Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of the normal kidney, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation. This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise, and readily accessible information. Academic, medical, and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
1. Introduction - p. 1849 2. Definition of metabolic acidosis - p. 1849 3. Systemic and renal acid–base homeostasis - p. 1850 4. Hepatorenal interactions - p. 1851 5. Role of the gut - p. 1852 6. Role of bone - p. 1852 7. Renal regulation of acid-base equilibrium - p. 1853 8. Determination of net acid excretion - p. 1854 9. Clinical consequences of metabolic acidosis - p. 1854 10. Metabolic and endocrine consequences of metabolic acidosis - p. 1856 11. Clinical syndromes of metabolic acidosis - p. 1865 12. Syndromes of metabolic acidosis with increased anion gap - p. 1866 13. Hyperchloremic metabolic acidosis - p. 1888 14. References - p. 1910 15. Chapter 50. Respiratory acid–base disorders - p. 1923 16. Chapter 51. Mechanisms and disorders of magnesium metabolism - p. 1941 17. Chapter 52. Calcium channels - p. 1965 18. Chapter 53. The calcium-sensing receptor - p. 1987 19. Chapter 54. Renal calcium metabolism - p. 2035 20. Chapter 55. Kidney stones - p. 2057 21. Abstract - p. 2057 22. Introduction - p. 2057 23. Epidemiology - p. 2057 24. Diagnosis - p. 2092 25. Medical treatment - p. 2093 26. References - p. 2098 27. Chapter 56. Proximal tubular handling of phosphate - p. 2123 28. Chapter 57. Clinical disturbances of phosphate homeostasis - p. 2141 29. Chapter 58. Glucose reabsorption in the kidney - p. 2181 30. Chapter 59. Kidney transport of amino acids and oligopeptides and aminoacidurias - p. 2197 31. Chapter 60. Renal filtration, transport, and metabolism of albumin and albuminuria - p. 2221 32. Section IV: Pathophysiology of renal disease - p. 2235 33. Chapter 61. Physiologic principles in the clinical evaluation of electrolyte, water, and acid–base disorders - p. 2244 34. Chapter 62. Acute kidney injury biomarkers - p. 2287 35. Chapter 63. Pathophysiology of acute kidney injury - p. 2297 36. Chapter 64. Ischemic renal disease - p. 2353 37. Chapter 65. Pathophysiology and pathogenesis of diabetic kidney disease - p. 2383 38. Chapter 66. Autosomal dominant polycystic kidney disease - p. 2409 39. Chapter 67. Renal physiology and disease in pregnancy - p. 2459 40. Abstract - p. 2459 41. Anatomical changes - p. 2459 42. Renal hemodynamics - p. 2461 43. Renal tubular function - p. 2469 44. Osmoregulation and renal water handling - p. 2471 45. Volume homeostasis - p. 2478 46. Renal disorders and gestation - p. 2482 47. Chronic kidney disease - p. 2487 48. Hypertension - p. 2495 49. References - p. 2515 50. Chapter 68. Glomerular disorders - p. 2533 51. Chapter 69. Immunologic mechanisms of vasculitis - p. 2557 52. Chapter 70. Genetic abnormalities in glomerular function - p. 2591 53. Chapter 71. Mechanisms of drug nephrotoxicity - p. 2633 54. Chapter 72. Role of proteinuria in the progression of renal disease - p. 2657 55. Chapter 73. Oxidative stress and signaling in renal physiology and kidney diseases - p. 2679 56. Chapter 74. Pathogenesis and management of disordered mineral metabolism in patients with chronic kidney disease - p. 2701 57. Chapter 75. Individualizing the dialysate to address electrolyte disturbances in the dialysis patient - p. 2731 58. Chapter 76. Mechanisms of allograft rejection - p. 2759 59. Chapter 77. Homeostasis of solute and water by the transplanted kidney - p. 2783 60. Index - p. 2831
Seldin and Giebisch’s The Kidney: Physiology and Pathophysiology, Sixth Edition provides a common language for nephrology researchers, fellows, and practicing nephrologists to discuss normal and abnormal renal physiology and the development and diagnosis of a wide range of renal diseases. Guided by a team of four distinguished authorities in nephrology, experts from all areas of renal research and practice take readers from the structure and function of the normal kidney, to the specific cellular and molecular mechanisms underlying disease development, and into the management of renal disease through physiologic regulation. This classic nephrology reference for nearly 30 years combines basic and clinical sciences that provides authoritative, concise, and readily accessible information. Academic, medical, and pharma researchers save valuable time by quickly accessing the very latest details on renal physiology and pathophysiology as opposed to searching through thousands of journal articles.
