Authored by the world’s foremost stroke experts, this classic text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. Stroke: Pathophysiology, Diagnosis, and Management, 7th Edition, covers every aspect of this fast-moving field, and is an ideal resource for stroke specialists, general neurologists, and other medical professionals with an interest in stroke. You’ll find expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, advances in diagnostic tests, full-color CT images, pathology slides, and much more, for a complete picture of today’s stroke medicine.
1. Chapter 1: Introduction - p. iii 2. Chapter 2: Cerebral Vascular Biology in Health and Disease - p. iii 3. Chapter 3: Mechanisms of Thrombosis and Thrombolysis - p. g10 4. Chapter 4: Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease - p. g22 5. Chapter 5: Histopathology of Brain Tissue Response to Stroke and Injury - p. g40 6. Chapter 6: Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death - p. g56 7. Chapter 7: Intracellular Signaling: Mediators and Protective Responses - p. g73 8. Chapter 8: The Neurovascular Unit and Responses to Ischemia - p. g81 9. Chapter 9: Mechanisms of Damage After Cerebral Hemorrhage - p. g90 10. Chapter 10: White Matter Pathophysiology - p. g100 11. Chapter 11: Inflammation and Immune Response - p. g115 12. Chapter 12: Mechanisms of Plasticity Remodeling and Recovery - p. g127 13. Chapter 13: Genetics and Vascular Biology of Brain Vascular Malformations - p. g136 14. Chapter 14: Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and Dementia - p. g148 15. Section II: Epidemiology and Risk Factors - p. g159 16. Chapter 15: Introduction - p. g159 17. Chapter 16: Global Burden of Stroke - p. g159 18. Chapter 17: Stroke Disparities - p. g177 19. Chapter 18: Risk Factors and Prevention - p. g186 20. Chapter 19: Prognosis After Stroke - p. g205 21. Chapter 20: Vascular Dementia and Cognitive Impairment - p. g220 22. Chapter 21: Genetic Basis of Stroke Occurrence, Prevention, and Outcome - p. g233 23. Section III: Clinical Manifestations - p. g246 24. Chapter 22: Introduction - p. g246 25. Chapter 23: Classification of Ischemic Stroke - p. g246 26. Chapter 24: Clinical Scales to Assess Patients With Stroke - p. g260 27. Chapter 25: Carotid Artery Disease - p. g278 28. Chapter 26: Anterior Cerebral Artery Disease - p. g298 29. Chapter 27: Middle Cerebral Artery Disease - p. g314 30. Chapter 28: Posterior Cerebral Artery Disease - p. g344 31. Chapter 29: Vertebrobasilar Disease - p. g364 32. Chapter 30: Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-Vessel Disease - p. g401 33. Chapter 31: Intracerebral Hemorrhage - p. g418 34. Chapter 32: Aneurysmal Subarachnoid Hemorrhage - p. g427 35. Chapter 33: Arteriovenous Malformations and Other Vascular Anomalies - p. g446 36. Chapter 34: Stroke and Other Vascular Syndromes of the Spinal Cord - p. g465 37. Section IV: Specific Conditions and Stroke - p. g474 38. Chapter 35: Introduction - p. g474 39. Chapter 36: Cardiac Diseases - p. g474 40. Chapter 37: Atherosclerotic Disease of the Proximal Aorta - p. g487 41. Chapter 38: Stroke Related to Surgery and Other Procedures - p. g500 42. Chapter 39: Arterial Dissection, Fibromuscular Dysplasia, and Carotid Webs - p. g506 43. Chapter 40: Inflammatory and Infectious Vasculopathies - p. g527 44. Chapter 41: Reversible Cerebral Vasoconstriction Syndromes - p. g544 45. Chapter 42: Posterior Reversible Encephalopathy Syndrome - p. g552 46. Chapter 43: Stroke and Substance Abuse - p. g562 47. Chapter 44: Moyamoya Disease - p. g571 48. Chapter 45: Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy - p. g585 49. Chapter 46: Hematologic Disorders and Stroke - p. g590 50. Chapter 47: Migraine and Stroke - p. g603 51. Chapter 48: