Confidently utilize the rapidly growing selection of pharmaceuticals used to treat small animals. Small Animal Pharmacology and Therapeutics, 2nd Edition helps you understand both the therapeutic uses of common pharmaceuticals and the pharmacology behind them, giving you all of the information you need to design and modify dosing regimens, identify factors that cause drugs to fail, and anticipate adverse drug reactions.
Dosage tables help you find essential pharmaceutical information at a glance.
Multiple chapters on Antimicrobial Drugs and Antimicrobial Therapy highlight the impact of antimicrobial resistance on current practice.
1. Section 1. Introduction to Drug Use in Dogs and Cats - p. xi 2. 1. Principles of Drug Therapy - p. 1 3. 2. Factors Affecting Drug Disposition - p. 34 4. 3. Pharmacogenetics - p. 71 5. 4. Drug-Induced Diseases - p. 79 6. 5. Therapeutic Drug Monitoring - p. 112 7. Section 2. Drugs Targeting Infections or Infestations - p. 127 8. 6. Principles of Antimicrobial Therapy - p. 128 9. Judicious Antimicrobial Use - p. 128 10. Definitions and Goals - p. 129 11. Identifying the Need for Antimicrobial Therapy - p. 131 12. Identifying the Target Organism - p. 134 13. Drug Factors that Affect Antimicrobial Efficacy - p. 156 14. Microbial Factors that Affect Antimicrobial Efficacy - p. 161 15. Host Factors that Affect Antimicrobial Efficacy - p. 168 16. Drug Factors that Affect Antimicrobial Efficacy - p. 171 17. Enhancing Antimicrobial Efficacy - p. 176 18. Antimicrobial Prophylaxis - p. 180 19. Surgical Prophylaxis - p. 180 20. 7. Antimicrobial Drugs - p. 189 21. Drugs that Target the Cell Wall - p. 196 22. Drugs that Target Ribosomes (Bactericidal) - p. 222 23. Drugs that Target Nucleic Acids - p. 231 24. Drugs that Target Folic Acid - p. 247 25. Drugs that Target Ribosomes (Bacteriostatic) - p. 251 26. Miscellaneous Antimicrobials - p. 260 27. 8. Treatment of Bacterial Infections - p. 270 28. Infections of the Central Nervous System and Special Senses - p. 271 29. Infections of the Skin - p. 286 30. Infections of the Musculoskeletal System - p. 301 31. Urinary Tract Infections (UTIs) - p. 306 32. Infections of the Uterus - p. 321 33. Respiratory Tract Infections - p. 322 34. Infections of the Gastrointestinal Tract - p. 330 35. Infections Associated with Bacteremia - p. 332 36. Anaerobic Infections - p. 342 37. Selected Anaerobic Infections - p. 345 38. Miscellaneous Infections - p. 348 39. Rickettsial and Anaplasmid Diseases - p. 354 40. 9. Treatment of Fungal Infections - p. 364 41. 10. Antiviral Therapy - p. 398 42. 11. Disinfectants, Antiseptics, and Related Biocides - p. 425 43. 12. Drugs for the Treatment of Protozoal Infections - p. 434 44. 13. Drugs for the Treatment of Helminth Infections: Anthelmintics - p. 451 45. Section 3. Drugs Targeting Body Systems - p. 468 46. 14. Therapy of Cardiovascular Diseases - p. 469 47. Cardiovascular Physiology as it Pertains to Cardiovascular Drugs - p. 469 48. Pathophysiology of Cardiac Disease as it Relates to Drug Therapy: Congestive Heart Failure - p. 480 49. Vasodilator Therapy - p. 482 50. Angiotensin-Converting Enzyme Inhibitors and Treatment of Progressive Renal Disease - p. 499 51. Angiotensin-Converting Enzyme Inhibitors and Treatment of Proteinuria - p. 501 52. Antiarrhythmic Drugs - p. 504 53. Positive Inotropes - p. 519 54. Negative Inotropes - p. 529 55. Treatment of Specific Vascular Disorders - p. 529 56. Hyperthermia - p. 542 57. Shock - p. 542 58. Hyperlipidemia - p. 548 59. Heartworm Disease (Dirofilariasis) - p. 552 60. 