Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies.
The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells’ role in autoimmune disease pathogenesis and therapeutic aspects.
1. Regulatory T Cells and Autoimmune Diseases - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. List of Contributors - p. xxiii 7. Foreword - p. xxxii 8. Chapter 1 Regulatory T cells and their functions in immune system - p. 3 9. Chapter 2 Regulatory T cells: mechanisms of action - p. 17 10. Chapter 3 Regulatory T cells and autoimmunity - p. 41 11. Chapter 4 Sex differences in regulatory T cells during autoimmune disease - p. 57 12. Chapter 5 Role of regulatory T cells in pathogenesis and therapeutics of systemic lupus erythematosus - p. 79 13. Chapter 6 Role of regulatory T cells in the pathogenesis and therapeutics of primary Sjögren’s syndrome - p. 95 14. Chapter 7 Role of regulatory T cells in pathogenesis and therapeutics of rheumatoid arthritis and juvenile idiopathic arthritis - p. 125 15. Chapter 8 Role of regulatory T cells in pathogenesis and therapeutics of psoriatic arthritis - p. 147 16. Chapter 9 Role of regulatory T cells in pathogenesis and therapeutics of spondyloarthritis - p. 165 17. Chapter 10 Role of regulatory T cells in pathogenesis and therapeutics of ankylosing spondylitis - p. 197 18. Chapter 11 Role of regulatory T cells in pathogenesis and therapeutics of multiple sclerosis - p. 213 19. Chapter 12 Role of regulatory T cells in the pathogenesis and therapeutics of neuromyelitis optica spectrum disorder - p. 235 20. Chapter 13 Role of regulatory T cells in pathogenesis and therapeutics of myasthenia gravis - p. 267 21. Chapter 14 Role of regulatory T cells in pathogenesis and therapeutics of Guillain–Barré syndrome and experimental autoimmune neuritis - p. 283 22. Chapter 15 Role of regulatory T cells in pathogenesis and therapeutics of chronic inflammatory demyelinating polyradiculoneuropathy - p. 303 23. Chapter 16 Role of regulatory T cells in pathogenesis and therapeutics of dermatomyositis and polymyositis - p. 325 24. Chapter 17 Role of regulatory T cells in pathogenesis and therapeutics of Crohn’s disease and ulcerative colitis - p. 351 25. Chapter 18 Role of regulatory T cells in pathogenesis and therapeutics of celiac disease - p. 387 26. Chapter 19 Role of regulatory T cells in the pathogenesis and therapeutics of autoimmune hepatitis - p. 407 27. Chapter 20 Role of regulatory T cells in pathogenesis and therapeutics of primary biliary cholangitis and primary sclerosing cholangitis - p. 433 28. Chapter 21 Role of regulatory T cells in pathogenesis and therapeutics of Hashimoto’s thyroiditis - p. 455 29. Chapter 22 Role of regulatory T cells in pathogenesis and therapeutics of Graves’ disease and Graves’ orbitopathy - p. 471 30. Chapter 23 Role of regulatory T cells in pathogenesis and therapeutics of Goodpasture’s syndrome (anti-glomerular basement membrane disease) - p. 487 31. Chapter 24 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune glomerulonephritis (IgA vasculitis and IgA nephropathy) - p. 497 32. Chapter 25 Role of regulatory T cells in pathogenesis and therapeutics of vitiligo - p. 527 33. Chapter 26 Role of regulatory T cells in pathogenesis and therapeutics of psoriasis - p. 541 34. Chapter 27 Role of regulatory T cells in pathogenesis and therapeutics of atopic dermatitis - p. 573 35. Chapter 28 Role of regulatory T cells in pathogenesis and therapeutics of alopecia areata - p. 597 36. Chapter 29 Role of regulatory T cells in pathogenesis and therapeutics of pemphigus vulgaris and bullous pemphigoid - p. 615 37. Chapter 30 Role of regulatory T cells in pathogenesis and therapeutics of scleroderma (systemic sclerosis) - p. 641 38. Chapter 31 Role of regulatory T cells in pathogenesis and therapeutics of primary antiphospholipid syndrome (Hughes syndrome) - p. 683 39. Chapter 32 Role of regulatory T cells in the pathogenesis and therapeutics of Kawasaki disease - p. 703 40. Chapter 33 Role of regulatory T cells in pathogenesis and therapeutics of Behçet disease - p. 713 41. Chapter 34 Role of regulatory T cells in pathogenesis and therapeutics of immune thrombocytopenia - p. 731 42. Chapter 35 Role of regulatory T cells in pathogenesis and treatment of antineutrophil cytoplasmic antibody-associated vasculitis - p. 755 43. Chapter 36 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune hemolytic anemia - p. 769 44. Chapter 37 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune uveitis - p. 809 45. Chapter 38 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune retinopathy - p. 817 46. Chapter 39 Role of regulatory T cells in the pathogenesis and therapeutics of type 1 diabetes mellitus - p. 823 47. Chapter 40 Vaccine-induced effects on regulatory T cell function: autoimmune perspective - p. 847 48. Chapter 41 Probiotic interventions for regulatory T cells’ induction in autoimmune diseases - p. 869 49. Chapter 42 CAR Treg-based therapeutics for autoimmune diseases - p. 883 50. Chapter 43 Current challenges and future prospects of regulatory T-cell based therapeutics in autoimmune diseases - p. 897 51. Index - p. 911 52. Index - p. 925 53. Index - p. 937
Regulatory T cells and Autoimmune Diseases addresses recent findings concerning the role of Tregs in the pathogenesis of autoimmune diseases as well as their therapeutic aspects. In particular, this book deals with the various Treg based mechanisms which can lead to autoimmune diseases and covers the different aspects of linking Tregs with autoimmune mechanisms involved in disease development by discussing animal models and human studies.
The book specifically focuses on the Treg based therapeutics and their targets to manage all known autoimmune rheumatic, central nervous system, bowel, liver, thyroid, kidney, myopathic, skin, blood & blood vessel, and eye diseases and aims to provide a must-have reference for designing therapeutic strategies to treat these autoimmune diseases. Additionally, the book covers the vaccines induced effects on functioning of Tregs and development of CAR Tregs therapy for these autoimmune diseases and concludes with current challenges and future prospects of Treg-based therapeutics. It is carefully designed to meet the requirements of both basic and advanced researchers in the area and give new dimensions and insight into the regulatory T cells’ role in autoimmune disease pathogenesis and therapeutic aspects.
1. Regulatory T Cells and Autoimmune Diseases - p. iii 2. Cover - p. iii 3. Title Page - p. iii 4. Copyright Page - p. iv 5. Table of Contents - p. iv 6. List of Contributors - p. xxiii 7. Foreword - p. xxxii 8. Chapter 1 Regulatory T cells and their functions in immune system - p. 3 9. Chapter 2 Regulatory T cells: mechanisms of action - p. 17 10. Chapter 3 Regulatory T cells and autoimmunity - p. 41 11. Chapter 4 Sex differences in regulatory T cells during autoimmune disease - p. 57 12. Chapter 5 Role of regulatory T cells in pathogenesis and therapeutics of systemic lupus erythematosus - p. 79 13. Chapter 6 Role of regulatory T cells in the pathogenesis and therapeutics of primary Sjögren’s syndrome - p. 95 14. Chapter 7 Role of regulatory T cells in pathogenesis and therapeutics of rheumatoid arthritis and juvenile idiopathic arthritis - p. 125 15. Chapter 8 Role of regulatory T cells in pathogenesis and therapeutics of psoriatic arthritis - p. 147 16. Chapter 9 Role of regulatory T cells in pathogenesis and therapeutics of spondyloarthritis - p. 165 17. Chapter 10 Role of regulatory T cells in pathogenesis and therapeutics of ankylosing spondylitis - p. 197 18. Chapter 11 Role of regulatory T cells in pathogenesis