Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS‒mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals‒induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions.
Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. About the author - p. page_xix 6. Preface - p. page_xxi 7. Summary - p. page_xxiii 8. Chapter 1: Pathophysiological, toxicological, and immunoregulatory roles of reactive oxygen and nitrogen species (RONS) - p. page_xxv 9. Chapter 2: Biological mechanisms of reactive oxygen species (ROS) - p. page_18 10. Chapter 3: Cellular signaling pathways with reactive oxygen species (ROS) - p. page_35 11. Chapter 4: Manganese as the essential element in oxidative stress and metabolic diseases - p. page_79 12. Chapter 5: Affected energy metabolism is the primal cause of manganese toxicity - p. page_105 13. Chapter 6: Heavy metals and free radical-induced cell death mechanisms - p. page_130 14. Chapter 7: Cytotoxic mechanisms of xenobiotic heavy metals on oxidative stress - p. page_157 15. Chapter 8: Oxidative stress and oxidative damage-induced cell death - p. page_173 16. Chapter 9: Cell death mechanisms—Apoptosis pathways and their implications in toxicology - p. page_197 17. Chapter 10: Programmed cell death mechanisms and nanoparticle toxicity - p. page_228 18. Chapter 11: Endoplasmic reticulum stress and associated ROS in disease pathophysiology applications - p. page_264 19. Chapter 12: Endoplasmic reticulum stress-induced cell death mechanism - p. page_297 20. Chapter 13: Modulation of endoplasmic reticulum (ER) stress of nanotoxicology for nanoparticles (NPs) - p. page_342 21. Chapter 14: Nanoparticle cellular uptake and intracellular targeting on reactive oxygen species (ROS) in biological activities - p. page_372 22. Chapter 15: Metal nanoparticles (MNPs) and particulate matter (PM) induce toxicity - p. page_395 23. Chapter 16: Mechanisms for nanoparticle-mediated oxidative stress - p. page_419 24. Chapter 17: Nanotechnological modifications of nanoparticles on reactive oxygen and nitrogen species - p. page_447 25. Chapter 18: Medical imaging of the complexity of nanoparticles and ROS dynamics in vivo for clinical diagnosis application - p. page_488 26. Chapter 19: Titanium dioxide nanoparticle-induced cytotoxicity and genotoxicity—Generation of reactive oxygen species and cell damage - p. page_534 27. Chapter 20: Toxicity of ZnO nanoparticle-induced reactive oxygen species and cancer cells - p. page_559 28. Chapter 21: Silver nanoparticles induce cellular cytotoxicity, genotoxicity, DNA damage, and cell death - p. page_587 29. Chapter 22: Correlations between oxidative stress and aligning nanoparticle safety assessments - p. page_622 30. Chapter 23: Effects of interactions between antioxidant defense therapy and ROS - p. page_644 31. Chapter 24: FDA breakthrough—Drug therapy designations for clinical evidence - p. page_691 32. List of abbreviations - p. page_729 33. Index - p. page_743
Reactive Oxygen Species (ROS), Nanoparticles, and Endoplasmic Reticulum (ER) Stress-Induced Cell Death Mechanisms presents the role of ROS‒mediated pathways cellular signaling stress, endoplasmic reticulum (ER) stress, oxidative stress, oxidative damage, nanomaterials, and the mechanisms by which metalloids and nanoparticles induce their toxic effects. The book covers the ecotoxicology of environmental heavy metal ions and free radicals on macromolecules cells organisms, heavy metals‒induced cell responses, oxidative stress, the source of oxidants, and the roles of ROS, oxidative stress and oxidative damage mechanisms. It also examines the nanotoxicity, cytotoxicity and genotoxicity mechanisms of nanomaterials and the effects of nanoparticle interactions.
Antioxidant defense therapy and strategies for treatment round out the book, making it an ideal resource for researchers and professional scientists in toxicology, environmental chemistry, environmental science, nanomaterials and the pharmaceutical sciences.
1. Cover image - p. page_i 2. Title page - p. page_i 3. Table of Contents - p. page_i 4. Copyright - p. page_iv 5. About the author - p. page_xix 6. Preface - p. page_xxi 7. Summary - p. page_xxiii 8. Chapter 1: Pathophysiological, toxicological, and immunoregulatory roles of reactive oxygen and nitrogen species (RONS) - p. page_xxv 9. Chapter 2: Biological mechanisms of reactive oxygen species (ROS) - p. page_18 10. Chapter 3: Cellular signaling pathways with reactive oxygen species (ROS) - p. page_35 11. Chapter 4: Manganese as the essential element in oxidative stress and metabolic diseases - p. page_79 12. Chapter 5: Affected energy metabolism is the primal cause of manganese toxicity - p. page_105 13. Chapter 6: Heavy metals and free radical-induced cell death mechanisms - p. page_130 14. Chapter 7: Cytotoxic mechanisms of xenobiotic heavy metals on oxidative stress - p. page_157 15. Chapter 8: Oxidative stress and oxidative damage-induced cell death - p. page_173 16. Chapter 9: Cell death mechanisms—Apoptosis pathways and their implications in toxicology - p. page_197 17. Chapter 10: Programmed cell death mechanisms and nanoparticle toxicity - p. page_228 18. Chapter 11: Endoplasmic reticulum stress and associated ROS in disease pathophysiology applications - p. page_264 19. Chapter 12: Endoplasmic reticulum stress-induced cell death mechanism - p. page_297 20. Chapter 13: Modulation of endoplasmic reticulum (ER) stress of nanotoxicology for nanoparticles (NPs) - p. page_342 21. Chapter 14: Nanoparticle cellular uptake and intracellular targeting on reactive oxygen species (ROS) in biological activities - p. page_372 22. Chapter 15: Metal nanoparticles (MNPs) and particulate matter (PM) induce toxicity - p. page_395 23. Chapter 16: Mechanisms for nanoparticle-mediated oxidative stress - p. page_419 24. Chapter 17: Nanotechnological modifications of nanoparticles on reactive oxygen and nitrogen species - p. page_447 25. Chapter 18: Medical imaging of the complexity of nanoparticles and ROS dynamics in vivo for clinical diagnosis application - p. page_488 26. Chapter 19: Titanium dioxide nanoparticle-induced cytotoxicity and genotoxicity—Generation of reactive oxygen species and cell damage - p. page_534 27. Chapter 20: Toxicity of ZnO nanoparticle-induced reactive oxygen species and cancer cells - p. page_559 28. Chapter 21: Silver nanoparticles induce cellular cytotoxicity, genotoxicity, DNA damage, and cell death - p. page_587 29. Chapter 22: Correlations between oxidative stress and aligning nanoparticle safety assessments - p. page_622 30. Chapter 23: Effects of interactions between antioxidant defense therapy and ROS - p. page_644 31. Chapter 24: FDA breakthrough—Drug therapy designations for clinical evidence - p. page_691 32. List of abbreviations - p. page_729 33. Index - p. page_743