15. Drugs Acting on Blood or Blood-Forming Organs - p. 568 61. 16. Fluids, Electrolytes, and Acid–Base Therapy - p. 599 62. 17. Drugs Affecting Urine Formation - p. 624 63. 18. Treatment of Urinary Disorders - p. 640 64. 19. Gastrointestinal Pharmacology - p. 672 65. Drugs that Target Appetite or Caloric Balance - p. 672 66. Appetite Stimulants - p. 675 67. Appetite Suppressants and Anti-Obesity Drugs - p. 684 68. Emetics and Antiemetics - p. 686 69. Antiulcer Drugs - p. 692 70. Modulators of Gastrointestinal Motility - p. 700 71. Drugs Affecting the Intestinal Tract - p. 705 72. Gastrointestinal Protectants and Absorbents - p. 707 73. Laxatives and Cathartics - p. 708 74. Agents Promoting Gastrointestinal Functions - p. 710 75. Biotherapeutics: Prebiotics, Probiotics, and Synbiotics - p. 710 76. Drugs Affecting the Liver - p. 716 77. Treatment of Specific (Non-Infective) Disorders of the Gastrointestinal Tract - p. 720 78. Vomiting - p. 723 79. Portosystemic Shunting - p. 736 80. 20. Drugs Affecting the Respiratory System - p. 745 81. 21. Drug Therapy for Endocrinopathies - p. 783 82. Diseases of the Thyroid Gland - p. 783 83. Diseases of the Parathyroid Glands - p. 795 84. Diseases of the Pancreas: Diabetes Mellitus - p. 801 85. Diseases of the Adrenal Glands - p. 818 86. Disorders of the Pituitary Gland - p. 835 87. 22. Dermatologic Therapy - p. 848 88. 23. Rational Use of Reproductive Hormones - p. 871 89. Section 4. Drugs Acting on the Nervous System - p. 886 90. 24. Anesthetic Agents - p. 887 91. 25. Muscle Relaxants - p. 894 92. 26. Drugs That Modify Animal Behavior - p. 903 93. 27. Anticonvulsants and Other Neurologic Therapies in Small Animals - p. 932 94. Physiology and Seizure Pathophysiology - p. 933 95. Principles of Anticonvulsant Therapy - p. 939 96. Pharmacokinetic Considerations - p. 940 97. Safety - p. 947 98. Drug Interactions - p. 947 99. Therapeutic Drug Monitoring - p. 948 100. Anticonvulsant Drugs - p. 950 101. Acute Management of Seizures - p. 973 102. Chronic Control of Seizures - p. 974 103. Drugs Contraindicated for Epileptic Patients - p. 976 104. Treatment of Other Neurologic Conditions - p. 977 105. Ocular Pharmacology - p. 983 106. 28. Control of Pain in Small Animals: Opioid Agonists and Antagonists and Other Locally and Centrally Acting Analgesics - p. 994 107. Definition of Pain and its Recognition - p. 994 108. Pharmacologic Control of Pain - p. 998 109. Control of Pain - p. 998 110. Opiates - p. 1005 111. Powerful Pure Agonists - p. 1012 112. Mild to Moderate Pure Agonists - p. 1022 113. Mixed Agonists and Antagonists - p. 1023 114. Narcotic Antagonists - p. 1025 115. Therapeutic use of Opioid Analgesics - p. 1026 116. Other Centrally Acting Drugs - p. 1027 117. Anticonvulsants and Behavior-Modifying Drugs - p. 1030 118. Local Anesthetics - p. 1031 119. Miscellaneous Agents - p. 1034 120. Special Considerations for Control of Pain in Animals - p. 1034 121. Section 5. Drugs Targeting Infl ammation or Immunomodulation - p. 1044 122. 