Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach introduces retrosynthetic analysis through strategic disconnection methods. It prioritizes disconnections of general structures characterized by specific functionalization patterns or structural motifs like stereogenic centers or bicyclic frameworks. Numerous examples from carefully selected literature illustrate each strategic disconnection, organized by functional or structural pattern, selected disconnection, and polar, radical, or concerted reaction pathways. Developing a deep understanding of these examples enhances 3D visualization skills, critical reasoning, and expertise in synthetic strategies.
The book offers insights into advancements in organic synthesis over the last 50 years, with cases of varying complexity from curated literature. Readers can focus on examples that align with their interests or lab work, each case referenced for easy access to primary information. It is ideal for graduate and postdoc students in organic chemistry and synthesis and researchers in industry. Advanced undergraduate students with a solid organic chemistry foundation may also find it beneficial.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Preface - p. vii 7. List of abbreviations - p. ix 8. Chapter 1. Chemical synthesis as design and construction of molecular architectures: a brief history - p. 1 9. Chapter 2. Organic synthesis: basic concepts, definitions, classification of synthetic steps, and retrosynthetic analysis - p. 33 10. Chapter 3. One-group disconnections: alkanes, ethers, thioethers, secondary and tertiary amines - p. 91 11. Chapter 4. One-group disconnections: target molecules containing one carbon-heteroatom single or multiple bond - p. 143 12. Chapter 5. One-group disconnections: target molecules containing one carbon–carbon multiple bond - p. 219 13. Chapter 6. Two-group disconnections: bifunctional compounds containing two carbon-heteroatom bonds, characterized by a Functionality Span of 3 - p. 311 14. Chapter 7. Two-group disconnections: bifunctional compounds containing two carbon-heteroatom bonds with functionality span values of 2, 4, and 5 - p. 379 15. Chapter 8. Two-group disconnections: bifunctional compounds containing two carbon–carbon multiple bonds (dienes, diynes, and enynes) - p. 439 16. Chapter 9. Two-group disconnections: bifunctional compounds containing both one carbon-heteroatom bond and one carbon–carbon multiple bond (enones, unsaturated alcohols, etc.) - p. 491 17. Chapter 10. Structural pattern recognition in retrosynthetic analysis - p. 551 18. Chapter 11. Ring-guided retrosynthetic analysis of cyclic compounds - p. 609 19. Chapter 12. Synthesis of optically active target molecules - p. 703 20. Chapter 13. One-pot multistep reactions - p. 761 21. Chapter 14. Organic synthesis in the 21st century - p. 803 22. Index - p. 825
Strategic Disconnections in Retrosynthetic Analysis from Pattern Recognition: An Applied Approach introduces retrosynthetic analysis through strategic disconnection methods. It prioritizes disconnections of general structures characterized by specific functionalization patterns or structural motifs like stereogenic centers or bicyclic frameworks. Numerous examples from carefully selected literature illustrate each strategic disconnection, organized by functional or structural pattern, selected disconnection, and polar, radical, or concerted reaction pathways. Developing a deep understanding of these examples enhances 3D visualization skills, critical reasoning, and expertise in synthetic strategies.
The book offers insights into advancements in organic synthesis over the last 50 years, with cases of varying complexity from curated literature. Readers can focus on examples that align with their interests or lab work, each case referenced for easy access to primary information. It is ideal for graduate and postdoc students in organic chemistry and synthesis and researchers in industry. Advanced undergraduate students with a solid organic chemistry foundation may also find it beneficial.
1. Title of Book - p. i 2. Cover image - p. i 3. Title page - p. ii 4. Table of Contents - p. iii 5. Copyright - p. iv 6. Preface - p. vii 7. List of abbreviations - p. ix 8. Chapter 1. Chemical synthesis as design and construction of molecular architectures: a brief history - p. 1 9. Chapter 2. Organic synthesis: basic concepts, definitions, classification of synthetic steps, and retrosynthetic analysis - p. 33 10. Chapter 3. One-group disconnections: alkanes, ethers, thioethers, secondary and tertiary amines - p. 91 11. Chapter 4. One-group disconnections: target molecules containing one carbon-heteroatom single or multiple bond - p. 143 12. Chapter 5. One-group disconnections: target molecules containing one carbon–carbon multiple bond - p. 219 13. Chapter 6. Two-group disconnections: bifunctional compounds containing two carbon-heteroatom bonds, characterized by a Functionality Span of 3 - p. 311 14. Chapter 7. Two-group disconnections: bifunctional compounds containing two carbon-heteroatom bonds with functionality span values of 2, 4, and 5 - p. 379 15. Chapter 8. Two-group disconnections: bifunctional compounds containing two carbon–carbon multiple bonds (dienes, diynes, and enynes) - p. 439 16. Chapter 9. Two-group disconnections: bifunctional compounds containing both one carbon-heteroatom bond and one carbon–carbon multiple bond (enones, unsaturated alcohols, etc.) - p. 491 17. Chapter 10. Structural pattern recognition in retrosynthetic analysis - p. 551 18. Chapter 11. Ring-guided retrosynthetic analysis of cyclic compounds - p. 609 19. Chapter 12. Synthesis of optically active target molecules - p. 703 20. Chapter 13. One-pot multistep reactions - p. 761 21. Chapter 14. Organic synthesis in the 21st century - p. 803 22. Index - p. 825