Cryptogenic Stroke - p. g613 52. Chapter 49: Cerebral Venous Thrombosis - p. g622 53. Section V: Diagnostic Studies - p. g636 54. Chapter 50: Introduction - p. g636 55. Chapter 51: Ultrasonography - p. g636 56. Chapter 52: Computed Tomography-Based Evaluation of Cerebrovascular Disease - p. g658 57. Chapter 53: Magnetic Resonance Imaging of Cerebrovascular Diseases - p. g674 58. Chapter 54: Cerebral Angiography - p. g695 59. Chapter 55: OMICs in Stroke: Insight Into Stroke Through Epigenomics, Transcriptomics, Proteomics, Lipidomics, and Metabolomics - p. g713 60. Section VI: Therapy - p. g721 61. Part A: Medical Therapy - p. g721 62. Chapter 56: Introduction - p. g721 63. Chapter 57: Stroke Systems of Care and Impact on Acute Stroke Treatment - p. g721 64. Chapter 58: Prehospital and Emergency Department Care of the Patient With Acute Stroke - p. g733 65. Chapter 59: Intravenous Thrombolysis - p. g748 66. Chapter 60: Antithrombotic Therapy for Treatment of Acute Ischemic Stroke - p. g771 67. Chapter 61: General Stroke Management and Stroke Units - p. g785 68. Chapter 62: Critical Care of the Patient With Acute Stroke - p. g799 69. Chapter 63: Pharmacologic Modification of Acute Cerebral Ischemia - p. g827 70. Chapter 64: Treatment of “Other” Stroke Etiologies - p. g848 71. Chapter 65: Medical Therapy of Intracerebral and Intraventricular Hemorrhage - p. g865 72. Chapter 66: Rehabilitation and Recovery of the Patient With Stroke - p. g877 73. Chapter 67: Interventions to Improve Recovery After Stroke - p. g887 74. Chapter 68: Enhancing Stroke Recovery With Cellular Therapies - p. g898 75. Chapter 69: Antiplatelet Therapy for Secondary Prevention of Stroke - p. g910 76. Chapter 70: Secondary Prevention of Cardioembolic Stroke - p. g930 77. Chapter 71: Design of Stroke-Related Clinical Trials - p. g942 78. Part B: Interventional Therapy - p. g954 79. Chapter 72: Introduction - p. g954 80. Chapter 73: Endovascular Therapy of Extracranial and Intracranial Occlusive Disease - p. g954 81. Chapter 74: Endovascular Treatment of Acute Ischemic Stroke - p. g969 82. Chapter 75: Endovascular Treatment of Intracranial Aneurysms - p. g983 83. Chapter 76: Interventional Therapy of Brain and Spinal Arteriovenous Malformations - p. g999 84. Chapter 77: Dural Arteriovenous Malformations - p. g1015 85. Part C: Surgical Therapy - p. g1026 86. Chapter 78: Introduction - p. g1026 87. Chapter 79: Surgery of Anterior and Posterior Aneurysms - p. g1026 88. Chapter 80: Surgery for Intracerebral Hemorrhage - p. g1046 89. Chapter 81: Management of Intraventricular Hemorrhage - p. g1053 90. Chapter 82: Surgical Management of Cranial and Spinal Arteriovenous Malformations - p. g1064 91. Chapter 83: Surgical Management of Cavernous Malformations and Venous Anomalies - p. g1076 92. Chapter 84: Indications for Carotid Endarterectomy in Patients With Asymptomatic and Symptomatic Carotid Stenosis - p. g1083 93. Chapter 85: Extracranial–Intracranial Bypass for Cerebral Ischemia - p. g1089 94. Chapter 86: Decompressive Craniectomy for Infarction and Intracranial Hemorrhages - p. g1098 95. Index - p. g1111
Authored by the world’s foremost stroke experts, this classic text brings you fully up to date with current research findings and management approaches for cerebrovascular disease. Stroke: Pathophysiology, Diagnosis, and Management, 7th Edition, covers every aspect of this fast-moving field, and is an ideal resource for stroke specialists, general neurologists, and other medical professionals with an interest in stroke. You’ll find expert clinical guidance, comprehensive pathophysiology coverage, data from recent trials, advances in diagnostic tests, full-color CT images, pathology slides, and much more, for a complete picture of today’s stroke medicine.