29. Antiinflammatory Drugs - p. 1045 123. The Pathophysiology of Inflammation - p. 1045 124. The Role of Chemical Mediators in the Inflammatory Response - p. 1046 125. Shared Pharmacology of Nonsteroidal Antiinflammatory Drugs - p. 1050 126. Conventional Nonsteroidal Antiinflammatory Drugs - p. 1072 127. Cyclooxygenase-1–Sparing Nonsteroidal Antiinflammatory Drugs - p. 1076 128. Cyclooxygenase-1–Sparing Drugs Approved For Use In Human Medicine - p. 1083 129. Miscellaneous Nonsteroidal Antiinflammatory Drugs - p. 1084 130. Treatment of Osteoarthritis - p. 1091 131. Disease-Modifying Agents: Chondroprotectants - p. 1094 132. Other Antiinflammatory Drugs - p. 1102 133. Use of Modulators of Inflammation in the Treatment of Shock and Central Nervous System Trauma - p. 1104 134. 30. Glucocorticoids and Mineralocorticoids - p. 1119 135. 31. Immunomodulators or Biological Response Modifiers: Introduction and Miscellaneous Agents - p. 1150 136. The Immune Response - p. 1150 137. Classification of Immunomodulatory Drugs - p. 1159 138. Immunomodulation in Viral and Neoplastic Diseases - p. 1159 139. Immunomodifying Drugs - p. 1160 140. Treatment of Specific Immune-Mediated Diseases - p. 1182 141. 32. Biologic Response Modifiers: Interferons, Interleukins, Chemokines, and Hematopoietic Growth Factors - p. 1193 142. 33. Chemotherapy - p. 1210 143. Appendices - p. 1235 144. Appendix 1. Regulatory Issues - p. 1236 145. Appendix 2. Conversions, Equivalents, and Abbreviations - p. 1251 146. Appendix 3. Sample Pharmaceutical Calculations - p. 1255 147. Appendix 4. Nutrition and Pharmacology - p. 1258 148. Appendix 5. Clinical Toxicology - p. 1261 149. Appendix 6. Generic and Trade Names∗ - p. 1275 150. Appendix 7 - p. 1290
Confidently utilize the rapidly growing selection of pharmaceuticals used to treat small animals. Small Animal Pharmacology and Therapeutics, 2nd Edition helps you understand both the therapeutic uses of common pharmaceuticals and the pharmacology behind them, giving you all of the information you need to design and modify dosing regimens, identify factors that cause drugs to fail, and anticipate adverse drug reactions.
Dosage tables help you find essential pharmaceutical information at a glance.
Multiple chapters on Antimicrobial Drugs and Antimicrobial Therapy highlight the impact of antimicrobial resistance on current practice.
1. Section 1. Introduction to Drug Use in Dogs and Cats - p. xi 2. 1. Principles of Drug Therapy - p. 1 3. 2. Factors Affecting Drug Disposition - p. 34 4. 3. Pharmacogenetics - p. 71 5. 4. Drug-Induced Diseases - p. 79 6. 5. Therapeutic Drug Monitoring - p. 112 7. Section 2. Drugs Targeting Infections or Infestations - p. 127 8. 6. Principles of Antimicrobial Therapy - p. 128 9. Judicious Antimicrobial Use - p. 128 10. Definitions and Goals - p. 129 11. Identifying the Need for Antimicrobial Therapy - p. 131 12. Identifying the Target Organism - p. 134 13. Drug Factors that Affect Antimicrobial Efficacy - p. 156 14. Microbial Factors that Affect Antimicrobial Efficacy - p. 161 15. Host Factors that Affect Antimicrobial Efficacy - p. 168 16. Drug Factors that Affect Antimicrobial Efficacy - p. 171 17. Enhancing Antimicrobial Efficacy - p. 176 18. Antimicrobial Prophylaxis - p. 180 19. Surgical Prophylaxis - p. 180 20. 