Cover image - p. Cover 2. Title page - p. iii 3. Table of Contents - p. iii 4. Copyright - p. iv 5. Preface - p. ix 6. Acknowledgments - p. xiii 7. Unit 1: Physical and Chemical Foundations of Physiology - p. xiv 8. 1.1. The Core Principles of Physiology - p. 3 9. 1.2. Physical Foundations of Physiology I: Pressure-Driven Flow - p. 15 10. 1.3. Physical Foundations of Physiology II: Electrical Force, Potential, Capacitance, and Current - p. 31 11. Problem Set 1.1. Physical Foundations: Pressure and Electrical Forces and Flows - p. 43 12. 1.4. Chemical Foundations of Physiology I: Chemical Energy and Intermolecular Forces - p. 46 13. 1.5. Chemical Foundations of Physiology II: Concentration and Kinetics - p. 59 14. 1.6. Diffusion - p. 75 15. 1.7. Electrochemical Potential and Free Energy - p. 87 16. Problem Set 1.2. Kinetics and Diffusion - p. 94 17. Unit 2: Membranes, Transport, and Metabolism - p. 97 18. 2.1. Cell Structure - p. 101 19. 2.2. DNA and Protein Synthesis - p. 120 20. 2.3. Protein Structure - p. 130 21. 2.4. Biological Membranes - p. 142 22. Problem Set 2.1. Surface Tension, Membrane Surface Tension, Membrane Structure, Microscopic Resolution, and Cell Fractionation - p. 156 23. 2.5. Passive Transport and Facilitated Diffusion - p. 161 24. 2.6. Active Transport: Pumps and Exchangers - p. 170 25. 2.7. Osmosis and Osmotic Pressure - p. 182 26. Problem Set 2.2. Membrane Transport - p. 199 27. 2.8. Cell Signaling - p. 205 28. 2.9. ATP Production I: Glycolysis - p. 218 29. 2.10. ATP Production II: The TCA Cycle and Oxidative Phosphorylation - p. 227 30. 2.11. ATP Production III: Fatty Acid Oxidation and Amino Acid Oxidation - p. 241 31. Unit 3: Physiology of Excitable Cells - p. 252 32. 3.1. The Origin of the Resting Membrane Potential - p. 255 33. 3.2. The Action Potential - p. 265 34. 3.3. Propagation of the Action Potential - p. 280 35. Problem Set 3.1. Membrane Potential, Action Potential, and Nerve Conduction - p. 289 36. 3.4. Skeletal Muscle Mechanics - p. 292 37. 3.5. Contractile Mechanisms in Skeletal Muscle - p. 305 38. 3.6. The Neuromuscular Junction and Excitation–Contraction Coupling - p. 318 39. 3.7. Muscle Energetics, Fatigue, and Training - p. 334 40. Problem Set 3.2. Neuromuscular Transmission, Muscle Force, and Energetics - p. 349 41. 3.8. Smooth Muscle - p. 351 42. Unit 4: The Nervous System - p. 361 43. 4.1. Organization of the Nervous System - p. 365 44. 4.2. Cells, Synapses, and Neurotransmitters - p. 375 45. 4.3. Cutaneous Sensory Systems - p. 389 46. 4.4. Spinal Reflexes - p. 400 47. 4.5. Balance and Control of Movement - p. 409 48. Problem Set 4.1. Nerve Conduction - p. 422 49. 4.6. The Chemical Senses - p. 427 50. 4.7. Hearing - p. 440 51. 4.8. Vision - p. 456 52. 4.2 Problem Set. Sensory Transduction - p. 471 53. 4.9. Autonomic Nervous System - p. 473 54. Unit 5: The Cardiovascular System - p. 486 55. 5.1. Overview of the Cardiovascular System and the Blood - p. 489 56. 5.2. Plasma and Red Blood Cells - p. 498 57. 5.3. White Blood Cells and Inflammation - p. 507 58. 