Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xi 8. About the editor - p. xiii 9. Preface - p. xv 10. Acknowledgment - p. xvii 11. Section I: Sirtuins and metabolic disease - p. xviii 12. Chapter 1. Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamide - p. 3 13. Chapter 2. Sirtuins in metabolic and epigenetic regulation of stem cells - p. 25 14. Chapter 3. Sirtuins and metabolic regulation: food and supplementation - p. 39 15. Chapter 4. Sirtuins in diabetes mellitus and diabetic kidney disease - p. 61 16. Chapter 5. Sirtuins and mitochondrial dysfunction - p. 79 17. Chapter 6. Sirtuins in immunometabolism - p. 91 18. Chapter 7. Mitochondrial sirtuins at the crossroads of energy metabolism and oncogenic transformation - p. 103 19. Section II: Sirtuins and cancer - p. 121 20. Chapter 8. Sirtuins and the hallmarks of cancer - p. 129 21. Chapter 9. The bifunctional roles of sirtuins and their therapeutic potential in cancer - p. 153 22. Chapter 10. Sirtuins and next generation hallmarks of cancer: cellular energetics and tumor promoting inflammation - p. 179 23. Chapter 11. Sirtuins and cellular metabolism in cancers - p. 195 24. Chapter 12. Dual role of sirtuins in cancer - p. 219 25. Chapter 13. Sirtuin signaling in hematologic malignancies - p. 233 26. Impacts of sirtuin1 and sirtuin3 on oral carcinogenesis - p. 259 27. Index - p. 275
Sirtuin Biology in Cancer and Metabolic Disease: Cellular Pathways for Clinical Discovery offers a compelling and thought-provoking perspective for the examination of the intriguing biology of sirtuins that ties cancer and metabolic disease together and provides a critical platform for the development of sirtuin-based novel therapeutic strategies to effectively treat cancer and metabolic disorders with precision in order to minimize any potentially detrimental clinical outcomes. An exciting prospect for the development of innovative therapeutics for cancer and metabolic disorders involves sirtuins. Sirtuins are histone deacetylases that have an intricate role in the onset and development of cancer and metabolic disease. Implementing a translational medicine format, this innovative reference highlights the ability of sirtuins to oversee critical pathways that involve stem cell maintenance, cellular proliferation, metabolic homeostasis, apoptosis, and autophagy that can impact cellular dysfunction and unchecked cellular growth that can occur during cancer and metabolic disease. Each chapter offers an intuitive perspective of advances on the application of sirtuin pathways for cancer and metabolic disease that will be become a "go-to" resource for a broad audience of scientists, physicians, pharmaceutical industry experts, nutritionists, and students.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Dedication - p. v 7. List of contributors - p. xi 8. About the editor - p. xiii 9. Preface - p. xv 10. Acknowledgment - p. xvii 11. Section I: Sirtuins and metabolic disease - p. xviii 12. Chapter 1. Sirtuins in metabolic disease: innovative therapeutic strategies with SIRT1, AMPK, mTOR, and nicotinamide - p. 3 13. Chapter 2. Sirtuins in metabolic and epigenetic regulation of stem cells - p. 25 14. Chapter 3. Sirtuins and metabolic regulation: food and supplementation - p. 39 15. Chapter 4. Sirtuins in diabetes mellitus and diabetic kidney disease - p. 61 16. Chapter 5. Sirtuins and mitochondrial dysfunction - p. 79 17. Chapter 6. Sirtuins in immunometabolism - p. 91 18. Chapter 7. Mitochondrial sirtuins at the crossroads of energy metabolism and oncogenic transformation - p. 103 19. Section II: Sirtuins and cancer - p. 121 20. Chapter 8. Sirtuins and the hallmarks of cancer - p. 129 21. Chapter 9. The bifunctional roles of sirtuins and their therapeutic potential in cancer - p. 153 22. Chapter 10. Sirtuins and next generation hallmarks of cancer: cellular energetics and tumor promoting inflammation - p. 179 23. Chapter 11. Sirtuins and cellular metabolism in cancers - p. 195 24. Chapter 12. Dual role of sirtuins in cancer - p. 219 25. Chapter 13. Sirtuin signaling in hematologic malignancies - p. 233 26. Impacts of sirtuin1 and sirtuin3 on oral carcinogenesis - p. 259 27. Index - p. 275
