Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete.
Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of Contributors - p. xiii 7. About the editors - p. xxiii 8. Preface - p. xxv 9. Chapter 1. Recent innovation in crop protection research - p. 1 10. Chapter 2. Status and potential of bioprotection products for crop protection - p. 25 11. Chapter 3. Research and development of green pesticides in China - p. 39 12. Chapter 4. Agrochemical disease control: The story so far - p. 65 13. Chapter 5. Plant defense priming in the field: a review - p. 87 14. Chapter 6. Reaching beyond crop protection: Synergism between agricultural development and malaria eradication - p. 125 15. Chapter 7. Discovery and optimization of a novel insecticide, broflanilide - p. 145 16. Chapter 8. Studies on a novel insecticide, fluxametamide - p. 157 17. Chapter 9. The discovery of isocycloseram: A novel isoxazoline insecticide - p. 165 18. Chapter 10. Cyclaniliprole: A novel diamide insecticide - p. 213 19. Optimization of mesoionic pyrido[1,2-a]pyrimidinone insecticides and discovery of 3-biaryl analogs controlling Lepidoptera species - p. 221 20. Chapter 12. Chemistry and biology connected: the development of Inscalis - p. 231 21. Chapter 13. Spiropidion discovery: Broad spectrum control of sucking insects and mites for multicrop utility - p. 241 22. Chapter 14. Discovery of oxazosulfyl: A novel broad-spectrum insecticide - p. 261 23. Chapter 15. Synthesis and biological activity of a novel insecticide, benzpyrimoxan - p. 269 24. Chapter 16. Discovery and optimization of silicon-containing complex II acaricides - p. 275 25. Chapter 17. Cycloclavine: A natural product with insecticidal potential - p. 289 26. Chapter 18. Photoresponsive pesticidal agents - p. 297 27. Chapter 19. Discovery and optimization of novel mosquitocidal compounds for the control of anopheline vectors of malaria - p. 311 28. Chapter 20. Antiparasitic dinitrile compounds for fly control in cattle - p. 325 29. Chapter 21. Design, structural derivation, and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives - p. 335 30. ADEPIDYN—the first N-methoxy-substituted carboxamide among the succinate dehydrogenase inhibitors - p. 357 31. Chapter 23. Isoflucypram—the next-generation succinate dehydrogenase inhibitor fungicide - p. 367 32. Chapter 24. Discovery and biological profile of inpyrfluxam: A new broad-spectrum succinate dehydrogenase inhibitor fungicide - p. 381 33. Chapter 25. Isofetamid: Discovery and optimization of a novel fungicide - p. 391 34. Chapter 26. Discovery of the trifluoromethyloxadiazoles—a new class of fungicides with a novel mode-of-action - p. 401 35. Chapter 27. The discovery of metyltetraprole: Reconstruction of the quinone outside inhibitor extended pharmacophore to overcome QoI-resistant strains - p. 425 36. Chapter 28. The discovery of florylpicoxamid, a new picolinamide for disease control - p. 433 37. Chapter 29. Discovery and validation of pesticide novel target: take pyruvate kinase as an example - p. 443 38. Chapter 30. Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide - p. 451 39. Chapter 31. Toward a mechanistic understanding of IGPD: A potential herbicide target - p. 459 40. Chapter 32. Isoxazolopyridines—a novel chemical cluster and a new (?) mode of action for dicot weed control - p. 469 41. Chapter 33. Quinazoline-2,4-dione: A promising scaffold for herbicide discovery - p. 483 42. Tirexor®—design of a new resistance breaking protoporphyrinogen IX oxidase inhibitor - p. 501 43. Chapter 35. Rinskor active herbicide—A new environment-friendly tool for weed management in rice and aquatic environments - p. 511 44. Chapter 36. Discovery of a novel uracil herbicide by using intermediate derivatization approach - p. 525 45. Chapter 37. Herbicidal activity and application of 1-(furan-2-yl)methylphosphonates as pyruvate dehydrogenase complex inhibitor against broadleaf weeds - p. 535 46. Chapter 38. Pesticide activities evaluation of β-carboline, dihydro-β-carboline, tetrahydro-β-carboline alkaloids, and their derivatives - p. 547 47. Chapter 39. Marine natural products and plant virus control - p. 563 48. Chapter 40. Design, synthesis, and biological evaluation of strigolactone derivatives for crop enhancement applications - p. 571 49. Chapter 41. Discovery and optimization of novel plant activators through structure-based virtual screening - p. 583 50. Index - p. 597
Recent Highlights in the Discovery and Optimization of Crop Protection Products highlights the most prominent, recent results in the search for safe and effective new crop protection products. With a focus on the design, synthesis, optimization and/or structure-activity relationships of new chemistries targeting insect, disease, weed, nematode, vector and animal parasite control, the book also includes recent developments in crop enhancement chemistries and new approaches to crop protection products. The inclusion of information on testing tools, green chemistry approaches, and the latest discovery tools, like modeling, structure-based design, and testing tools makes this volume complete.
