Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xvii 7. Foreword - p. xxiii 8. Preface - p. xxv 9. Chapter 1. Aging: Concept, theories, principle and future prospective - p. 1 10. Chapter 2. Overview of hallmarks of aging - p. 19 11. Chapter 3. Reverse aging: Concept, significance, theories and future prospective - p. 53 12. Chapter 4. Reprogramming a cell's epigenetic status for reverse aging - p. 63 13. Chapter 5. Cellular reprogramming for reverse aging - p. 85 14. Chapter 6. NANOG: A key element for reverse aging - p. 113 15. Chapter 7. Reduction of IGF-1/PKA to promote hematopoietic-stem cell-based reverse aging - p. 133 16. Chapter 8. Rejuvenating stem cells to reverse aging - p. 157 17. Chapter 9. Histone modification (H3K27) to reverse aging - p. 187 18. Chapter 10. Autophagy as a therapeutic target to enhance reverse aging - p. 197 19. Chapter 11. mRNA enhanced cell therapy and reverse aging - p. 211 20. Chapter 12. Reverse aging through immune driven signaling - p. 223 21. Chapter 13. Mitochondrial modulations for reverse aging - p. 251 22. Chapter 14. Reverse aging through cell cycle regulation - p. 267 23. Chapter 15. Metabolic reprogramming for reverse aging - p. 297 24. Chapter 16. Diets, phytochemicals, drugs, and nutraceuticals for reverse aging - p. 319 25. Chapter 17. Artificial intelligence and antiaging research - p. 357 26. Chapter 18. Reverse aging through redox-sensitive transcription factors modulation - p. 399 27. Index - p. 423
Reverse Aging: Current Research and Future Directions explores the integrated approach of aging and reverse aging to present a comprehensive understanding of the biological, genetic, and molecular mechanisms associated with aging. By targeting fundamental aging mechanisms, strategies are being developed to reverse and repair damage and potentially lead to greater healthspan benefits and optimal longevity. The book opens with the fundamentals of aging and how genetic, environmental, and lifestyle variables affect the biological, psychological, and social processes that lead to aging before delving into a comprehensive review of the hallmarks of aging. Next, an overview of the concept of reverse aging is presented, and subsequent chapters examine specific reverse aging models and approaches. The book explores use of cellular reprogramming techniques, provides an overview of the molecular processes that underlie NANOG-mediated reversal aging, and discusses the possible contribution of IGF-1/PKA signaling reduction to reverse aging via HSC-based therapies. The developing science of rejuvenating stems cells, histone modification, and stimulation of autophagic activity to facilitate the removal of cellular debris and reduce the impact of aging on various organ systems as well as novel concepts of mRNA enhanced cell therapy, immunological-driven signaling, mitochondrial modulations, cell-cycle regulation, and metabolic reprogramming for reserve aging are all examined. The wide range of nutritional therapies, phytochemical, prescription medications, and nutraceuticals impacting the aging process is reviewed, and the book closes with discussion of the revolutionary role AI has on anti-aging research and where the field is headed. In conclusion, the book emphasizes the importance of targeting fundamental aging mechanisms to extend health and achieve optimal longevity and provides insights into the potential implications for healthcare and aging research, highlighting the need for collaborative efforts and interdisciplinary perspectives to address the challenges of population aging and develop effective strategies for healthy aging practices.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Contributors - p. xvii 7. Foreword - p. xxiii 8. Preface - p. xxv 9. Chapter 1. Aging: Concept, theories, principle and future prospective - p. 1 10. Chapter 2. Overview of hallmarks of aging - p. 19 11. Chapter 3. Reverse aging: Concept, significance, theories and future prospective - p. 53 12. Chapter 4. Reprogramming a cell's epigenetic status for reverse aging - p. 63 13. Chapter 5. Cellular reprogramming for reverse aging - p. 85 14. Chapter 6. NANOG: A key element for reverse aging - p. 113 15. Chapter 7. Reduction of IGF-1/PKA to promote hematopoietic-stem cell-based reverse aging - p. 133 16. Chapter 8. Rejuvenating stem cells to reverse aging - p. 157 17. Chapter 9. Histone modification (H3K27) to reverse aging - p. 187 18. Chapter 10. Autophagy as a therapeutic target to enhance reverse aging - p. 197 19. Chapter 11. mRNA enhanced cell therapy and reverse aging - p. 211 20. Chapter 12. Reverse aging through immune driven signaling - p. 223 21. Chapter 13. Mitochondrial modulations for reverse aging - p. 251 22. Chapter 14. Reverse aging through cell cycle regulation - p. 267 23. Chapter 15. Metabolic reprogramming for reverse aging - p. 297 24. Chapter 16. Diets, phytochemicals, drugs, and nutraceuticals for reverse aging - p. 319 25. Chapter 17. Artificial intelligence and antiaging research - p. 357 26. Chapter 18. Reverse aging through redox-sensitive transcription factors modulation - p. 399 27. Index - p. 423