7. Antimicrobial Drugs - p. 189 21. Drugs that Target the Cell Wall - p. 196 22. Drugs that Target Ribosomes (Bactericidal) - p. 222 23. Drugs that Target Nucleic Acids - p. 231 24. Drugs that Target Folic Acid - p. 247 25. Drugs that Target Ribosomes (Bacteriostatic) - p. 251 26. Miscellaneous Antimicrobials - p. 260 27. 8. Treatment of Bacterial Infections - p. 270 28. Infections of the Central Nervous System and Special Senses - p. 271 29. Infections of the Skin - p. 286 30. Infections of the Musculoskeletal System - p. 301 31. Urinary Tract Infections (UTIs) - p. 306 32. Infections of the Uterus - p. 321 33. Respiratory Tract Infections - p. 322 34. Infections of the Gastrointestinal Tract - p. 330 35. Infections Associated with Bacteremia - p. 332 36. Anaerobic Infections - p. 342 37. Selected Anaerobic Infections - p. 345 38. Miscellaneous Infections - p. 348 39. Rickettsial and Anaplasmid Diseases - p. 354 40. 9. Treatment of Fungal Infections - p. 364 41. 10. Antiviral Therapy - p. 398 42. 11. Disinfectants, Antiseptics, and Related Biocides - p. 425 43. 12. Drugs for the Treatment of Protozoal Infections - p. 434 44. 13. Drugs for the Treatment of Helminth Infections: Anthelmintics - p. 451 45. Section 3. Drugs Targeting Body Systems - p. 468 46. 14. Therapy of Cardiovascular Diseases - p. 469 47. Cardiovascular Physiology as it Pertains to Cardiovascular Drugs - p. 469 48. Pathophysiology of Cardiac Disease as it Relates to Drug Therapy: Congestive Heart Failure - p. 480 49. Vasodilator Therapy - p. 482 50. Angiotensin-Converting Enzyme Inhibitors and Treatment of Progressive Renal Disease - p. 499 51. Angiotensin-Converting Enzyme Inhibitors and Treatment of Proteinuria - p. 501 52. Antiarrhythmic Drugs - p. 504 53. Positive Inotropes - p. 519 54. Negative Inotropes - p. 529 55. Treatment of Specific Vascular Disorders - p. 529 56. Hyperthermia - p. 542 57. Shock - p. 542 58. Hyperlipidemia - p. 548 59. Heartworm Disease (Dirofilariasis) - p. 552 60. 15. Drugs Acting on Blood or Blood-Forming Organs - p. 568 61. 16. Fluids, Electrolytes, and Acid–Base Therapy - p. 599 62. 17. Drugs Affecting Urine Formation - p. 624 63. 18. Treatment of Urinary Disorders - p. 640 64. 19. Gastrointestinal Pharmacology - p. 672 65. Drugs that Target Appetite or Caloric Balance - p. 672 66. Appetite Stimulants - p. 675 67. Appetite Suppressants and Anti-Obesity Drugs - p. 684 68. Emetics and Antiemetics - p. 686 69. Antiulcer Drugs - p. 692 70. Modulators of Gastrointestinal Motility - p. 700 71. Drugs Affecting the Intestinal Tract - p. 705 72. Gastrointestinal Protectants and Absorbents - p. 707 73. Laxatives and Cathartics - p. 708 74. Agents Promoting Gastrointestinal Functions - p. 710 75. Biotherapeutics: Prebiotics, Probiotics, and Synbiotics - p. 710 76. Drugs Affecting the Liver - p. 716 77. Treatment of Specific (Non-Infective) Disorders of the Gastrointestinal Tract - p. 720 78. Vomiting - p. 723 79. Portosystemic Shunting - p. 736 80. 20. Drugs Affecting the Respiratory System - p. 745 81. 21. Drug Therapy for Endocrinopathies - p. 783 82. Diseases of the Thyroid Gland - p. 783 83. Diseases of the Parathyroid Glands - p. 795 84. Diseases of the Pancreas: Diabetes Mellitus - p. 801 85. Diseases of the Adrenal Glands - p. 818 86. Disorders of the Pituitary Gland - p. 835 87. 22. Dermatologic Therapy - p. 848 88. 