and therapeutics of multiple sclerosis - p. 213 19. Chapter 12 Role of regulatory T cells in the pathogenesis and therapeutics of neuromyelitis optica spectrum disorder - p. 235 20. Chapter 13 Role of regulatory T cells in pathogenesis and therapeutics of myasthenia gravis - p. 267 21. Chapter 14 Role of regulatory T cells in pathogenesis and therapeutics of Guillain–Barré syndrome and experimental autoimmune neuritis - p. 283 22. Chapter 15 Role of regulatory T cells in pathogenesis and therapeutics of chronic inflammatory demyelinating polyradiculoneuropathy - p. 303 23. Chapter 16 Role of regulatory T cells in pathogenesis and therapeutics of dermatomyositis and polymyositis - p. 325 24. Chapter 17 Role of regulatory T cells in pathogenesis and therapeutics of Crohn’s disease and ulcerative colitis - p. 351 25. Chapter 18 Role of regulatory T cells in pathogenesis and therapeutics of celiac disease - p. 387 26. Chapter 19 Role of regulatory T cells in the pathogenesis and therapeutics of autoimmune hepatitis - p. 407 27. Chapter 20 Role of regulatory T cells in pathogenesis and therapeutics of primary biliary cholangitis and primary sclerosing cholangitis - p. 433 28. Chapter 21 Role of regulatory T cells in pathogenesis and therapeutics of Hashimoto’s thyroiditis - p. 455 29. Chapter 22 Role of regulatory T cells in pathogenesis and therapeutics of Graves’ disease and Graves’ orbitopathy - p. 471 30. Chapter 23 Role of regulatory T cells in pathogenesis and therapeutics of Goodpasture’s syndrome (anti-glomerular basement membrane disease) - p. 487 31. Chapter 24 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune glomerulonephritis (IgA vasculitis and IgA nephropathy) - p. 497 32. Chapter 25 Role of regulatory T cells in pathogenesis and therapeutics of vitiligo - p. 527 33. Chapter 26 Role of regulatory T cells in pathogenesis and therapeutics of psoriasis - p. 541 34. Chapter 27 Role of regulatory T cells in pathogenesis and therapeutics of atopic dermatitis - p. 573 35. Chapter 28 Role of regulatory T cells in pathogenesis and therapeutics of alopecia areata - p. 597 36. Chapter 29 Role of regulatory T cells in pathogenesis and therapeutics of pemphigus vulgaris and bullous pemphigoid - p. 615 37. Chapter 30 Role of regulatory T cells in pathogenesis and therapeutics of scleroderma (systemic sclerosis) - p. 641 38. Chapter 31 Role of regulatory T cells in pathogenesis and therapeutics of primary antiphospholipid syndrome (Hughes syndrome) - p. 683 39. Chapter 32 Role of regulatory T cells in the pathogenesis and therapeutics of Kawasaki disease - p. 703 40. Chapter 33 Role of regulatory T cells in pathogenesis and therapeutics of Behçet disease - p. 713 41. Chapter 34 Role of regulatory T cells in pathogenesis and therapeutics of immune thrombocytopenia - p. 731 42. Chapter 35 Role of regulatory T cells in pathogenesis and treatment of antineutrophil cytoplasmic antibody-associated vasculitis - p. 755 43. Chapter 36 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune hemolytic anemia - p. 769 44. Chapter 37 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune uveitis - p. 809 45. Chapter 38 Role of regulatory T cells in pathogenesis and therapeutics of autoimmune retinopathy - p. 817 46. Chapter 39 Role of regulatory T cells in the pathogenesis and therapeutics of type 1 diabetes mellitus - p. 823 47. Chapter 40 Vaccine-induced effects on regulatory T cell function: autoimmune perspective - p. 847 48. Chapter 41 Probiotic interventions for regulatory T cells’ induction in autoimmune diseases - p. 869 49. Chapter 42 CAR Treg-based therapeutics for autoimmune diseases - p. 883 50. Chapter 43 Current challenges and future prospects of regulatory T-cell based therapeutics in autoimmune diseases - p. 897 51. Index - p. 911 52. Index - p. 925 53. Index - p. 937