1. Chapter 1: Introduction - p. iii 2. Chapter 2: Cerebral Vascular Biology in Health and Disease - p. iii 3. Chapter 3: Mechanisms of Thrombosis and Thrombolysis - p. g10 4. Chapter 4: Cerebral Blood Flow and Metabolism: Regulation and Pathophysiology in Cerebrovascular Disease - p. g22 5. Chapter 5: Histopathology of Brain Tissue Response to Stroke and Injury - p. g40 6. Chapter 6: Molecular and Cellular Mechanisms of Ischemia-Induced Neuronal Death - p. g56 7. Chapter 7: Intracellular Signaling: Mediators and Protective Responses - p. g73 8. Chapter 8: The Neurovascular Unit and Responses to Ischemia - p. g81 9. Chapter 9: Mechanisms of Damage After Cerebral Hemorrhage - p. g90 10. Chapter 10: White Matter Pathophysiology - p. g100 11. Chapter 11: Inflammation and Immune Response - p. g115 12. Chapter 12: Mechanisms of Plasticity Remodeling and Recovery - p. g127 13. Chapter 13: Genetics and Vascular Biology of Brain Vascular Malformations - p. g136 14. Chapter 14: Gliovascular Mechanisms and White Matter Injury in Vascular Cognitive Impairment and Dementia - p. g148 15. Section II: Epidemiology and Risk Factors - p. g159 16. Chapter 15: Introduction - p. g159 17. Chapter 16: Global Burden of Stroke - p. g159 18. Chapter 17: Stroke Disparities - p. g177 19. Chapter 18: Risk Factors and Prevention - p. g186 20. Chapter 19: Prognosis After Stroke - p. g205 21. Chapter 20: Vascular Dementia and Cognitive Impairment - p. g220 22. Chapter 21: Genetic Basis of Stroke Occurrence, Prevention, and Outcome - p. g233 23. Section III: Clinical Manifestations - p. g246 24. Chapter 22: Introduction - p. g246 25. Chapter 23: Classification of Ischemic Stroke - p. g246 26. Chapter 24: Clinical Scales to Assess Patients With Stroke - p. g260 27. Chapter 25: Carotid Artery Disease - p. g278 28. Chapter 26: Anterior Cerebral Artery Disease - p. g298 29. Chapter 27: Middle Cerebral Artery Disease - p. g314 30. Chapter 28: Posterior Cerebral Artery Disease - p. g344 31. Chapter 29: Vertebrobasilar Disease - p. g364 32. Chapter 30: Lacunar Syndromes, Lacunar Infarcts, and Cerebral Small-Vessel Disease - p. g401 33. Chapter 31: Intracerebral Hemorrhage - p. g418 34. Chapter 32: Aneurysmal Subarachnoid Hemorrhage - p. g427 35. Chapter 33: Arteriovenous Malformations and Other Vascular Anomalies - p. g446 36. Chapter 34: Stroke and Other Vascular Syndromes of the Spinal Cord - p. g465 37. Section IV: Specific Conditions and Stroke - p. g474 38. Chapter 35: Introduction - p. g474 39. Chapter 36: Cardiac Diseases - p. g474 40. Chapter 37: Atherosclerotic Disease of the Proximal Aorta - p. g487 41. Chapter 38: Stroke Related to Surgery and Other Procedures - p. g500 42. Chapter 39: Arterial Dissection, Fibromuscular Dysplasia, and Carotid Webs - p. g506 43. Chapter 40: Inflammatory and Infectious Vasculopathies - p. g527 44. Chapter 41: Reversible Cerebral Vasoconstriction Syndromes - p. g544 45. Chapter 42: Posterior Reversible Encephalopathy Syndrome - p. g552 46. Chapter 43: Stroke and Substance Abuse - p. g562 47. Chapter 44: Moyamoya Disease - p. g571 48. Chapter 45: Cerebral Autosomal Dominant Arteriopathy With Subcortical Infarcts and Leukoencephalopathy - p. g585 49. Chapter 46: Hematologic Disorders and Stroke - p. g590 50. Chapter 47: Migraine and Stroke - p. g603 51. Chapter 48: Cryptogenic Stroke - p. g613 52. Chapter 49: Cerebral Venous Thrombosis - p. g622 53. Section V: Diagnostic Studies - p. g636 54. Chapter 50: Introduction - p. g636 55. Chapter 51: Ultrasonography - p. g636 56. Chapter 52: Computed Tomography-Based Evaluation of Cerebrovascular Disease - p. g658 57. Chapter 53: Magnetic Resonance Imaging of Cerebrovascular Diseases - p. g674 58. Chapter 54: Cerebral Angiography - p. g695 59. Chapter 55: OMICs in Stroke: Insight Into Stroke Through Epigenomics, Transcriptomics, Proteomics, Lipidomics, and Metabolomics - p. g713 60. Section VI: Therapy - p. g721 61. Part A: Medical Therapy - p. g721 62. Chapter 56: Introduction - p. g721 63. Chapter 57: Stroke Systems of Care and Impact on Acute Stroke Treatment - p. g721 64. Chapter 58: Prehospital and Emergency Department Care of the Patient With Acute Stroke - p. g733 65. Chapter 59: Intravenous Thrombolysis - p. g748 66. Chapter 60: Antithrombotic Therapy for Treatment of Acute Ischemic Stroke - p. g771 67. Chapter 61: General Stroke Management and Stroke Units - p. g785 68. Chapter 62: Critical Care of the Patient With Acute Stroke - p. g799 69. Chapter 63: Pharmacologic Modification of Acute Cerebral Ischemia - p. g827 70. Chapter 64: Treatment of “Other” Stroke Etiologies - p. g848 71. Chapter 65: Medical Therapy of Intracerebral and Intraventricular Hemorrhage - p. g865 72. Chapter 66: Rehabilitation and Recovery of the Patient With Stroke - p. g877 73. Chapter 67: Interventions to Improve Recovery After Stroke - p. g887 74. Chapter 68: Enhancing Stroke Recovery With Cellular Therapies - p. g898 75. Chapter 69: Antiplatelet Therapy for Secondary Prevention of Stroke - p. g910 76. Chapter 70: Secondary Prevention of Cardioembolic Stroke - p. g930 77. Chapter 71: Design of Stroke-Related Clinical Trials - p. g942 78. Part B: Interventional Therapy - p. g954 79. Chapter 72: Introduction - p. g954 80. Chapter 73: Endovascular Therapy of Extracranial and Intracranial Occlusive Disease - p. g954 81. Chapter 74: Endovascular Treatment of Acute Ischemic Stroke - p. g969 82. Chapter 75: Endovascular Treatment of Intracranial Aneurysms - p. g983 83. Chapter 76: Interventional Therapy of Brain and Spinal Arteriovenous Malformations - p. g999 84. Chapter 77: Dural Arteriovenous Malformations - p. g1015 85. Part C: Surgical Therapy - p. g1026 86. Chapter 78: Introduction - p. g1026 87. Chapter 79: Surgery of Anterior and Posterior Aneurysms - p. g1026 88. Chapter 80: Surgery for Intracerebral Hemorrhage - p. g1046 89. Chapter 81: Management of Intraventricular Hemorrhage - p. g1053 90. Chapter 82: Surgical Management of Cranial and Spinal Arteriovenous Malformations - p. g1064 91. Chapter 83: Surgical Management of Cavernous Malformations and Venous Anomalies - p. g1076 92. Chapter 84: Indications for Carotid Endarterectomy in Patients With Asymptomatic and Symptomatic Carotid Stenosis - p. g1083 93. Chapter 85: Extracranial–Intracranial Bypass for Cerebral Ischemia - p. g1089 94. Chapter 86: Decompressive Craniectomy for Infarction and Intracranial Hemorrhages - p. g1098 95. Index - p. g1111
