Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.
Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA’s efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.
Each chapter includes Learning Objectives and a “What We Learn” section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA’s efficacy in the treatment of resistant cancers.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Cover Image Legend - p. iv 7. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. vi 8. About the Series Editor - p. viii 9. Aims and Scope of the Volume - p. x 10. About the Volume Editors - p. xii 11. Preface - p. xiv 12. List of contributors - p. xvi 13. Chapter 1. Molecular structure and biological properties of all-trans retinoic acid - p. 1 14. Chapter 2. Emerging frontiers in drug development of all-trans retinoic acid and its derivatives - p. 11 15. Chapter 3. Cellular and molecular determinants of all trans retinoic acid sensitivity in different cancers - p. 39 16. Chapter 4. Apoptosis, autophagy, and unfolded protein response and their impact on all-trans retinoic acid-induced toxicity in cancer cells - p. 63 17. Chapter 5. Mechanisms of resistance to all-trans retinoic acid and use of multi-target-directed ligand to fight against resistance - p. 93 18. Chapter 6. Nanocarrier systems for targeted delivery of all-trans retinoic acid: design and mechanisms - p. 105 19. Chapter 7. Advanced delivery systems for all-trans retinoic acid: challenges and opportunities in pharmacokinetics and bioavailability - p. 125 20. Chapter 8. Mechanisms of sensitivity, resistance, and methods of delivery - p. 159 21. Chapter 9. Efficiency of all-trans retinoic acid on gastric cancer - p. 191 22. Chapter 10. All-trans retinoic acid and its role in glioblastoma therapy - p. 217 23. Chapter 11. All-trans retinoic acid and vitamin A in neurodegeneration: from oncology to neuroprotection - p. 233 24. Chapter 12. Efficiency of all-trans retinoic acid in liver cancer - p. 257 25. Chapter 13. Efficiency of all-trans retinoic acid on colon cancer - p. 307 26. Chapter 14. Retinoic acids in head and neck cancer therapy: mechanisms of sensitivity, resistance, and methods of delivery - p. 331 27. Chapter 15. Role of artificial intelligence and machine learning in predicting all-trans retinoic acid treatment outcomes - p. 355 28. Index - p. 375
Retinoic Acids in Cancer Therapy: Mechanisms of Sensitivity, Resistance, and Methods of Delivery provides an overview of how All-Trans Retinoic Acid (ATRA) kills cancer cells and how some cells survive treatment. Focusing on the cellular pathways and compartments involved in ATRA-mediated inhibition of proliferation, this book also discusses how aggressive tumors develop escape routes conferring retinoic acid resistance.
Across 15 chapters, it describes the molecular structure and biological properties of ATRA, explains mechanisms of resistance, and defines ATRA’s efficacy in seven cancer types. It concludes with chapters on ATRA and cancer stem cell biology, strategies to improve treatment, future therapeutic perspectives, and delivery methods to reduce toxicity and enhance anticancer efficacy.
Each chapter includes Learning Objectives and a “What We Learn” section, making the book highly accessible for undergraduate, graduate trainees, scientists, physicians, and biotech companies. Adding simple, attractive schemes and informative tables makes it ideal for all interested in the current status of Retinoic Acids in Cancer Therapy. This book serves as a valuable resource for health professionals, scientists, researchers, clinical practitioners, and all those seeking to broaden their knowledge and develop new drugs or therapeutic strategies to improve ATRA’s efficacy in the treatment of resistant cancers.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iii 6. Cover Image Legend - p. iv 7. Aims and Scope for Series “Cancer Sensitizing Agents for Chemotherapy” - p. vi 8. About the Series Editor - p. viii 9. Aims and Scope of the Volume - p. x 10. About the Volume Editors - p. xii 11. Preface - p. xiv 12. List of contributors - p. xvi 13. Chapter 1. Molecular structure and biological properties of all-trans retinoic acid - p. 1 14. Chapter 2. Emerging frontiers in drug development of all-trans retinoic acid and its derivatives - p. 11 15. Chapter 3. Cellular and molecular determinants of all trans retinoic acid sensitivity in different cancers - p. 39 16. Chapter 4. Apoptosis, autophagy, and unfolded protein response and their impact on all-trans retinoic acid-induced toxicity in cancer cells - p. 63 17. Chapter 5. Mechanisms of resistance to all-trans retinoic acid and use of multi-target-directed ligand to fight against resistance - p. 93 18. Chapter 6. Nanocarrier systems for targeted delivery of all-trans retinoic acid: design and mechanisms - p. 105 19. Chapter 7. Advanced delivery systems for all-trans retinoic acid: challenges and opportunities in pharmacokinetics and bioavailability - p. 125 20. Chapter 8. Mechanisms of sensitivity, resistance, and methods of delivery - p. 159 21. Chapter 9. Efficiency of all-trans retinoic acid on gastric cancer - p. 191 22. Chapter 10. All-trans retinoic acid and its role in glioblastoma therapy - p. 217 23. Chapter 11. All-trans retinoic acid and vitamin A in neurodegeneration: from oncology to neuroprotection - p. 233 24. Chapter 12. Efficiency of all-trans retinoic acid in liver cancer - p. 257 25. Chapter 13. Efficiency of all-trans retinoic acid on colon cancer - p. 307 26. Chapter 14. Retinoic acids in head and neck cancer therapy: mechanisms of sensitivity, resistance, and methods of delivery - p. 331 27. Chapter 15. Role of artificial intelligence and machine learning in predicting all-trans retinoic acid treatment outcomes - p. 355 28. Index - p. 375