23. Rational Use of Reproductive Hormones - p. 871 89. Section 4. Drugs Acting on the Nervous System - p. 886 90. 24. Anesthetic Agents - p. 887 91. 25. Muscle Relaxants - p. 894 92. 26. Drugs That Modify Animal Behavior - p. 903 93. 27. Anticonvulsants and Other Neurologic Therapies in Small Animals - p. 932 94. Physiology and Seizure Pathophysiology - p. 933 95. Principles of Anticonvulsant Therapy - p. 939 96. Pharmacokinetic Considerations - p. 940 97. Safety - p. 947 98. Drug Interactions - p. 947 99. Therapeutic Drug Monitoring - p. 948 100. Anticonvulsant Drugs - p. 950 101. Acute Management of Seizures - p. 973 102. Chronic Control of Seizures - p. 974 103. Drugs Contraindicated for Epileptic Patients - p. 976 104. Treatment of Other Neurologic Conditions - p. 977 105. Ocular Pharmacology - p. 983 106. 28. Control of Pain in Small Animals: Opioid Agonists and Antagonists and Other Locally and Centrally Acting Analgesics - p. 994 107. Definition of Pain and its Recognition - p. 994 108. Pharmacologic Control of Pain - p. 998 109. Control of Pain - p. 998 110. Opiates - p. 1005 111. Powerful Pure Agonists - p. 1012 112. Mild to Moderate Pure Agonists - p. 1022 113. Mixed Agonists and Antagonists - p. 1023 114. Narcotic Antagonists - p. 1025 115. Therapeutic use of Opioid Analgesics - p. 1026 116. Other Centrally Acting Drugs - p. 1027 117. Anticonvulsants and Behavior-Modifying Drugs - p. 1030 118. Local Anesthetics - p. 1031 119. Miscellaneous Agents - p. 1034 120. Special Considerations for Control of Pain in Animals - p. 1034 121. Section 5. Drugs Targeting Infl ammation or Immunomodulation - p. 1044 122. 29. Antiinflammatory Drugs - p. 1045 123. The Pathophysiology of Inflammation - p. 1045 124. The Role of Chemical Mediators in the Inflammatory Response - p. 1046 125. Shared Pharmacology of Nonsteroidal Antiinflammatory Drugs - p. 1050 126. Conventional Nonsteroidal Antiinflammatory Drugs - p. 1072 127. Cyclooxygenase-1–Sparing Nonsteroidal Antiinflammatory Drugs - p. 1076 128. Cyclooxygenase-1–Sparing Drugs Approved For Use In Human Medicine - p. 1083 129. Miscellaneous Nonsteroidal Antiinflammatory Drugs - p. 1084 130. Treatment of Osteoarthritis - p. 1091 131. Disease-Modifying Agents: Chondroprotectants - p. 1094 132. Other Antiinflammatory Drugs - p. 1102 133. Use of Modulators of Inflammation in the Treatment of Shock and Central Nervous System Trauma - p. 1104 134. 30. Glucocorticoids and Mineralocorticoids - p. 1119 135. 31. Immunomodulators or Biological Response Modifiers: Introduction and Miscellaneous Agents - p. 1150 136. The Immune Response - p. 1150 137. Classification of Immunomodulatory Drugs - p. 1159 138. Immunomodulation in Viral and Neoplastic Diseases - p. 1159 139. Immunomodifying Drugs - p. 1160 140. Treatment of Specific Immune-Mediated Diseases - p. 1182 141. 32. Biologic Response Modifiers: Interferons, Interleukins, Chemokines, and Hematopoietic Growth Factors - p. 1193 142. 33. Chemotherapy - p. 1210 143. Appendices - p. 1235 144. Appendix 1. Regulatory Issues - p. 1236 145. Appendix 2. Conversions, Equivalents, and Abbreviations - p. 1251 146. Appendix 3. Sample Pharmaceutical Calculations - p. 1255 147. Appendix 4. Nutrition and Pharmacology - p. 1258 148. Appendix 5. Clinical Toxicology - p. 1261 149. Appendix 6. Generic and Trade Names∗ - p. 1275 150. Appendix 7 - p. 1290