1. Introduction - p. 1849 2. Definition of metabolic acidosis - p. 1849 3. Systemic and renal acid–base homeostasis - p. 1850 4. Hepatorenal interactions - p. 1851 5. Role of the gut - p. 1852 6. Role of bone - p. 1852 7. Renal regulation of acid-base equilibrium - p. 1853 8. Determination of net acid excretion - p. 1854 9. Clinical consequences of metabolic acidosis - p. 1854 10. Metabolic and endocrine consequences of metabolic acidosis - p. 1856 11. Clinical syndromes of metabolic acidosis - p. 1865 12. Syndromes of metabolic acidosis with increased anion gap - p. 1866 13. Hyperchloremic metabolic acidosis - p. 1888 14. References - p. 1910 15. Chapter 50. Respiratory acid–base disorders - p. 1923 16. Chapter 51. Mechanisms and disorders of magnesium metabolism - p. 1941 17. Chapter 52. Calcium channels - p. 1965 18. Chapter 53. The calcium-sensing receptor - p. 1987 19. Chapter 54. Renal calcium metabolism - p. 2035 20. Chapter 55. Kidney stones - p. 2057 21. Abstract - p. 2057 22. Introduction - p. 2057 23. Epidemiology - p. 2057 24. Diagnosis - p. 2092 25. Medical treatment - p. 2093 26. References - p. 2098 27. Chapter 56. Proximal tubular handling of phosphate - p. 2123 28. Chapter 57. Clinical disturbances of phosphate homeostasis - p. 2141 29. Chapter 58. Glucose reabsorption in the kidney - p. 2181 30. Chapter 59. Kidney transport of amino acids and oligopeptides and aminoacidurias - p. 2197 31. Chapter 60. Renal filtration, transport, and metabolism of albumin and albuminuria - p. 2221 32. Section IV: Pathophysiology of renal disease - p. 2235 33. Chapter 61. Physiologic principles in the clinical evaluation of electrolyte, water, and acid–base disorders - p. 2244 34. Chapter 62. Acute kidney injury biomarkers - p. 2287 35. Chapter 63. Pathophysiology of acute kidney injury - p. 2297 36. Chapter 64. Ischemic renal disease - p. 2353 37. Chapter 65. Pathophysiology and pathogenesis of diabetic kidney disease - p. 2383 38. Chapter 66. Autosomal dominant polycystic kidney disease - p. 2409 39. Chapter 67. Renal physiology and disease in pregnancy - p. 2459 40. Abstract - p. 2459 41. Anatomical changes - p. 2459 42. Renal hemodynamics - p. 2461 43. Renal tubular function - p. 2469 44. Osmoregulation and renal water handling - p. 2471 45. Volume homeostasis - p. 2478 46. Renal disorders and gestation - p. 2482 47. Chronic kidney disease - p. 2487 48. Hypertension - p. 2495 49. References - p. 2515 50. Chapter 68. Glomerular disorders - p. 2533 51. Chapter 69. Immunologic mechanisms of vasculitis - p. 2557 52. Chapter 70. Genetic abnormalities in glomerular function - p. 2591 53. Chapter 71. Mechanisms of drug nephrotoxicity - p. 2633 54. Chapter 72. Role of proteinuria in the progression of renal disease - p. 2657 55. Chapter 73. Oxidative stress and signaling in renal physiology and kidney diseases - p. 2679 56. Chapter 74. Pathogenesis and management of disordered mineral metabolism in patients with chronic kidney disease - p. 2701 57. Chapter 75. Individualizing the dialysate to address electrolyte disturbances in the dialysis patient - p. 2731 58. Chapter 76. Mechanisms of allograft rejection - p. 2759 59. Chapter 77. Homeostasis of solute and water by the transplanted kidney - p. 2783 60. Index - p. 2831