5.4. The Heart as a Pump - p. 516 59. Problem Set 5.1. Blood - p. 525 60. 5.5. The Cardiac Action Potential - p. 528 61. 5.6. The Electrocardiogram - p. 537 62. 5.7. The Cellular Basis of Cardiac Contractility - p. 547 63. 5.8. The Cardiac Function Curve - p. 556 64. Problem Set 5.2. Cardiac Work - p. 565 65. 5.9. Vascular Function: Hemodynamics - p. 568 66. 5.10. The Microcirculation and Solute Exchange - p. 578 67. 5.11. Regulation of Perfusion - p. 589 68. 5.12. Integration of Cardiac Output and Venous Return - p. 599 69. 5.13. Regulation of Arterial Pressure - p. 608 70. Problem Set 5.3. Hemodynamics and Microcirculation - p. 619 71. Unit 6: Respiratory Physiology - p. 620 72. 6.1. The Mechanics of Breathing - p. 623 73. 6.2. Lung Volumes and Airway Resistance - p. 633 74. 6.3. Gas Exchange in the Lungs - p. 642 75. Problem Set 6.1. Airway Resistance and Alveolar Gas Exchange - p. 653 76. 6.4. Oxygen and Carbon Dioxide Transport - p. 656 77. 6.5. Acid–Base Physiology I: The Bicarbonate Buffer System and Respiratory Compensation - p. 665 78. 6.6. Control of Ventilation - p. 672 79. Problem Set 6.2. Gas Transport and pH Disturbances - p. 682 80. Unit 7: Renal Physiology - p. 685 81. 7.1. Body Fluid Compartments - p. 689 82. 7.2. Functional Anatomy of the Kidneys and Overview of Kidney Function - p. 698 83. 7.3. Glomerular Filtration - p. 705 84. Problem Set 7.1. Fluid Volumes, Glomerular Filtration, and Clearance - p. 715 85. 7.4. Tubular Reabsorption and Secretion - p. 719 86. 7.5. Mechanism of Concentration and Dilution of Urine - p. 730 87. 7.6. Regulation of Fluid and Electrolyte Balance - p. 740 88. 7.7. Renal Component of Acid–Base Balance - p. 752 89. Problem Set 7.2. Fluid and Electrolyte Balance and Acid–Base Balance - p. 765 90. Unit 8: Gastrointestinal Physiology - p. 767 91. 8.1. Mouth and Esophagus - p. 771 92. 8.2. The Stomach - p. 785 93. 8.3. Intestinal and Colonic Chemoreception and Motility - p. 796 94. 8.4. Pancreatic and Biliary Secretion - p. 810 95. 8.5. Digestion and Absorption of the Macronutrients - p. 821 96. 8.6. Energy Balance and Regulation of Food Intake - p. 834 97. Problem Set 8.1. Energy Balance - p. 847 98. Unit 9: Endocrine Physiology - p. 849 99. 9.1. General Principles of Endocrinology - p. 853 100. 9.2. Hypothalamus and Pituitary Gland - p. 870 101. 9.3. The Thyroid Gland - p. 883 102. 9.4. The Endocrine Pancreas and Control of Blood Glucose - p. 895 103. 9.5. The Adrenal Cortex - p. 906 104. 9.6. The Adrenal Medulla and Integration of Metabolic Control - p. 916 105. 9.7. Calcium and Phosphorus Homeostasis I: The Calcitropic Hormones - p. 924 106. 9.8. Calcium and Phosphorus Homeostasis II: Target Tissues and Integrated Control - p. 933 107. 9.9. Female Reproductive Physiology - p. 946 108. 9.10. Male Reproductive Physiology - p. 956 109. Problem Set 9.1. Ligand Binding - p. 967 110. Appendix I. Important Equations - p. 969 111. Appendix II. Important Physical Constants for Physiology - p. 981 112. Index - p. 983