Based on key presentations given at the 14th International IUPAC conference on Crop Protection, May 19-24, 2019 in Ghent, Belgium, this book includes the many exciting new discoveries and findings reported. It is designed to inspire additional research and advancement in the field.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. List of Contributors - p. xiii 7. About the editors - p. xxiii 8. Preface - p. xxv 9. Chapter 1. Recent innovation in crop protection research - p. 1 10. Chapter 2. Status and potential of bioprotection products for crop protection - p. 25 11. Chapter 3. Research and development of green pesticides in China - p. 39 12. Chapter 4. Agrochemical disease control: The story so far - p. 65 13. Chapter 5. Plant defense priming in the field: a review - p. 87 14. Chapter 6. Reaching beyond crop protection: Synergism between agricultural development and malaria eradication - p. 125 15. Chapter 7. Discovery and optimization of a novel insecticide, broflanilide - p. 145 16. Chapter 8. Studies on a novel insecticide, fluxametamide - p. 157 17. Chapter 9. The discovery of isocycloseram: A novel isoxazoline insecticide - p. 165 18. Chapter 10. Cyclaniliprole: A novel diamide insecticide - p. 213 19. Optimization of mesoionic pyrido[1,2-a]pyrimidinone insecticides and discovery of 3-biaryl analogs controlling Lepidoptera species - p. 221 20. Chapter 12. Chemistry and biology connected: the development of Inscalis - p. 231 21. Chapter 13. Spiropidion discovery: Broad spectrum control of sucking insects and mites for multicrop utility - p. 241 22. Chapter 14. Discovery of oxazosulfyl: A novel broad-spectrum insecticide - p. 261 23. Chapter 15. Synthesis and biological activity of a novel insecticide, benzpyrimoxan - p. 269 24. Chapter 16. Discovery and optimization of silicon-containing complex II acaricides - p. 275 25. Chapter 17. Cycloclavine: A natural product with insecticidal potential - p. 289 26. Chapter 18. Photoresponsive pesticidal agents - p. 297 27. Chapter 19. Discovery and optimization of novel mosquitocidal compounds for the control of anopheline vectors of malaria - p. 311 28. Chapter 20. Antiparasitic dinitrile compounds for fly control in cattle - p. 325 29. Chapter 21. Design, structural derivation, and nematicidal activities of 1,2,3-benzotriazin-4-one derivatives - p. 335 30. ADEPIDYN—the first N-methoxy-substituted carboxamide among the succinate dehydrogenase inhibitors - p. 357 31. Chapter 23. Isoflucypram—the next-generation succinate dehydrogenase inhibitor fungicide - p. 367 32. Chapter 24. Discovery and biological profile of inpyrfluxam: A new broad-spectrum succinate dehydrogenase inhibitor fungicide - p. 381 33. Chapter 25. Isofetamid: Discovery and optimization of a novel fungicide - p. 391 34. Chapter 26. Discovery of the trifluoromethyloxadiazoles—a new class of fungicides with a novel mode-of-action - p. 401 35. Chapter 27. The discovery of metyltetraprole: Reconstruction of the quinone outside inhibitor extended pharmacophore to overcome QoI-resistant strains - p. 425 36. Chapter 28. The discovery of florylpicoxamid, a new picolinamide for disease control - p. 433 37. Chapter 29. Discovery and validation of pesticide novel target: take pyruvate kinase as an example - p. 443 38. Chapter 30. Discovery and mode of action of cyclopyrimorate: A new paddy rice herbicide - p. 451 39. Chapter 31. Toward a mechanistic understanding of IGPD: A potential herbicide target - p. 459 40. Chapter 32. Isoxazolopyridines—a novel chemical cluster and a new (?) mode of action for dicot weed control - p. 469 41. Chapter 33. Quinazoline-2,4-dione: A promising scaffold for herbicide discovery - p. 483 42. Tirexor®—design of a new resistance breaking protoporphyrinogen IX oxidase inhibitor - p. 501 43. Chapter 35. Rinskor active herbicide—A new environment-friendly tool for weed management in rice and aquatic environments - p. 511 44. Chapter 36. Discovery of a novel uracil herbicide by using intermediate derivatization approach - p. 525 45. Chapter 37. Herbicidal activity and application of 1-(furan-2-yl)methylphosphonates as pyruvate dehydrogenase complex inhibitor against broadleaf weeds - p. 535 46. Chapter 38. Pesticide activities evaluation of β-carboline, dihydro-β-carboline, tetrahydro-β-carboline alkaloids, and their derivatives - p. 547 47. Chapter 39. Marine natural products and plant virus control - p. 563 48. Chapter 40. Design, synthesis, and biological evaluation of strigolactone derivatives for crop enhancement applications - p. 571 49. Chapter 41. Discovery and optimization of novel plant activators through structure-based virtual screening - p. 583 50. Index - p. 597
